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Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet

To emphasize the mechanism of concurrent exercise effect on lipid disorders in insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD). Twenty male ApoE knockout mice were randomly divided into two groups: HFD group (n = 10) fed a high fat diet, and HFDE group (n = 10) with high-fat diet intervention for 12 weeks and swimming exercise. Other ten healthy male C57BL/6...

Epigenetic alterations to Polycomb targets precede malignant transition in a mouse model of breast cancer

Malignant breast cancer remains a major health threat to women of all ages worldwide and epigenetic variations on DNA methylation have been widely reported in cancers of different types. We profiled DNA methylation with ERRBS (Enhanced Reduced Representation Bisulfite Sequencing) across four main stages of tumor progression in the MMTV-PyMT mouse model (hyperplasia, adenoma...

Temperature-dependent cell death patterns induced by functionalized gold nanoparticle photothermal therapy in melanoma cells

Academy of Medical Sciences, Nanchang, ChinaYujuan Zhang, Xuelin Zhan, Shanshan Peng, Wei Huang, Ying Cai, Yanling Liu, Rong Li, Keng Yuan, Nanjin Zhou & Weiping MinJiangxi Provincial Key Laboratory of ... Immunotherapy, Nanchang, ChinaYujuan Zhang, Xuelin Zhan, Shanshan Peng, Wei Huang, Ying Cai, Yanling Liu, Keng Yuan, Nanjin Zhou & Weiping MinDepartment of Preventive Medicine, School of Medicine, Shenzhen

Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition

To date, the molecular mechanism underlying constitutive signal transducer and activator of transcription 3 (STAT3) activation in gliomas is largely unclear. In this study, we report that Smad6 is overexpressed in nuclei of glioma cells, which correlates with poor patient survival and regulates STAT3 activity via negatively regulating the Protein Inhibitors of Activated STAT3...

Classification and characterization of class III malocclusion in Chinese individuals

Background Class III malocclusion is a maxillofacial disorder that is characterised by a concave profile and can be attributed to both genetic inheritance and environmental factors. It is a clinical challenge due to our limited understanding of its aetiology. Revealing its prototypical diversity will contribute to our sequential exploration of the underlying aetiological...

Comprehensive genetic testing for female and male infertility using next-generation sequencing

PurposeTo develop a comprehensive genetic test for female and male infertility in support of medical decisions during assisted reproductive technology (ART) protocols.MethodsWe developed a next-generation sequencing (NGS) gene panel consisting of 87 genes including promoters, 5′ and 3′ untranslated regions, exons, and selected introns. In addition, sex chromosome aneuploidies and...

PIK3CA expression in diffuse large B cell lymphoma tissue and the effect of its knockdown in vitro

PIK3CA expression in diffuse large B cell lymphoma tissue and the effect of its knockdown in vitro Wenli Cui,1–4,* Shutao Zheng,5,6,* Zebing Liu,1–3 Weige Wang,1–3 Ying Cai,1–3 Rui Bi,1–3 Bing Cao,1 ... lymphoma; PIK3CA; proliferation; prognosis - open access to scientific and medical research O r i g i n a l r e s e a r c h Wenli cui 1–4,* shutao Zheng 5,6,* Zebing liu 1–3 Weige Wang1–3 Ying cai 1–3

Compensatory variances of drug-induced hepatitis B virus YMDD mutations

Although the drug-induced mutations of HBV have been ever documented, the evolutionary mechanism is still obscure. To deeply reveal molecular characters of HBV evolution under the special condition, here we made a comprehensive investigation of the molecular variation of the 3432 wild-type sequences and 439 YMDD variants from HBV genotype A, B, C and D, and evaluated the co...

A Practical Control Strategy for the Maglev Self-Excited Resonance Suppression

This paper addresses the control strategy for the suppression of maglev vehicle-bridge interaction resonance, which worsens the ride comfort of vehicle and degrades the safety of the bridge. Firstly, a minimum model containing a flexible bridge and ten levitation units is presented. Based on the minimum model, we pointed out that magnetic flux feedback instead of the traditional...

