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Integrating environmental parameters and economic benefits to analyze the ecological agriculture (EA) application in the mountain rice paddy system of Chongqing, China

BackgroundAgrochemicals, such as pesticides and fertilizers used in the current conventional agriculture (CA), have contaminating effects on environments as well as food, which pose significant risks to non-target organisms and even human health. Under these environmental pressures, ecological agriculture (EA), using organic fertilizer for crop growth, was developed without...

Structure and evolution of double minutes in diagnosis and relapse brain tumors

Double minute chromosomes are extrachromosomal circular DNA fragments frequently found in brain tumors. To understand their evolution, we characterized the double minutes in paired diagnosis and relapse tumors from a pediatric high-grade glioma and four adult glioblastoma patients. We determined the full structures of the major double minutes using a novel approach combining...

DNA hypermethylated status and gene expression of PAX1/SOX1 in patients with colorectal carcinoma

DNA hypermethylated status and gene expression of PAX1/SOX1 in patients with colorectal carcinoma Jin Huang,1,2 Zhi-Rong Tan,1,2 Jing Yu,1,2 He Li,1,2 Qiao-Li Lv,1,2 Ying-Ying Shao,3 Hong-Hao Zhou1,2

Impact of augmented reality lessons on students’ STEM interest

In this paper, we explore the possibility of embedding augmented reality (AR) in authentic inquiry activities to contextualize students’ exploration of medical surgery, and investigate students’ perceptions of the AR lessons and simulators, and their Science, Technology, Engineering, and Mathematics (STEM) interest. Thirty-two senior high school students participated in the two...

Genome-Guided Phylo-Transcriptomic Methods and the Nuclear Phylogenetic Tree of the Paniceae Grasses

The past few years have witnessed a paradigm shift in molecular systematics from phylogenetic methods (using one or a few genes) to those that can be described as phylogenomics (phylogenetic inference with entire genomes). One approach that has recently emerged is phylo-transcriptomics (transcriptome-based phylogenetic inference). As in any phylogenetics experiment, accurate...

Levels of Serum 25(OH)VD3, HIF-1α, VEGF, vWf, and IGF-1 and Their Correlation in Type 2 Diabetes Patients with Different Urine Albumin Creatinine Ratio

Editor: Giovanni Annuzzi Copyright © 2016 Ying Shao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

Levels of Serum 25(OH)VD3, HIF-1α, VEGF, vWf, and IGF-1 and Their Correlation in Type 2 Diabetes Patients with Different Urine Albumin Creatinine Ratio

Editor: Giovanni Annuzzi Copyright © 2016 Ying Shao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

The draft genome of the C 3 panicoid grass species Dichanthelium oligosanthes

Background Comparisons between C 3 and C 4 grasses often utilize C 3 species from the subfamilies Ehrhartoideae or Pooideae and C 4 species from the subfamily Panicoideae, two clades that diverged over 50 million years ago. The divergence of the C 3 panicoid grass Dichanthelium oligosanthes from the independent C 4 lineages represented by Setaria viridis and Sorghum bicolor...

A Case of Special Complication following a Large Amount of Polyacrylamide Hydrogel Injected into the Epicranial Aponeurosis: Leukocytopenia

interests. Authors’ Contribution Li Rong, Ying Shao, and Duo Zhang took part in the operation. Duo Zhang finalized the paper and figures. Zhe Chen was the resident in charge of the medical record and follow

A Case of Special Complication following a Large Amount of Polyacrylamide Hydrogel Injected into the Epicranial Aponeurosis: Leukocytopenia

interests. Authors’ Contribution Li Rong, Ying Shao, and Duo Zhang took part in the operation. Duo Zhang finalized the paper and figures. Zhe Chen was the resident in charge of the medical record and follow

Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction

Naringin, a flavanone glycoside extracted from Citrus grandis Osbeck, has a wide range of pharmacological effects. In the present study we aimed at demonstrating the protective effect of naringin against diabetic kidney disease (DKD) and elucidating its possible molecular mechanism underlying. The beneficial effect of naringin was assessed in rats with streptozotocin (STZ...

A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Nuclear receptors (NRs) can regulate gene expression; therefore, they are classified as transcription factors. Despite the extensive research carried out on NRs, still several issues including (1) the expression profile of NRs in human tissues, (2) how the NR expression is modulated during atherosclerosis and metabolic diseases, and (3) the overview of the role of NRs in...

Altered Immune Profiles of Natural Killer Cells in Chronic Hepatitis B Patients: A Systematic Review and Meta-Analysis

Background Natural killer (NK) cells are the main effective component of the innate immune system that responds to chronic hepatitis B (CHB) infection. Although numerous studies have reported the immune profiles of NK cells in CHB patients, they are limited by inconsistent results. Thus, we performed a meta-analysis to characterize reliably the immune profiles of NK cells after...

Abnormal Localization and Tumor Suppressor Function of Epithelial Tissue-Specific Transcription Factor ESE3 in Esophageal Squamous Cell Carcinoma

Esophageal cancer is one of the most common malignant cancers worldwide. The molecular mechanism of esophageal squamous cell carcinoma (ESCC) is still poorly understood. ESE3 is a member of the Ets transcription family, which is only expressed in epithelial tissues and acts as a tumor suppressor gene in prostate cancer. Our study aim was to confirm whether ESE3 is involved in the...

Pathological conditions re-shape physiological Tregs into pathological Tregs

CD4+FOXP3+ regulatory T cells (Tregs) are a subset of CD4 T cells that play an essential role in maintaining peripheral immune tolerance, controlling acute and chronic inflammation, allergy, autoimmune diseases, and anti-cancer immune responses. Over the past 20 years, a significant progress has been made since Tregs were first characterized in 1995. Many concepts and principles...

Pathological conditions re-shape physiological Tregs into pathological Tregs

diseases, and cancers. Notes William Y Yang and Ying Shao contributed equally to this work. Declarations Acknowledgements This work is partially supported by NIH grants to Drs. XF. Yang and H. Wang