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10-Year experience regarding the reliability and morbidity of radio guided lymph node biopsy in penile cancer patients and the associated radiation exposure of medical staff in this procedure

Background The guidelines of the European Association of Urologists (EAU), of the German Society of Nuclear Medicine (DGN), and the European Society for Medical Oncology (ESMO) recommend sentinel lymph node biopsy (SLNB) for lymph node staging in penile cancer with non-palpable inguinal lymph nodes as one diagnostic method. Despite this, the method is neither widely nor regularly...

A Comparative Study of Techniques for Differential Expression Analysis on RNA-Seq Data

Recent advances in next-generation sequencing technology allow high-throughput cDNA sequencing (RNA-Seq) to be widely applied in transcriptomic studies, in particular for detecting differentially expressed genes between groups. Many software packages have been developed for the identification of differentially expressed genes (DEGs) between treatment groups based on RNA-Seq data...

A Computational Method Based on the Integration of Heterogeneous Networks for Predicting Disease-Gene Associations

The identification of disease-causing genes is a fundamental challenge in human health and of great importance in improving medical care, and provides a better understanding of gene functions. Recent computational approaches based on the interactions among human proteins and disease similarities have shown their power in tackling the issue. In this paper, a novel systematic and...

A Novel Finding of Sentinel Lymphatic Channels in Early Stage Breast Cancer Patients: Which May Influence Detection Rate and False-Negative Rate of Sentinel Lymph Node Biopsy

our novel findings. Conceived and designed the experiments: SW. Performed the experiments: MW WZ Yingchun Zhao. Analyzed the data: WZ MW. Contributed reagents/materials/analysis tools: TX XZ QD XL Yi ... Zhao LL LC. Wrote the paper: MW WZ. 1. Zavagno G , De Salvo GL , Scalco G , Bozza F , Barutta L , et al. ( 2008 ) A Randomized clinical trial on sentinel lymph node biopsy versus axillary lymph node

A chance-constrained stochastic approach to intermodal container routing problems

Zhao. Formal analysis: Yi Zhao. Funding acquisition: Xi Zhang. Investigation: Yi Zhao. Methodology: Yi Zhao, Ronghui Liu. Supervision: Ronghui Liu. Writing ± original draft: Yi Zhao. Writing ... information S1 Appendix. Parameter setting for the numerical example. (DOCX) Acknowledgments We thank Hongbo Ye (University of Leeds) for his technical support. Author Contributions Conceptualization: Yi

A general strategy for synthesis of metal oxide nanoparticles attached on carbon nanomaterials

We report a general strategy for synthesis of a large variety of metal oxide nanoparticles on different carbon nanomaterials (CNMs), including single-walled carbon nanotubes, multi-walled carbon nanotubes, and a few-layer graphene. The approach was based on the π-π interaction between CNMs and modified aromatic organic ligands, which acted as bridges connecting metal ions and...

A novel quinone-based polymer electrode for high performance lithium-ion batteries

Designing of high electrochemical performance organic electrode materials has attracted tremendous attention. Recent investigations revealed that quinone-based polymers along with the stable thioether bonds could achieve a high specific capacity and a good cycling stability simultaneously. In this study, we synthesized a novel ladder-structured polymer poly(2,3-dithiino-1,4...

A programmable metasurface with dynamic polarization, scattering and focusing control

Diverse electromagnetic (EM) responses of a programmable metasurface with a relatively large scale have been investigated, where multiple functionalities are obtained on the same surface. The unit cell in the metasurface is integrated with one PIN diode, and thus a binary coded phase is realized for a single polarization. Exploiting this anisotropic characteristic, reconfigurable...

A stewardship intervention program for safe medication management and use of antidiabetic drugs

A stewardship intervention program for safe medication management and use of antidiabetic drugs Rui-yi Zhao,1 Xiao-wen He,1 Yan-min Shan,1 Ling-ling Zhu,2 Quan Zhou3 1Clinical Nurse Specialist

Accelerated green process of tetramethylpyrazine production from glucose and diammonium phosphate

Background 2,3,5,6-Tetramethylpyrazine (TMP) is a popular food flavour additive. This biologically active ingredient has additional potential dietotherapy functions, such as in cardiovascular and cerebrovascular health. Previous production methods from renewable materials suffer from low yields and efficiency which seriously hampers the scaling up of the laboratory processes...

