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The effects of storage temperature and duration of blood samples on DNA and RNA qualities

Medical Research, Kaohsiung Chang Gung Memorial Hospital for technical support. Author Contributions Conceptualization: Lien-Hung Huang, Liang-Jen Wang, Ying-Hsien Huang, Ho-Chang Kuo. Formal analysis ... : Sung-Chou Li. Investigation: Lien-Hung Huang, Pei-Hsien Lin, Kuo-Wang Tsai, Sung-Chou Li. Methodology: Pei-Hsien Lin, Kuo-Wang Tsai, Sung-Chou Li. Resources: Liang-Jen Wang, Ying-Hsien Huang

Anti-inflammatory effect of resveratrol in human coronary arterial endothelial cells via induction of autophagy: implication for the treatment of Kawasaki disease

Background Kawasaki disease (KD) is an acute febrile vasculitis in childhood, which is the leading cause of acquired heart disease in children. If untreated, KD can result in coronary aneurysms in 25% of patients, and even under intravenous immunoglobulin (IVIG) treatment, 10–20% of children will have IVIG resistance and increased risk of developing coronary arteritis...

Plasma Prostaglandin E2 Levels Correlated with the Prevention of Intravenous Immunoglobulin Resistance and Coronary Artery Lesions Formation via CD40L in Kawasaki Disease

Background A form of systemic vasculitis, Kawasaki disease (KD) occurs most frequently in children under the age of five years old. Previous studies have found that Prostaglandin E2 (PGE2) correlates with KD, although the related mechanisms are still unknown. CD40L may also be a marker of vasculitis in KD, so this study focuses on PGE2 and CD40L expression in KD. Materials and...

High-Dose Aspirin Is Associated with Anemia and Does Not Confer Benefit to Disease Outcomes in Kawasaki Disease

Background Kawasaki disease (KD) is also known as multiple mucocutaneous lymph node syndrome of systemic vasculitis and is a leading cause of coronary artery lesions (CAL) in childhood. Intravenous immunoglobulin (IVIG) has been proven to effectively reduce the incidence of CAL, but the role and effect dose of aspirin in KD is still unclear. Moreover, overt bleeding and anemia...

Major methylation alterations on the CpG markers of inflammatory immune associated genes after IVIG treatment in Kawasaki disease

Background Kawasaki disease (KD) is an autoimmune disease preferentially attacking children younger than five years worldwide. So far, the principal treatment to KD is the administration of Intravenous immunoglobulin (IVIG). Although DNA methylation plays important regulation roles in diseases, few studies investigated the regulation roles of DNA methylation in KD. Methods In...

Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4

Background Recent studies have shown that microRNA-29 (miR-29) is significantly decreased in liver fibrosis and that its downregulation influences the activation of hepatic stellate cells (HSCs). In addition, inhibition of the activity of histone deacetylases 4 (HDAC4) has been shown to strongly reduce HSC activation in the context of liver fibrosis. Objectives In this study, we...

Genome-Wide Association Study Identifies Novel Susceptibility Genes Associated with Coronary Artery Aneurysm Formation in Kawasaki Disease

Kawasaki disease (KD) or Kawasaki syndrome is known as a vasculitis of small to medium-sized vessels, and coronary arteries are predominantly involved in childhood. Generally, 20–25% of untreated with IVIG and 3–5% of treated KD patients have been developed coronary artery lesions (CALs), such as dilatation and aneurysm. Understanding how coronary artery aneurysms (CAAs) are...

Multisource feedback analysis of pediatric outpatient teaching

Background This study aims to evaluate the outpatient communication skills of medical students via multisource feedback, which may be useful to map future directions in improving physician-patient communication. Methods Family respondents of patients, a nurse, a clinical teacher, and a research assistant evaluated video-recorded medical students’ interactions with outpatients by...

