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A Linkage between SmeIJK Efflux Pump, Cell Envelope Integrity, and σE-Mediated Envelope Stress Response in Stenotrophomonas maltophilia

Resistance nodulation division (RND) efflux pumps, such as the SmeIJK pump of Stenotrophomonas maltophilia, are known to contribute to the multidrug resistance in Gram-negative bacteria. However, some RND pumps are constitutively expressed even though no antimicrobial stresses occur, implying that there should be some physical implications for these RND pumps. In this study, the...

A Novel Inhibitor Against Mushroom Tyrosinase with a Double Action Mode and Its Application in Controlling the Browning of Potato

In order to search for a new method for the anti-browning of food products, a novel hydroxypyridinone (HPO) derivative with a formyl group was evaluated for its anti-tyrosinase property. This compound was found to exhibit potent tyrosinase inhibition on the monophenolase activity of mushroom tyrosinase with an IC50 value of 1.33 μM, indicating that this HPO derivative was 12-fold...

A Riccati-Bernoulli sub-ODE method for nonlinear partial differential equations and its application

The Riccati-Bernoulli sub-ODE method is firstly proposed to construct exact traveling wave solutions, solitary wave solutions, and peaked wave solutions for nonlinear partial differential equations. A Bäcklund transformation of the Riccati-Bernoulli equation is given. By using a traveling wave transformation and the Riccati-Bernoulli equation, nonlinear partial differential...

A Survey of the Practice and Perspectives of Chinese Acupuncturists on Deqi

 Jing Shi,7 Liang Chen,1 Yi-wei Liu,1 Ru-wen Zhang,1 Hui Zheng,1 De-hua Li,1 Xi Wu,1 and Fan-rong Liang1 1School of Acupuncture Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine

A Vaccine Targeted at CETP Alleviates High Fat and High Cholesterol Diet-Induced Atherosclerosis and Non-Alcoholic Steatohepatitis in Rabbit

Low HDL-C levels are associated with atherosclerosis and non-alcoholic steatohepatitis, and increased levels may reduce the risk of these diseases. Inhibition of cholesteryl ester transfer protein (CETP) activity is considered a promising strategy for increasing HDL-C levels. Since CETP is a self-antigen with low immunogenicity, we developed a novel CETP vaccine (Fc-CETP6) to...

A modified technique to improve the outcome of intubation with a left-sided double-lumen endobronchial tube

Background The use of a video-assisted laryngoscope (VL) has been shown to reduce the time to achieve intubation with a double-lumen endobronchial tube (DLT). As the blade of the VL is curved differently to a standard laryngoscope, the DLT must be angled into a hockey stick shape to fit properly. We conducted a study to establish which direction of angulation was best to...

Adverse stroke outcomes among patients with bipolar disorder

-Chang Shia, Herng-Ching Lin, Jiunn-Horng Kang. Methodology: Pao-Huan Chen, Yi-Wei Kao, Ben-Chang Shia, Herng-Ching Lin. Writing ? original draft: Pao-Huan Chen, Yi-Wei Kao, Ben-Chang Shia, Herng-Ching

Alcohol intake and associated risk of major cardiovascular outcomes in women compared with men: a systematic review and meta-analysis of prospective observational studies

Background The prevalence of alcohol intake is increasing among women in some populations. Alcohol consumption plays an important role in the risk of major cardiovascular outcomes and total mortality. Here, we conducted a meta-analysis to estimate the association between alcohol intake and major cardiovascular outcomes or total mortality in women compared with men. Methods We...

An Early Instance of Upper Palaeolithic Personal Ornamentation from China: The Freshwater Shell Bead from Shuidonggou 2

We report the discovery and present a detailed analysis of a freshwater bivalve from Shuidonggou Locality 2, layer CL3. This layer is located c. 40 cm below layer CL2, which has yielded numerous ostrich eggshell beads. The shell is identified as the valve of a Corbicula fluminea. Data on the occurrence of this species in the Shuidonggou region during Marine Isotope Stage 3 and...