A Practical Control Strategy for the Maglev Self-Excited Resonance Suppression

This paper addresses the control strategy for the suppression of maglev vehicle-bridge interaction resonance, which worsens the ride comfort of vehicle and degrades the safety of the bridge. Firstly, a minimum model containing a flexible bridge and ten levitation units is presented. Based on the minimum model, we pointed out that magnetic flux feedback instead of the traditional...

Robust Head Pose Estimation Using a 3D Morphable Model

Received 30 September 2014; Accepted 17 November 2014 Academic Editor: Hui Zhang Copyright © 2015 Ying Cai et al. This is an open access article distributed under the Creative Commons Attribution License

MicroRNA expression and gene regulation drive breast cancer progression and metastasis in PyMT mice

Background MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression of their target genes. Numerous studies have shown that miRNAs are not only key regulators in important cellular processes but are also drivers in the development of many diseases, especially cancer. Estrogen receptor positive luminal B is the second...

Sample storage-induced changes in the quantity and quality of soil labile organic carbon

, Edmonton, AB T6G 2E3, CanadaShou-Qin Sun, Hui-Ying Cai & Scott X. ChangCanadian Forest Service, Northern Forestry Centre, 5320 122nd St. Edmonton, AB, T6H 3S5 CanadaJagtar S. Bhatti AuthorsSearch for Shou ... -Qin Sun in:Nature Research journals • PubMed • Google ScholarSearch for Hui-Ying Cai in:Nature Research journals • PubMed • Google ScholarSearch for Scott X. Chang in:Nature Research journals • PubMed

Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway

The protein ARHGDIA has been found to play distinct roles in cancer progression for several tumors. However, it remains elusive whether and how ARHGDIA plays functions in human glioma. In this study, we discovered that ARHGDIA is much downregulated in human glioma; meanwhile, its expression negatively correlates with glioma malignancy and positively relates to prognosis of glioma...

Lip closing force of Class III patients with mandibular prognathism: a case control study

Introduction To compare the lip closing force of patients with mandibular prognathism to that of patients without dentofacial anomalies. Methods The subject group included 62 female patients of Class III relationship with mandibular prognathism. The control group been comprised of 71 patients of Class I relationships without skeletal deformities. Maximum lip closing force and...

Effects of the Yeast RNA-Binding Protein Whi3 on the Half-Life and Abundance of CLN3 mRNA and Other Targets

Whi3 is an RNA binding protein known to bind the mRNA of the yeast G1 cyclin gene CLN3. It inhibits CLN3 function, but the mechanism of this inhibition is unclear; in previous studies, Whi3 made no observable difference to CLN3 mRNA levels, translation, or protein abundance. Here, we re-approach this issue using microarrays, RNA-Seq, ribosome profiling, and other methods. By...

Neuroprotective effect of heme oxygenase-2 knockout in the blood injection model of intracerebral hemorrhage

Background The toxicity of heme breakdown products may contribute to the pathogenesis of intracerebral hemorrhage (ICH). Heme catabolism is catalyzed by the heme oxygenase enzymes. We have previously reported that heme oxygenase-2 (HO-2), the constitutive isoform, protects neurons from hemin in vitro and reduces oxidative stress after striatal blood injection. In order to further...

The significance of NTR1 expression and its correlation with β-catenin and EGFR in gastric cancer

Background Several reports indicate the high-affinity receptor of NT (neurotensin), NTR1 (neurotensin receptor 1), in numerous detrimental functions linked to neoplastic progression of several cancer types. Recently, it has also been shown that NTR1 gene is a target of the Wnt/APC oncogenic pathways connected with the β-catenin/Tcf transcriptional complex and NT can stimulate...

The significance of NTR1 expression and its correlation with β-catenin and EGFR in gastric cancer

Several reports indicate the high-affinity receptor of NT (neurotensin), NTR1 (neurotensin receptor 1), in numerous detrimental functions linked to neoplastic progression of several cancer types. Recently, it has also been shown that NTR1 gene is a target of the Wnt/APC oncogenic pathways connected with the β-catenin/Tcf transcriptional complex and NT can stimulate cancer...