Alu-directed transcriptional regulation of some novel miRNAs

Background Despite many studies on the biogenesis, molecular structure and biological functions of microRNAs, little is known about the transcriptional regulatory mechanisms controlling the spatiotemporal expression pattern of human miRNA gene loci. Several lines of experimental results have indicated that both polymerase II (Pol-II) and polymerase III (Pol-III) may be involved...

An Agomir of miR-144-3p Accelerates Plaque Formation through Impairing Reverse Cholesterol Transport and Promoting Pro-Inflammatory Cytokine Production

Aims ATP-binding cassette transporter A1 (ABCA1) mediates the efflux of cholesterol and phospholipids to lipid-poor apolipoproteins, which then form nascent HDL, a key step in the mechanism of reverse cholesterol transport (RCT). While a series of microRNAs (miRNAs) have been identified as potent post-transcriptional regulators of lipid metabolism, their effects on ABCA1 function...

An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors

Transcription factors (TFs) play key roles in both development and stress responses. By integrating into and rewiring original systems, novel TFs contribute significantly to the evolution of transcriptional regulatory networks. Here, we report a high-confidence transcriptional regulatory map covering 388 TFs from 47 families in Arabidopsis. Systematic analysis of this map...

Analysis of a native whitefly transcriptome and its sequence divergence with two invasive whitefly species

Background Genomic divergence between invasive and native species may provide insight into the molecular basis underlying specific characteristics that drive the invasion and displacement of closely related species. In this study, we sequenced the transcriptome of an indigenous species, Asia II 3, of the Bemisia tabaci complex and compared its genetic divergence with the...

Antitumor activity of endogenous mFlt4 displayed on a T4 phage nanoparticle surface

-GPDS might be a novel anti-tumor metastatic agent in the future. Author contribution Shun-xiang REN and Feng YU designed research; Shun-xiang REN, Zhao-jun REN, Min-yi ZHAO, Shu-guang ZUO, and Feng ... • PubMed • Google ScholarSearch for Zhao-jun Ren in:Nature Research journals • PubMed • Google ScholarSearch for Min-yi Zhao in:Nature Research journals • PubMed • Google ScholarSearch for Xiao-bin Wang

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Compliance with ethics guidelines Xin-yan YU, Yi ZHAO, Xiao-xiao SONG, and Zhen-ya SONG declare that they have no conflict of

Association of Interleukin-23 receptor gene polymorphisms with susceptibility to Crohn’s disease: A meta-analysis

because of the analysis based on linkage considerations. Data extraction Data were collected by two independent investigators (Qi-Bing Xie and Yi Zhao). The characteristics of the selected articles were in ... Xu, Qi-Bing Xie, Yi Zhao & Yi Liu AuthorsSearch for Wang-Dong Xu in:Nature Research journals • PubMed • Google ScholarSearch for Qi-Bing Xie in:Nature Research journals • PubMed • Google ScholarSearch

Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. IL-32, a secreted protein, has been reported to be associated with several autoimmune diseases. Our preliminary experiment showed different plasma IL-32 levels than that mentioned in a published report on the same population. In order to elucidate the correlation between IL-32 and SLE, we determined the...

Association of vitamin D receptor gene polymorphisms with metabolic syndrome: a case–control design of population-based cross-sectional study in North China

management: YZ, YHZ; Data management: YZ, ZYH; Data analysis and drafting paper: SL, YZ. All authors read and approved the final manuscript. Authors information Yi Zhao and Sha Liao Co-first authors

Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population

donating blood samples. Author Contributions Conceptualization: Yi Zhao, Yuhong Zhang. Data curation: Yi Zhao. Formal analysis: Xiaoxia Li. Funding acquisition: Yuhong Zhang. Investigation: Xiaoxia Li ... , Yi Zhao, Yanan Jin, Tianjing Zhang, Xiaoyu Chang, Sha Liao, Hongxia Xu, Xiuying Liu, Jianjun Yang. 9 / 12 Project administration: Yuhong Zhang. Supervision: Yuhong Zhang. Writing ± original draft