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Estimations and changes of the dominant discharge in Three Gorges Reservoir channel

Dominant discharge is an important parameter reflecting the water inflow process and river channel shape. Since the impoundment and implementation of the Three Gorges Reservoir (TGR), the bed-forming effect of the river channel in the reservoir area has changed significantly. Based on the observed water and sediment data from four hydrological stations in the upper Yangtze River...

Tigecycline as a dual inhibitor of retinoblastoma and angiogenesis via inducing mitochondrial dysfunctions and oxidative damage

(220100455) and Nature Science Foundation of Hubei Province (2011CDB526). Author information Author notes Ying Xiong and Wei Liu contributed equally to this work. AffiliationsWuhan University, Zhongnan ... , Department of Pharmacy, 430071, Wuhan, ChinaWei Liu AuthorsSearch for Ying Xiong in:Nature Research journals • PubMed • Google Scholar Search for Wei Liu in:Nature Research journals • PubMed • Google Scholar

Decoding topologically associating domains with ultra-low resolution Hi-C data by graph structural entropy

journals • PubMed • Google Scholar Search for Ying Xiong in:Nature Research journals • PubMed • Google Scholar Search for Zhihua Zhang in:Nature Research journals • PubMed • Google Scholar Contributions

Safety of Low-calcium Dialysate and its Effects on Coronary Artery Calcification in Patients Undergoing Maintenance Hemodialysis

Wen, Hua Gan, Zhengrong Li, Ying Xiong & Yunfeng XiaThe first hospital affiliated to Army Medical University, Department of Hepatology, Chongqing, 400038, ChinaXimin Sun AuthorsSearch for Yang Wen ... Search for Ximin Sun in:Nature Research journals • PubMed • Google Scholar Search for Ying Xiong in:Nature Research journals • PubMed • Google Scholar Search for Yunfeng Xia in:Nature Research journals

Angiopoietin-like protein 3 blocks nuclear import of FAK and contributes to sorafenib response

. AffiliationsDepartment of Urology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, ChinaYi Bao, Bing Liu, Tangliang Zhao, Ying Xiong & Linhui WangDepartment of Medical Genetics, Second Military ... for Zhipeng Xu in:Nature Research journals • PubMed • Google Scholar Search for Ying Xiong in:Nature Research journals • PubMed • Google Scholar Search for Shuhan Sun in:Nature Research journals

Location Model for Distribution Centers for Fulfilling Electronic Orders of Fresh Foods under Uncertain Demand

Business University, Beijing 100048, China 2Beijing Wuzi University, Beijing 101149, China Correspondence should be addressed to Ying Xiong; moc.361@853yxjtyk Received 10 July 2017; Accepted 14 September

Location Model for Distribution Centers for Fulfilling Electronic Orders of Fresh Foods under Uncertain Demand

Business University, Beijing 100048, China 2Beijing Wuzi University, Beijing 101149, China Correspondence should be addressed to Ying Xiong; moc.361@853yxjtyk Received 10 July 2017; Accepted 14 September

A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of diseases, including simple steatosis, nonalcoholic steatohepatitis (NASH), liver cirrhosis and hepatocellular carcinoma. Lipotoxicity, insulin resistance (IR) and inflammation are involved in the disease process. Lipotoxicity promotes inflammation and IR, which in turn, increase adipocyte lipolysis and exacerbates...

Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4–miR-18a pathway in cervical cancer

PD-L1, a key inhibitory immune receptor, has crucial functions in cancer immune evasion, but whether PD-L1 promotes the malignant properties of cervical cancer (CC) cells and the mechanism by which PD-L1 is regulated in CC remains unclear. We report that PD-L1 is overexpressed in CC, and shRNA-mediated PD-L1 depletion suppresses the proliferation, invasion, and tumorigenesis of...

Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation

Although previous studies have shown promise for targeting Musashi RNA-binding protein 2 (MSI-2) in diverse tumors, the role and mechanism of MSI-2 for cervical cancer (CC) progression and the regulation of MSI-2 expression remains unclear. Using gene expression and bioinformatic analysis, together with gain- and loss-of-function assays, we identified MSI-2 as a novel oncogenic...

An Optimal Schedule for Urban Road Network Repair Based on the Greedy Algorithm

The schedule of urban road network recovery caused by rainstorms, snow, and other bad weather conditions, traffic incidents, and other daily events is essential. However, limited studies have been conducted to investigate this problem. We fill this research gap by proposing an optimal schedule for urban road network repair with limited repair resources based on the greedy...

Hematopoietic Stem Cells as a Novel Source of Dental Tissue Cells

While earlier studies have suggested that cells positive for hematopoietic markers can be found in dental tissues, it has yet to be confirmed. To conclusively demonstrate this, we utilized a unique transgenic model in which all hematopoietic cells are green fluorescent protein+ (GFP+). Pulp, periodontal ligament (PDL) and alveolar bone (AvB) cell culture analysis demonstrated...

The analysis of corneal asphericity (Q value) and its related factors of 1,683 Chinese eyes older than 30 years

Purpose To determine corneal Q value and its related factors in Chinese subjects older than 30 years. Design Cross sectional study. Methods 1,683 participants (1,683 eyes) from the Handan Eye Study were involved, including 955 female and 728 male with average age of 53.64 years old (range from 30 to 107 years). The corneal Q values of anterior and posterior surfaces were measured...

Bidirectional Shifting Effects of the Sound Intensity on the Best Frequency in the Rat Auditory Cortex

Frequency and intensity are two independent attributes of sound stimuli. Psychoacoustic studies have found that the sound intensity can affect the perception of frequency; however, the underlying neuronal mechanism remains largely unknown. To investigate if and how the sound level affects the frequency coding for auditory cortical neurons, we recorded the activities of neuronal...

Multiscale studies on the nonlinear vibration of delaminated composite laminates–global vibration mode with micro buckles on the interfaces

Shuhua Chen Ying Xiong Zuyuan Tan Renhuai Liu Hong Yuan OPEN This paper presents a multiscale approach to study the nonlinear vibration of fiber reinforced composite laminates containing an embedded

Geochemical Characteristics and Geological Significance of the Tawangshan gold deposit in Dongfang City, Hainan Province

The Tawangshan gold deposit is located in the southwest of the Gezhen ductile shear zone in southwestern Hainan Island. Major, trace and rare earth element characteristics of the least altered granites and altered granite ores, as well as the oxygen and hydrogen isotopic features of the quartz, the sulfur and lead isotopic features of the pyrites, galena from this deposit were...

Low CCL17 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma

Background Chemokine (C–C motif) ligand 17 (CCL17) is a chemokine mainly produced by myeloid dendritic cells. It is a ligand for CC chemokine receptor 4 (CCR4) and CC chemokine receptor 8 (CCR8). The aim of this study was to investigate prognostic values of CCL17 expression in patients with clear cell renal cell carcinoma (ccRCC). Methods The study included 286 patients with...

An association of cognitive impairment with diabetes and retinopathy in end stage renal disease patients under peritoneal dialysis

Conceptualization: Jin-Lan Liao, Zu-Ying Xiong, Jie Dong. Data curation: Jin-Lan Liao, Zu-Ying Xiong, Zhi-Kai Yang, Li Hao, Gui-Ling Liu, Ye-Ping Ren, Qin Wang, Li-Ping Duan, Zhao-Xia Zheng, Jie Dong. Formal ... analysis: Jin-Lan Liao. Investigation: Jin-Lan Liao, Zu-Ying Xiong, Zhi-Kai Yang, Li Hao, Gui-Ling Liu, Ye-Ping Ren, Qin Wang, Li-Ping Duan, Zhao-Xia Zheng, Jie Dong. Methodology: Jin-Lan Liao, Zu-Ying