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Decoding topologically associating domains with ultra-low resolution Hi-C data by graph structural entropy

• Google Scholar Search for Jimin Han in:Nature Research journals • PubMed • Google Scholar Search for Yi Wei in:Nature Research journals • PubMed • Google Scholar Search for Yun Deng in:Nature Research

Glyburide and retinoic acid synergize to promote wound healing by anti-inflammation and RIP140 degradation

-Wei Lin, Pu-Ste Liu, Kasey Ah Pook & Li-Na Wei AuthorsSearch for Yi-Wei Lin in:Nature Research journals • PubMed • Google Scholar Search for Pu-Ste Liu in:Nature Research journals • PubMed • Google

Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways

at the Academia Sinica, Taiwan, for technical assistance. Conceptualization: Jueng-Tsueng Weng, Yi-Wei Tsuei, Tsu-Shing Wang, Yung-Hsi Kao. Formal analysis: Zi-Han Tian, Li-Jane Shih, An-Ci Siao, Tsai ... -Yun Chan. Funding acquisition: Yi-Wei Tsuei, Yow-Chii Kuo, Yung-Hsi Kao. Investigation: Zi-Han Tian, An-Ci Siao, Tsai-Yun Chan, Yung-Hsi Kao. Methodology: Zi-Han Tian. Project administration: Zi-Han

Characterization of the second- and third-harmonic optical susceptibilities of atomically thin tungsten diselenide

Research Foundation of Singapore (NRF-CRP Grant No. R-144-000-295-281). Author information Author notes Henrique G. Rosa and Yi Wei Ho contributed equally to this work. AffiliationsCentre for Advanced 2D ... Materials (CA2DM), National University of Singapore, 6 Science Drive 2, Singapore, 117546, SingaporeHenrique G. Rosa, Yi Wei Ho, Ivan Verzhbitskiy, Manuel J. F. L. Rodrigues, Goki Eda, Vitor M. Pereira & José

Interference alignment and power allocation for the MIMO X channels with multiple layers of relays

In this paper, we study a system consisting of a single source, a single destination, and multiple layers of parallel relays. The system is considered as a combination of broadcast channels, multiple input multiple output (MIMO) X channels, and multiple-access channels. Interference alignment (IA) is used throughout the whole system, and perfect channel state information (CSI) is...

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Neuroinflammation, which ultimately leads to neuronal loss, is considered to play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process is characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress is commonly associated with impairments in neuronal function and cognition, but its relationship and role in...

Single-component and fast-curing epoxy resin for liquid composite molding processes

Development of single-component and fast-curing epoxy resins is highly desired for many industry applications. In this work, we report an epoxy system based on diglycidyl ether of bisphenol A (DGEBA) and 1-(2-cyanoethyl)-2-ethyl-4- methylimidazole (1C2E4MIM). The inductive effect of electron-withdrawing cyano group distinctly increases the latency of 1C2E4MIM without sacrificing...

Single-component and fast-curing epoxy resin for liquid composite molding processes

Development of single-component and fast-curing epoxy resins is highly desired for many industry applications. In this work, we report an epoxy system based on diglycidyl ether of bisphenol A (DGEBA) and 1-(2-cyanoethyl)-2-ethyl-4- methylimidazole (1C2E4MIM). The inductive effect of electron-withdrawing cyano group distinctly increases the latency of 1C2E4MIM without sacrificing...

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Neuroinflammation, which ultimately leads to neuronal loss, is considered to play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process is characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress is commonly associated with impairments in neuronal function and cognition, but its relationship and role in...

In-depth study of DNA binding of Cys2His2 finger domains in testis zinc-finger protein

Previously, we identified that both fingers 1 and 2 in the three Cys2His2 zinc-finger domains (TZD) of testis zinc-finger protein specifically bind to its cognate DNA; however, finger 3 is non-sequence–specific. To gain insights into the interaction mechanism, here we further investigated the DNA-binding characteristics of TZD bound to non-specific DNAs and its finger segments...

