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Association between B Vitamins Supplementation and Risk of Cardiovascular Outcomes: A Cumulative Meta-Analysis of Randomized Controlled Trials

Background Observational studies suggest that B vitamin supplementation reduces cardiovascular risk in adults, but this association remains controversial. This study aimed to summarize the evidence from randomized controlled trials (RCTs) investigating B vitamin supplementation for the primary or secondary prevention of major adverse cardiovascular outcomes and to perform a...

Effect of statins on cardiovascular events in patients with mild to moderate chronic kidney disease: a systematic review and meta-analysis of randomized clinical trials

Background Statins are commonly used to lower total cholesterol levels in the general population to prevent cardiovascular events. However, the effects of statins in patients with chronic kidney disease remain unclear. We therefore performed a meta-analysis to assess the effects of statin therapy on cardiovascular outcomes in patients with mild to moderate chronic kidney disease...

Lipid management in the prevention of stroke: a meta-analysis of fibrates for stroke prevention

(Fei-Fei Yu and Ying-Yi. Qin) with a standardized approach, and any disagreement between these 2 authors was settled by a third author (Yu-Hao. Zhou) until a consensus was reached. This review was ... 3,279 identified studies were reviewed by 2 authors (Xiao-Fei Ye and Xiao Zhang) independently. Other two investigators (Ying-Yi Qin and Jian Lu) independently checked each full-text trial for eligibility

Lipid management in the prevention of stroke: a meta-analysis of fibrates for stroke prevention

undertaken independently by 2 authors (Fei-Fei Yu and Ying-Yi. Qin) with a standardized approach, and any disagreement between these 2 authors was settled by a third author (Yu-Hao. Zhou) until a consensus was ... collection and quality assessment 3,279 identified studies were reviewed by 2 authors (Xiao-Fei Ye and Xiao Zhang) independently. Other two investigators (Ying-Yi Qin and Jian Lu) independently checked each

Trends in In-Hospital Mortality among Patients with Stroke in China

Background The incidence and burden of stroke in China is increasing rapidly. However, little is known about trends in mortality during stroke hospitalization. The objectives of this study were to assess trends of in-hospital mortality among patients with stroke and explore influence factors of in-hospital death after stroke in China. Methods 109 grade III class A hospitals were...

Effects of Combined Aspirin and Clopidogrel Therapy on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

Background Aspirin and clopidogrel monotherapies are effective treatments for preventing vascular disease. However, new evidence has emerged regarding the use of combined aspirin and clopidogrel therapy to prevent cardiovascular events. We therefore performed a comprehensive systematic review and meta-analysis to evaluate the benefits and harms of combined aspirin and clopidogrel...

Effect of Folic Acid Supplementation on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

(Checklist S1) [16]. The literature search was undertaken independently by 2 authors (Chao Wang and Ying-Yi. Qin) with a standardized approach, and any disagreement between these 2 authors was settled by a

Adjuvant Chemotherapy, with or without Taxanes, in Early or Operable Breast Cancer: A Meta-Analysis of 19 Randomized Trials with 30698 Patients

Background Taxanes have been extensively used as adjuvant chemotherapy for the treatment of early or operable breast cancer, particularly in high risk, node-negative breast cancer. Previous studies, however, have reported inconsistent findings regarding their clinical efficacy and safety. We investigated disease-free survival (DFS), overall survival (OS), and drug-related...

Steroids in the Treatment of IgA Nephropathy to the Improvement of Renal Survival: A Systematic Review and Meta-Analysis

Background Studies have shown that steroids can improve kidney survival and decrease the risk of proteinuria in patients with Immunoglobulin A nephropathy, but the overall benefit of steroids in the treatment of Immunoglobulin A nephropathy remains controversial. The aim of this study was to evaluate the benefits and risks of steroids for renal survival in adults with...