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16 papers found.
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Reduced brain microstructural asymmetry in patients with childhood leukemia treated with chemotherapy compared with healthy controls

thank Keith A. Laycock, PhD, ELS, for editorial assistance. Author Contributions Conceptualization: Junyu Guo. Formal analysis: Junyu Guo, Yuanyuan Han, Yimei Li. Funding acquisition: Wilburn E ... . Reddick. Investigation: Junyu Guo. Methodology: Junyu Guo. Project administration: Junyu Guo. Supervision: Junyu Guo, Yimei Li, Wilburn E. Reddick. Visualization: Junyu Guo. Writing ? original draft

Hodgkin lymphoma patients have an increased incidence of idiopathic acquired aplastic anemia

Contributions Conceptualization: Taylor Linaburg, Daria V. Babushok. Data curation: Taylor Linaburg, Adam R. Davis, Yimei Li, Yuliya Borovskiy, Timothy S. Olson, Adam Bagg, Daria V. Babushok. Formal analysis ... : Taylor Linaburg, Stephen J. Schuster, Yimei Li, Timothy S. Olson, Adam Bagg, Daria V. Babushok. Funding acquisition: Taylor Linaburg, Elizabeth O. Hexner, Daria V. Babushok. Investigation: Taylor

Opioid utilization among pediatric patients treated for newly diagnosed acute myeloid leukemia

, Richard Aplenc. 12 / 15 Data curation: Kelly D. Getz, Yuan-Shung V. Huang. Formal analysis: Kelly D. Getz, Yimei Li. Funding acquisition: Richard Aplenc. Investigation: Kelly D. Getz, Tamara P. Miller ... , Yimei Li, Yuan Shung V. Huang, Brian T. Fisher, Richard Aplenc. 13 / 15 13. WHO Guidelines on the Pharmacological Treatment of Persisting Pain in Children with Medical Illnesses. WHO Guidelines Approved

Creation of a pediatric mature B-cell non-Hodgkin lymphoma cohort within the Pediatric Health Information System Database

Contributions Conceptualization: Rebecca Citrin, Kelly D. Getz, Richard Aplenc. Data curation: Yimei Li, Yuan-Shung Huang. Formal analysis: Rebecca Citrin, Yimei Li. Investigation: Joseph P. Horowitz ... . Methodology: Rebecca Citrin, Anne F. Reilly, Yimei Li, Kelly D. Getz, Alix E. Seif, Brian T. Fisher, Richard Aplenc. Resources: Richard Aplenc. Supervision: Anne F. Reilly, Yimei Li, Kelly D. Getz, Richard

Whole Chromosome 7 Gain Predicts Higher Risk of Recurrence in Pediatric Pilocytic Astrocytomas Independently From KIAA1549-BRAF Fusion Status

The most frequent genetic alteration identified in pediatric pilocytic astrocytomas and pilomyxoid variant is the KIAA1549-BRAF fusion, which typically results from a 2.0 Mb tandem duplication in chromosome band 7q34. Less frequent abnormalities include fusion genes, BRAF, FGFR, KRAS, and NF1 point mutations, and whole chromosome gains. To correlate genetic alterations with...

Bortezomib Inpatient Prescribing Practices in Free-Standing Children's Hospitals in the United States

This study is a pharmacoepidemiologic description of pediatric bortezomib use. Exposure was identified through billing codes in patients admitted to US children’s hospitals that participated with the Pediatric Health Information System between 2004 and 2013. Associated information on underlying diseases, demographics, institutional use, mortality, and physician type was collected...

Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma

Purpose To accurately map the retinal area covered by tumor in a prospectively enrolled cohort of children diagnosed with retinoblastoma. Methods Orbital MRI in 106 consecutive retinoblastoma patients (44 bilateral) was analyzed. For MRI-visible tumors, the polar angle and angle of eccentricity of points defining tumor perimeter on the retina were determined by triangulation from...

Assessing the fit of parametric cure models

Survival data can contain an unknown fraction of subjects who are “cured” in the sense of not being at risk of failure. We describe such data with cure-mixture models, which separately model cure status and the hazard of failure among non-cured subjects. No diagnostic currently exists for evaluating the fit of such models; the popular Schoenfeld residual (Schoenfeld, 1982...

Merging Children’s Oncology Group Data with an External Administrative Database Using Indirect Patient Identifiers: A Report from the Children’s Oncology Group

Purpose Clinical trials data from National Cancer Institute (NCI)-funded cooperative oncology group trials could be enhanced by merging with external data sources. Merging without direct patient identifiers would provide additional patient privacy protections. We sought to develop and validate a matching algorithm that uses only indirect patient identifiers. Methods We merged the...

Validation of a Pediatric Primary Care Network in a US Metropolitan Region as a Community-Based Infectious Disease Surveillance System

This cross-sectional study used Geographic Information System methods to compare sociodemographic and clinical characteristics of children enrolled and not enrolled in a primary care network to determine the suitability of the network to estimate population-based disease rates. We validated the network surveillance system by comparing invasive pneumococcal disease rates between...

Antifungal Prophylaxis Associated With Decreased Induction Mortality Rates and Resources Utilized in Children With New-Onset Acute Myeloid Leukemia

Background. Invasive fungal infections cause significant morbidity and mortality for children with acute myeloid leukemia (AML). Data on the comparative effectiveness of antifungal prophylaxis in this population are limited. Methods. A pediatric AML cohort was assembled from the Pediatric Health Information System database using ICD-9 codes and pharmacy data. Antifungal...

White matter integrity is associated with cognitive processing in patients treated for a posterior fossa brain tumor

Children treated for posterior fossa tumors experience reduced cognitive processing speed and, after imaging, show damage to white matter (WM) tracts in the brain. This study explores relationships between white matter microstructure, assessed by fractional anisotropy (FA), and speed of cognitive processing using tract-based spatial statistics (TBSS). At 36 months after treatment...


BACKGROUND: Ventriculoperitonal shunt placement has been identified as a risk factor for poor neurocognitive outcomes; yet the specific contribution of shunt placement on long-term outcomes has not been investigated in a large number of adult survivors of pediatric brain tumors. METHODS: Neurocognitive functions were evaluated in 130 adult survivors of pediatric brain tumors (50...