An Inducible Fusaric Acid Tripartite Efflux Pump Contributes to the Fusaric Acid Resistance in Stenotrophomonas maltophilia

Background Fusaric acid (5-butylpicolinic acid), a mycotoxin, is noxious to some microorganisms. Stenotrophomonas maltophilia displays an intrinsic resistance to fusaric acid. This study aims to elucidate the mechanism responsible for the intrinsic fusaric acid resistance in S. maltophilia. Methodology A putative fusaric acid resistance-involved regulon fuaR-fuaABC was identified...

Analysis of Candidate-Host Immunogenetic Determinants in Herpes Simplex Virus-Associated Mollaret's Meningitis

Infection due to herpes simplex virus (HSV) is associated with recurrent aseptic meningitis (Mollaret's meningitis); however, the neuropathogenesis of this disease remains unknown. We collected 20 cerebrospinal fluid (CSF) specimens that were positive for HSV DNA by using polymerase chain reaction (PCR) assay from patients with a clinical diagnosis of Mollaret's meningitis...

Analysis of complete mitochondrial genome sequences increases phylogenetic resolution of bears (Ursidae), a mammalian family that experienced rapid speciation

Background Despite the small number of ursid species, bear phylogeny has long been a focus of study due to their conservation value, as all bear genera have been classified as endangered at either the species or subspecies level. The Ursidae family represents a typical example of rapid evolutionary radiation. Previous analyses with a single mitochondrial (mt) gene or a small...

Antibiotics in Laboratory Medicine, 5th Edition Edited by Victor Lorain Philadelphia: Lippincott Williams & Wilkins, 2005 832 pp., illustrated. $199.00 (cloth)

Yi-Wei Tang 0 0 Department of Medicine, Infectious Diseases Division, and Department of Pathology, Vanderbilt University Medical Center , Nashville, Tennessee Thorofare, NJ: Slack, 2004. 373 pp

Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways

at the Academia Sinica, Taiwan, for technical assistance. Conceptualization: Jueng-Tsueng Weng, Yi-Wei Tsuei, Tsu-Shing Wang, Yung-Hsi Kao. Formal analysis: Zi-Han Tian, Li-Jane Shih, An-Ci Siao, Tsai ... -Yun Chan. Funding acquisition: Yi-Wei Tsuei, Yow-Chii Kuo, Yung-Hsi Kao. Investigation: Zi-Han Tian, An-Ci Siao, Tsai-Yun Chan, Yung-Hsi Kao. Methodology: Zi-Han Tian. Project administration: Zi-Han

Association between the ERCC5 Asp1104His Polymorphism and Cancer Risk: A Meta-Analysis

Background Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light. Mutations in this gene cause a rare autosomal recessive syndrome, and its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity phenotype and cancer risk...

Association of LEP G2548A and LEPR Q223R Polymorphisms with Cancer Susceptibility: Evidence from a Meta-Analysis

BackgroundNumerous epidemiological studies have examined associations of genetic variations in LEP (G2548A, -2548 nucleotide upstream of the ATG start site) and LEPR (Q223R, nonsynonymous SNP in exon 6) with cancer susceptibility; however, the findings are inconsistent. Therefore, we performed a meta-analysis to comprehensively evaluate such associations. MethodsWe searched...

Asymmetric trapping of zwitterionic intermediates by sulphur ylides in a palladium-catalysed decarboxylation-cycloaddition sequence

Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, ChinaTian-Ren Li, Fen Tan, Liang-Qiu Lu, Yi Wei, Ya-Ni Wang, Yi-Yin Liu, Qing-Qing Yang, Jia-Rong Chen, De-Qing Shi & Wen-Jing ... Tan in:Nature Research journals • PubMed • Google ScholarSearch for Liang-Qiu Lu in:Nature Research journals • PubMed • Google ScholarSearch for Yi Wei in:Nature Research journals • PubMed • Google

Biodiesel Production Using Supercritical Methanol with Carbon Dioxide and Acetic Acid

Science and Technology, Neipu, Pingtung 91201, Taiwan Received 29 September 2012; Revised 11 December 2012; Accepted 17 December 2012 Academic Editor: Ahmed A. Mohamed Copyright © 2013 Chao-Yi Wei et