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Spatial, temporal, and spatiotemporal analysis of mumps in Guangxi Province, China, 2005–2016

The resurgence of mumps around the world occurs frequently in recent years. As the country with the largest number of cases in the world, the status of mumps epidemics in China is not yet clear. This study, taking the relatively serious epidemic province of Guangxi as the example, aimed to examine the spatiotemporal pattern and epidemiological characteristics of mumps, and...

Identifying genetic diversity of O antigens in Aeromonas hydrophila for molecular serotype detection

the strains. We thank Dr. Laiyou Wang for helpful suggestions. Author Contributions Funding acquisition: Bin Yang, Bin Liu. Data curation: Hengchun Cao, Chengqian Qian, Zhiqiu Yin, Lu Wang, Yi Wei

Metformin: a review of its potential indications

Metformin: a review of its potential indications Yi-Wei Wang,1,* Si-Jia He,1,* Xiao Feng,1 Jin Cheng,1 Yun-Tao Luo,1 Ling Tian,2 Qian Huang1 1The Comprehensive Cancer Center and Shanghai Key

NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway

Pattern recognition receptors (PRRs) are crucial for host defense and tissue homeostasis against infecting pathogens. PRRs are highly conserved cross species, suggesting their key roles in fundamental biological processes. Though much have been learned for NOD1 receptor in the innate and adaptive immune responses, the roles of NOD1 during embryonic and larval stages remain poorly...

The herbal decoction modified Danggui Buxue Tang attenuates immune-mediated bone marrow failure by regulating the differentiation of T lymphocytes in an immune-induced aplastic anemia mouse model

Conceptualization: Limin Chai. Data curation: Peiying Deng, Xue Li, Yi Wei. Formal analysis: Peiying Deng, Xue Li, Yi Wei, Juan Liu, Meng Chen. Funding acquisition: Limin Chai. Investigation: Lingqun Zhu, Limin

A Novel Inhibitor Against Mushroom Tyrosinase with a Double Action Mode and Its Application in Controlling the Browning of Potato

In order to search for a new method for the anti-browning of food products, a novel hydroxypyridinone (HPO) derivative with a formyl group was evaluated for its anti-tyrosinase property. This compound was found to exhibit potent tyrosinase inhibition on the monophenolase activity of mushroom tyrosinase with an IC50 value of 1.33 μM, indicating that this HPO derivative was 12-fold...

Cell sex affects extracellular matrix protein expression and proliferation of smooth muscle progenitor cells derived from human pluripotent stem cells

Background Smooth muscle progenitor cells (pSMCs) differentiated from human pluripotent stem cells (hPSCs) hold great promise for treating diseases or degenerative conditions involving smooth muscle pathologies. However, the therapeutic potential of pSMCs derived from men and women may be very different. Cell sex can exert a profound impact on the differentiation process of stem...

An Early Instance of Upper Palaeolithic Personal Ornamentation from China: The Freshwater Shell Bead from Shuidonggou 2

We report the discovery and present a detailed analysis of a freshwater bivalve from Shuidonggou Locality 2, layer CL3. This layer is located c. 40 cm below layer CL2, which has yielded numerous ostrich eggshell beads. The shell is identified as the valve of a Corbicula fluminea. Data on the occurrence of this species in the Shuidonggou region during Marine Isotope Stage 3 and...

Three-dimensional imaging of the nucleon and semi-inclusive high-energy reactions

We present a short overview of studies of the transverse-momentum-dependent parton distribution functions of the nucleon. The aim of such studies is to provide three-dimensional imaging of the nucleon and a comprehensive description of semi-inclusive high-energy reactions. By summarizing what we have done in constructing the theoretical framework for inclusive deep inelastic...

Low palaeoelevation of the northern Lhasa terrane during late Eocene: Fossil foraminifera and stable isotope evidence from the Gerze Basin

The Lhasa terrane is a key region for understanding the paleoelevation of the southern Tibetan Plateau after India-Asia collision. The Gerze Basin, located in the northern part of the Lhasa terrane, is a shortening-related basin. We discovered Lagena laevis (Bandy) fossils in upper Eocene strata of the Gerze Basin. This type of foraminifera is associated with lagoon and estuarine...

