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71 papers found.
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The relationship between optic nerve head deformation and visual field defects in myopic eyes with primary open-angle glaucoma

Conceptualization: Chih-Heng Hung, Yi-Chun Chen. Data curation: Chih-Heng Hung, Yi-Chun Chen. Formal analysis: Chih-Heng Hung, Yi-Chun Chen. Investigation: Chih-Heng Hung, Yi-Chun Chen. Methodology: Chih-Heng ... Hung, Yi-Chun Chen. Project administration: Chih-Heng Hung, Yi-Chun Chen. Resources: Chih-Heng Hung, Shwu-Huey Lee, Szu-Yuan Lin, Shun-Ling Lin, Yi-Chun Chen. Software: Chih-Heng Hung, Yi-Chun Chen

Pre-existing comorbidity modify emergency room visit for out-of-hospital cardiac arrest in association with ambient environments

agencies. Author Contributions Conceptualization: Yu-Chun Wang, Yi-Chun Chen, Chun-Yu Ko, Yue-Liang Leon Guo. Data curation: Yu-Chun Wang, Chun-Yu Ko. Writing ? original draft: Yu-Chun Wang. Writing

Food claims and nutrition facts of commercial infant foods

. Author Contributions Conceptualization: Yi Chun Chen. Data curation: Yu-Chin Koo. Formal analysis: Yu-Chin Koo, Jung-Su Chang. Funding acquisition: Yu-Chin Koo, Yi Chun Chen. Investigation: Yi Chun Chen ... . Methodology: Yu-Chin Koo, Yi Chun Chen. Project administration: Yi Chun Chen. Resources: Yu-Chin Koo, Yi Chun Chen. Software: Yu-Chin Koo, Yi Chun Chen. 11 / 13 Supervision: Yi Chun Chen. Validation: Yu

Characteristics and predictors for gastrointestinal hemorrhage among adult patients with dengue virus infection: Emphasizing the impact of existing comorbid disease(s)

. Funding acquisition: Ing-Kit Lee. Methodology: Wen-Chi Huang, Ing-Kit Lee. Project administration: Ing-Kit Lee. Resources: Ing-Kit Lee. Data curation: Wen-Chi Huang, Ing-Kit Lee, Yi-Chun Chen, Ching-Yen ... Tsai, Jien-Wei Liu. Investigation: Wen-Chi Huang, Ing-Kit Lee, Yi-Chun Chen, Ching-Yen Tsai, Jien-Wei Liu. 10 / 12 Supervision: Ing-Kit Lee. Validation: Wen-Chi Huang, Ing-Kit Lee, Yi-Chun Chen, Ching

Detection of mitochondrial DNA with 4977 bp deletion in leukocytes of patients with ischemic stroke

/ 11 Author Contributions Conceptualization: Yu-hua Huang, Yi-Chun Chen. Data curation: Chiung-Mei Chen, Kuo-Hsuan Chang, Huei-Wen Chen. Formal analysis: Yu-hua Huang, Huei-Wen Chen. Methodology ... : Chiung-Mei Chen, Yun-Shien Lee, Kuo-Hsuan Chang. Project administration: Yi-Chun Chen. Supervision: Yi-Chun Chen. Writing ± original draft: Yu-hua Huang. Writing ± review & editing: Yi-Chun Chen. 9

Comparison of the new Exponential Injury Severity Score with the Injury Severity Score and the New Injury Severity Score in trauma patients: A cross-sectional study

Conceptualization: Ching-Hua Hsieh. Formal analysis: Yi-Chun Chen. Project administration: Pao-Jen Kuo. Supervision: Ching-Hua Hsieh. Validation: Peng-Chen Chien. Writing ± original draft: Spencer C. H. Kuo

The Different Effects of Atorvastatin and Pravastatin on Cell Death and PARP Activity in Pancreatic NIT-1 Cells

Statins have been widely used drugs for lowering low-density lipoprotein and for preventing heart attack and stroke. However, the increased risk for developing diabetes during extended stain use and the molecular mechanisms remain unclear. The objective of this study was to elucidate the signaling pathway and biological function between necrosis and autophagy induced by...

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Rhodostomin (Rho) is a medium disintegrin containing a 48PRGDMP motif. We here showed that Rho proteins with P48A, M52W, and P53N mutations can selectively inhibit integrin αIIbβ3. To study the roles of the RGD loop and C-terminal region in disintegrins, we expressed Rho 48PRGDMP and 48ARGDWN mutants in Pichia pastoris containing 65P, 65PR, 65PRYH, 65PRNGLYG, and 65PRNPWNG C...

STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

Enriched PD-L1 expression in cancer stem-like cells (CSCs) contributes to CSC immune evasion. However, the mechanisms underlying PD-L1 enrichment in CSCs remain unclear. Here, we demonstrate that epithelial–mesenchymal transition (EMT) enriches PD-L1 in CSCs by the EMT/β-catenin/STT3/PD-L1 signaling axis, in which EMT transcriptionally induces N-glycosyltransferase STT3 through...

Risk of Flood-Related Diseases of Eyes, Skin and Gastrointestinal Tract in Taiwan: A Retrospective Cohort Study

Floods are known to cause serious environmental damage and health impacts. Studies on flood-related diseases have been primarily on individual events, and limited evidence could be drawn on potential health impacts from floods using large population data. This study used reimbursement records of one million people of the Taiwan National Health Insurance program to compare...

Post-traumatic acute kidney injury: a cross-sectional study of trauma patients

Background The causes of post-traumatic acute kidney injury (AKI) are multifactorial, and shock associated with major trauma has been proposed to result in inadequate renal perfusion and subsequent AKI in trauma patients. This study aimed to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized adult patients and its association with shock...

13-year nationwide cohort study of chronic kidney disease risk among treatment-naïve patients with chronic hepatitis B in Taiwan

Background Chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD) have high prevalences in Taiwan and worldwide. However, the association of untreated chronic hepatitis B virus (HBV) infection with chronic kidney disease (CKD) remains unclear. Methods This cohort study used claims data in the Taiwan National Health Insurance Research Database in 1996–2010, in...

Polymorphisms in the Promoters of the MMP-2 and TIMP-2 Genes Are Associated with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population

Background Spontaneous intracerebral hemorrhage (ICH) is a devastating stroke subtype. Matrix metalloproteinases (MMPs) function in the degradation of extracellular matrix and the activities of MMPs are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). This study aimed to discuss relationship of MMP-2 and TIMP-2 to spontaneous deep ICH...

Obese motorcycle riders have a different injury pattern and longer hospital length of stay than the normal-weight patients

Background The adverse effects of obesity on the physical health have been extensively studied in the general population, but not in motorcycle riders (includes both drivers and pillions). The aim of this study was to compare injury patterns, injury severities, mortality rates, and in-hospital or intensive care unit (ICU) length of stay (LOS) between obese and normal-weight...

Traumatic injuries among adult obese patients in southern Taiwan: a cross-sectional study based on a trauma registry system

Background The adverse impact of obesity has been extensively studied in the general population; however, the added risk of obesity on trauma-related mortality remains controversial. This study investigated and compared mortality as well injury patterns and length of stay (LOS) in obese and normal-weight patients hospitalized for trauma in the hospital and intensive care unit...

Development of a Simple Clinical Risk Score for Early Prediction of Severe Dengue in Adult Patients

We aimed to develop and validate a risk score to aid in the early identification of laboratory-confirmed dengue patients at high risk of severe dengue (SD) (i.e. severe plasma leakage with shock or respiratory distress, or severe bleeding or organ impairment). We retrospectively analyzed data of 1184 non-SD patients at hospital presentation and 69 SD patients before SD onset. We...

NP-59 SPECT/CT Imaging in Stage 1 Hypertensive and Atypical Primary Aldosteronism: A 5-Year Retrospective Analysis of Clinicolaboratory and Imaging Features

, Buddhist Tzu Chi Medical Foundation, Chiayi 622, Taiwan Received 18 August 2013; Accepted 18 September 2013 Academic Editors: P. Hartvig and O. Schillaci Copyright © 2013 Yi-Chun Chen et al. This is an

Use of the reverse shock index for identifying high-risk patients in a five-level triage system

Background The ratio of systolic blood pressure (SBP) to heart rate (HR), called the reverse shock index (RSI), is used to evaluate the hemodynamic stability of trauma patients. To minimize undertriage in emergency departments (EDs), we evaluated whether RSI < 1 (i.e., SBP lower than HR) could be used as an additional variable to identify patients at high risk for more severe...

Obese patients who fall have less injury severity but a longer hospital stay than normal-weight patients

Background The effects of obesity on injury severity and outcome have been studied in trauma patients but not in those who have experienced a fall. The aim of this study was to compare injury patterns, injury severities, mortality rates, and in-hospital or intensive care unit (ICU) length of stay (LOS) between obese and normal-weight patients following a fall. Methods Detailed...