Single-Nucleotide Polymorphism rs7251246 in ITPKC Is Associated with Susceptibility and Coronary Artery Lesions in Kawasaki Disease

Kawasaki disease (KD) is a multi-systemic vasculitis that preferentially affects children. A single nucleotide polymorphism (SNP) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) has been identified to be an important polymorphism in the risk of KD. This study was conducted to comprehensively investigate the associations between all tagging SNPs of ITPKC in the risk of KD in a...

Genetic Variants of CD209 Associated with Kawasaki Disease Susceptibility

Background Kawasaki disease (KD) is a systemic vasculitis with unknown etiology mainly affecting children in Asian countries. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN, CD209) in humans was showed to trigger an anti-inflammatory cascade and associated with KD susceptibility. This study was conducted to investigate the association...

Increased Risk of Atopic Dermatitis in Preschool Children with Kawasaki Disease: A Population-Based Study in Taiwan

 Sukhontip Klahan,2 Ying-Hsien Huang,8 Wei-Pin Chang,7 and Ho-Chang Kuo8 1Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 97004, Taiwan 2Department of Clinical Pharmacy, Taipei

Increased Risk of Atopic Dermatitis in Preschool Children with Kawasaki Disease: A Population-Based Study in Taiwan

 Sukhontip Klahan,2 Ying-Hsien Huang,8 Wei-Pin Chang,7 and Ho-Chang Kuo8 1Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 97004, Taiwan 2Department of Clinical Pharmacy, Taipei

Plasma Clusterin Concentrations May Predict Resistance to Intravenous Immunoglobulin in Patients with Kawasaki Disease

, Chih-Cheng Chen, Ying-Hsien Huang, Ying-Jui Lin, and Hong-Ren Yu Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, 123 Ta-Pei Road, Niao-Sung

Associations of Mitochondrial Haplogroups B4 and E with Biliary Atresia and Differential Susceptibility to Hydrophobic Bile Acid

Mitochondrial dysfunction has been implicated in the pathogenesis of biliary atresia (BA). This study aimed to determine whether a specific mitochondrial DNA haplogroup is implicated in the pathogenesis and prognosis of BA. We determined 40 mitochondrial single nucleotide polymorphisms in 15 major mitochondrial haplogroups by the use of 24-plex PCR and fluorescent beads combined...

Sonographic Gallbladder Abnormality Is Associated with Intravenous Immunoglobulin Resistance in Kawasaki Disease

Objective. Kawasaki disease (KD) is an acute systematic vasculitis in children which causes coronary arterial lesions and hydrops of gallbladder. Our objective is to correlate the clinical significance and influence on disease outcome of patients with gallbladder abnormalities in Kawasaki dissease. Methods. Children who met KD diagnosis criteria and were admitted for IVIG...

CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population

-Chyn Chao,2,3 Yu-Wen Hsu,4 Ying-Chi Lin,3 Ying-Hsien Huang,1 Hong-Ren Yu,1 Ming-Feng Hou,5,6 Chi-Di Liang,1 Kuender D. Yang,7 Wei-Chiao Chang,4,5 and Chih-Lu Wang8 1Department of Pediatrics, Kaohsiung ... -Hsien Huang,1 Hong-Ren Yu,1 Ming-Feng Hou,5,6 Chi-Di Liang,1 Kuender D. Yang,7 Wei-Chiao Chang,4,5 and Chih-Lu Wang8 1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung

Polymorphisms of transforming growth factor-β signaling pathway and Kawasaki disease in the Taiwanese population

ScholarSearch for Jin-Ding Huang in:Nature Research journals • PubMed • Google ScholarSearch for Ying-Hsien Huang in:Nature Research journals • PubMed • Google ScholarSearch for Ya-Ling Yang in:Nature Research

Liver Hepcidin and Stainable Iron Expression in Biliary Atresia

Hepcidin is a proposed mammalian host defense peptide that was identified on the basis of its antimicrobial activity, but it was later shown to be a crucial regulator of iron homeostasis and a mediator of the anemia of chronic inflammation. Hepcidin and stainable iron expression in biliary atresia (BA) were investigated in this study. Fresh liver tissues were obtained from 10...