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Epigenetic biomarker screening by FLIM-FRET for combination therapy in ER+ breast cancer

HATi Histone acetyltransferase inhibitor MBD2 Methyl-CpG-binding domain protein 2 TAM Tamoxifen Wenjie Liu and Yi Cui contributed equally to this work. Electronic supplementary material The online

Solubility-mediated sustained release enabling nitrate additive in carbonate electrolytes for stable lithium metal anode

Allen Pei Oliver Nix Yanbin Li Yi Cui The physiochemical properties of the solid-electrolyte interphase, primarily governed by electrolyte composition, have a profound impact on the electrochemical

Measuring the lactate-to-creatine ratio via 1H NMR spectroscopy can be used to noninvasively evaluate apoptosis in glioma cells after X-ray irradiation

BackgroundRadiotherapy is among the commonly applied treatment options for glioma, which is one of the most common types of primary brain tumor. To evaluate the effect of radiotherapy noninvasively, it is vital for oncologists to monitor the effects of X-ray irradiation on glioma cells. Preliminary research had showed that PKC-ι expression correlates with tumor cell apoptosis...

An electrochemical thermal transistor

The ability to actively regulate heat flow at the nanoscale could be a game changer for applications in thermal management and energy harvesting. Such a breakthrough could also enable the control of heat flow using thermal circuits, in a manner analogous to electronic circuits. Here we demonstrate switchable thermal transistors with an order of magnitude thermal on/off ratio...

Analysis of temperature field of grain and drying medium for grain drying integrated mechanical device.

In order to improve the working efficiency of the drying tower and the hot blast stove in the process of grain drying, this paper proposes a method to solve the problems of air pollution and energy waste caused by excessive combustion or insufficient combustion of the hot blast stove. Based on finite element analysis, this paper uses ANSYS software to simulate the drying process...

Attentional bias modification in reducing test anxiety vulnerability: a randomized controlled trial

A tendency to selectively process a threat to positive information may be involved in the etiology of anxiety disorders. The aim of this study is to examine whether attentional bias modification (ABM) can be used to modify high test-anxiety individuals’ attention to emotional information and whether this change is related to anxiety vulnerability. Seventy-seven undergraduates...

Study on optimization experiment and characteristic test of biomass granule forming machine

According to the biomass pellet fuel forming machine, problems such as high energy consumption, easy clogging, and low efficiency exist in the granulation process. In this paper, corn and wheat stalks are used as raw materials to study the effects of the size of the raw materials and the moisture content on the formation rate, particle average length, particle density, mechanical...

Basic studies on epigenetic carcinogenesis of low-dose exposure to 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) in vitro

1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) has been widely studied as a neurotoxic substance, however, only few reports have explored its effect on carcinogenicity. Since the aberrant modification of DNA methylation occurs very early in almost all human cancers, the focus of this study is to assess the carcinogenicity of TaClo by characterizing alterations of the...

Incorporating prior biological knowledge for network-based differential gene expression analysis using differentially weighted graphical LASSO

Background Conventional differential gene expression analysis by methods such as student’s t-test, SAM, and Empirical Bayes often searches for statistically significant genes without considering the interactions among them. Network-based approaches provide a natural way to study these interactions and to investigate the rewiring interactions in disease versus control groups. In...

Bilateral congenital venous tortuosity and dilatation combined with cilioretinal artery: a photographic essay

Bilateral congenital venous tortuosity and dilatation combined with cilioretinal artery: a photographic essay Nuo Xu,1 Yi Cui,2 Zhonghai Gao1 1Department of Ophthalmology, Fujian Provincial Hospital

Reactivation of dead sulfide species in lithium polysulfide flow battery for grid scale energy storage

• PubMed • Google Scholar Search for Yi Cui in:Nature Research journals • PubMed • Google Scholar Contributions Y.C. conceived the project. Y.J. and G.Z. assembled the batteries and performed the battery ... . wrote the manuscript. Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Yi Cui. Electronic supplementary material Supplementary Movie

Upregulation of miR-665 promotes apoptosis and colitis in inflammatory bowel disease by repressing the endoplasmic reticulum stress components XBP1 and ORMDL3

Manying Li Shenghong Zhang Yun Qiu Yao He Baili Chen Ren Mao Yi Cui Zhirong Zeng Minhu Chen MicroRNAs are critical post-transcriptional regulators of gene expression and key mediators of pathophysiology

A Prussian blue route to nitrogen-doped graphene aerogels as efficient electrocatalysts for oxygen reduction with enhanced active site accessibility

Developing high-performance nonprecious-metal electrocatalysts for the oxygen reduction reaction (ORR) is crucial for a variety of renewable energy conversion and storage systems. Toward that end, rational catalyst design principles that lead to highly active catalytic centers and enhanced active site accessibility are undoubtedly of paramount importance. Here, we used Prussian...

Dissecting the behavior and function of MBD3 in DNA methylation homeostasis by single-molecule spectroscopy and microscopy

The detailed mechanism for DNA methylation homeostasis relies on an intricate regulatory network with a possible contribution from methyl-CpG-binding domain protein 3 (MBD3). In this study we examine the single-molecule behavior of MBD3 and its functional implication in balancing the activity of DNA methyltransferases (DNMTs). Besides a localization tendency to DNA demethylating...

Avoiding short circuits from zinc metal dendrites in anode by backside-plating configuration

for Yi Cui in:Nature Research journals • PubMed • Google Scholar Contributions S.H. and Y.C. conceived and designed the experiments. S.H. performed the experiments. S.W.L. performed numerical ... . Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Yi Cui. Supplementary information PDF files1.Supplementary Information Supplementary

Molecular Identification of ten species of stored-product psocids through microarray method based on ITS2 rDNA

Stored-product psocids (Psocoptera: Liposcelididae) are cosmopolitan storage pests that can damage stored products and cause serious economic loss. However, because of the body size (~1 mm) of eggs, nymphs, and adults, morphological identification of most stored-product psocids is difficult and hampers effective identification. In this study, 10 economically important stored...

Warming up human body by nanoporous metallized polyethylene textile

manuscript. Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Yi Cui. Electronic supplementary material Supplementary InformationPeer Review ... journals • PubMed • Google Scholar Search for Chenyu Zhou in:Nature Research journals • PubMed • Google Scholar Search for Shanhui Fan in:Nature Research journals • PubMed • Google Scholar Search for Yi

Lithium-coated polymeric matrix as a minimum volume-change and dendrite-free lithium metal anode

• Google ScholarSearch for Yi Cui in:Nature Research journals • PubMed • Google Scholar Contributions Y.L., D.L. and Y.C. conceived the idea. Y.L. and D.L. carried out the materials synthesis and ... on the manuscript. Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Yi Cui. Supplementary information PDF files1.Supplementary