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Search: authors:"Yi Wei"

5 papers found.
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Nucleic acid assay system for tier II laboratories and moderately complex clinics to detect HIV in low-resource settings

There is a clear need for an instrument-free molecular diagnostic system for detecting human immunodeficiency virus type 1 (HIV-1) RNA or DNA that can be used in developing countries. Such a test could be used for early diagnosis of HIV-1 infection during infancy and could serve as a surrogate end point for vaccine trials. We developed the IsoAmp HIV-1 assay (BioHelix Corporation...

Characterization of Emergent HIV Resistance in Treatment-Naive Subjects Enrolled in a Vicriviroc Phase 2 Trial

Background. Vicriviroc is a C-C motif chemokine receptor 5 (CCR5) antagonist that is in clinical development for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. This study explored the molecular basis for the development of phenotypically resistant virus. Method. HIV-1 RNA from treatment-naive subjects who experienced virological failure in a phase 2...

Host Single-Nucleotide Polymorphisms and Altered Responses to Inactivated Influenza Vaccine

Yi-Wei Tang Haijing Li Huiyun Wu Yu Shyr Kathryn M. Edwards 0 0 Pediatrics, Vanderbilt University Medical Center , Nashville, Tennessee We analyzed the relationship between host gene polymorphisms

Dual Infections of the Central Nervous System with Epstein-Barr Virus

We describe clinical and laboratory characteristics of 16 patients with central nervous system (CNS) infection caused by Epstein-Barr virus (EBV) and another pathogen. Seven of 10 immunocompromised patients had coinfection with viruses (3 with cytomegalovirus, 2 with JC virus, and 2 with varicella zoster virus) and 3 with nonviral pathogens (2 with pneumococcus and 1 with...

Passive IgA Monoclonal Antibody Is No More Effective Than IgG at Protecting Mice from Mucosal Challenge with Respiratory Syncytial Virus

Respiratory syncytial virus (RSV) is a mucosally restricted pathogen that can cause severe respiratory disease. Although parenteral administration of sufficient RSV-specific IgG can reduce severity of lower respiratory tract infection in high-risk infants, delivery of antibody by direct airway administration is an attractive alternative. Topical and parenteral administration of...