Metformin: a review of its potential indications

Metformin: a review of its potential indications Yi-Wei Wang,1,* Si-Jia He,1,* Xiao Feng,1 Jin Cheng,1 Yun-Tao Luo,1 Ling Tian,2 Qian Huang1 1The Comprehensive Cancer Center and Shanghai Key

Laboratory Diagnosis of Central Nervous System Infection

Central nervous system (CNS) infections are potentially life threatening if not diagnosed and treated early. The initial clinical presentations of many CNS infections are non-specific, making a definitive etiologic diagnosis challenging. Nucleic acid in vitro amplification-based molecular methods are increasingly being applied for routine microbial detection. These methods are a...

MicroRNA-142-3p is involved in regulation of MGMT expression in glioblastoma cells

,4,5 Chun-Fu Lin,1,2 Pin-I Huang,2,6 Yi-Wei Chen,2,6 Hsin-I Ma,7 Ming-Teh Chen1,2 1Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 2Faculty of Medicine, National

The herbal decoction modified Danggui Buxue Tang attenuates immune-mediated bone marrow failure by regulating the differentiation of T lymphocytes in an immune-induced aplastic anemia mouse model

Conceptualization: Limin Chai. Data curation: Peiying Deng, Xue Li, Yi Wei. Formal analysis: Peiying Deng, Xue Li, Yi Wei, Juan Liu, Meng Chen. Funding acquisition: Limin Chai. Investigation: Lingqun Zhu, Limin

Hydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4

a grant from Academia Sinica and Ministry of Science and Technology, Taiwan (105-0210-0113-01). Data curation: Chinpan Chen, You-Di Liao. Formal analysis: Ting-Wei Chang, Shu-Yi Wei, Shih-Han Wang ... , Hung-Mu Wei, Yu-June Wang, Chiu-Feng Wang. Funding acquisition: Chinpan Chen, You-Di Liao. Investigation: Ting-Wei Chang, Shu-Yi Wei, Shih-Han Wang, Hung-Mu Wei, Yu-June Wang, Chiu-Feng Wang

A Novel Inhibitor Against Mushroom Tyrosinase with a Double Action Mode and Its Application in Controlling the Browning of Potato

In order to search for a new method for the anti-browning of food products, a novel hydroxypyridinone (HPO) derivative with a formyl group was evaluated for its anti-tyrosinase property. This compound was found to exhibit potent tyrosinase inhibition on the monophenolase activity of mushroom tyrosinase with an IC50 value of 1.33 μM, indicating that this HPO derivative was 12-fold...

Cell sex affects extracellular matrix protein expression and proliferation of smooth muscle progenitor cells derived from human pluripotent stem cells

Background Smooth muscle progenitor cells (pSMCs) differentiated from human pluripotent stem cells (hPSCs) hold great promise for treating diseases or degenerative conditions involving smooth muscle pathologies. However, the therapeutic potential of pSMCs derived from men and women may be very different. Cell sex can exert a profound impact on the differentiation process of stem...

Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy

Diffuse intrinsic pontine glioma is a very frustrating disease. Since the tumor infiltrates the brain stem, surgical removal is often impossible. For conventional radiotherapy, the dose constraint of the brain stem impedes attempts at further dose escalation. Boron neutron capture therapy (BNCT), a targeted radiotherapy, carries the potential to selectively irradiate tumors with...

An Early Instance of Upper Palaeolithic Personal Ornamentation from China: The Freshwater Shell Bead from Shuidonggou 2

We report the discovery and present a detailed analysis of a freshwater bivalve from Shuidonggou Locality 2, layer CL3. This layer is located c. 40 cm below layer CL2, which has yielded numerous ostrich eggshell beads. The shell is identified as the valve of a Corbicula fluminea. Data on the occurrence of this species in the Shuidonggou region during Marine Isotope Stage 3 and...