The Description of Shale Reservoir Pore Structure Based on Method of Moments Estimation

Shale has been considered as good gas reservoir due to its abundant interior nanoscale pores. Thus, the study of the pore structure of shale is of great significance for the evaluation and development of shale oil and gas. To date, the most widely used approaches for studying the shale pore structure include image analysis, radiation and fluid invasion methods. The detailed pore...

A Riccati-Bernoulli sub-ODE method for nonlinear partial differential equations and its application

The Riccati-Bernoulli sub-ODE method is firstly proposed to construct exact traveling wave solutions, solitary wave solutions, and peaked wave solutions for nonlinear partial differential equations. A Bäcklund transformation of the Riccati-Bernoulli equation is given. By using a traveling wave transformation and the Riccati-Bernoulli equation, nonlinear partial differential...

Exact solutions and multi-symplectic structure of the generalized KdV-type equation

The homogeneous balance of undetermined coefficients method is proposed to obtain not only exact solutions but also multi-symplectic structure of some nonlinear partial differential equations. Bilinear equation, N-soliton solutions, traveling wave solutions and multi-symplectic structure are obtained by applying the proposed method to the KdV equation. Accordingly, the definition...

MiR-124 inhibits the migration and invasion of human hepatocellular carcinoma cells by suppressing integrin αV expression

Tumor metastasis is the major cause of cancer-related death especially in human hepatocellular carcinoma (HCC). Although microRNAs have been implicated in tumor development, the roles of miR-124 in HCC metastasis are still not well understood. We conducted functional analysis in this study to investigate miR-124. We observed that miR-124 significantly retarded the wound healing...

Serum proteomic-based analysis identifying autoantibodies against PRDX2 and PRDX3 as potential diagnostic biomarkers in nasopharyngeal carcinoma

. Carbamidomethylation on Cys was specified as fixed modification. All MS/MS spectra were manually verified. ELISA for autoantibodies ELISA for autoantibodies against PRDX2 and PRDX3 was performed by two researchers (Yi ... -Wei Xu and LieHao Lin) as previously described [13, 18]. Briefly, purified recombinant antigens, PRDX2 (Sino Biological Inc.) and PRDX3 (Abcam, ab168006) were diluted to a final protein concentration of

Alcohol intake and associated risk of major cardiovascular outcomes in women compared with men: a systematic review and meta-analysis of prospective observational studies

Background The prevalence of alcohol intake is increasing among women in some populations. Alcohol consumption plays an important role in the risk of major cardiovascular outcomes and total mortality. Here, we conducted a meta-analysis to estimate the association between alcohol intake and major cardiovascular outcomes or total mortality in women compared with men. Methods We...

Eliciting cytotoxic T lymphocytes against human laryngeal cancer-derived antigens: evaluation of dendritic cells pulsed with a heat-treated tumor lysate and other antigen-loading strategies for dendritic-cell-based vaccination

Background Dendritic cells (DCs) have been used successfully in clinical pilot studies. However, tumor-specific immunity and clinical responses were only induced in certain cancer patients. It has been well documented that immunotherapy efficacy can be optimized for responses using antigen pulsing. Methods The human laryngeal squamous cell cancer (LSCC) cell line SNU899 was used...

Correlation between the Uptake of 18F-Fluorodeoxyglucose (18F-FDG) and the Expression of Proliferation-Associated Antigen Ki-67 in Cancer Patients: A Meta-Analysis

Objective To study the correlation between 18F-FDG uptake and cell proliferation in cancer patients by meta-analysis of published articles. Methods We searched PubMed (MEDLINE included), EMBASE, and Cochrane Database of Systematic Review, and selected research articles on the relationship between 18F-FDG uptake and Ki-67 expression (published between August 1, 1994-August 1, 2014...

Prognostic and clinical significance of claudin-4 in gastric cancer: a meta-analysis

Background The current reports on the association of claudin-4 expression with gastric cancer outcome were inconsistent. Thus, we conducted a meta-analysis to assess the association of claudin-4 expression with the prognosis and clinical parameters more precisely. Methods Systematic searches on PubMed, Embase, and Cochrane Library prior to December 2014 were performed. The pooled...