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Search: authors:"Ying-shi Ji"

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Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes

PurposePodocytes are terminally differentiated cells lining the Bowman’s capsule. Podocytes are critical for the proper glomerular filtration barrier function. At the same time, autophagy is crucial for maintaining podocyte homeostasis and insufficient autophagy could cause podocyte loss and proteinuria that is commonly observed in diabetic nephropathy (DN).MethodsIn this study...