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Search: authors:"Yogesh Singh"

13 papers found.
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Downregulation of endometrial mesenchymal marker SUSD2 causes cell senescence and cell death in endometrial carcinoma cells

, or preparation of the manuscript. Author Contributions Conceptualization: Shaqiu Zhang, Ni Zeng. Formal analysis: Shaqiu Zhang, Nour Alowayed, Yogesh Singh, Anchun Cheng. Funding acquisition ... : Florian Lang, Madhuri S. Salker. Investigation: Shaqiu Zhang, Ni Zeng, Nour Alowayed, Yogesh Singh, Anchun Cheng, Madhuri S. Salker. Methodology: Nour Alowayed. Project administration: Florian Lang

Pressure-driven collapse of the relativistic electronic ground state in a honeycomb iridate

Search for Yogesh Singh in:Nature Research journals • PubMed • Google Scholar Search for Serge Desgreniers in:Nature Research journals • PubMed • Google Scholar Search for Kavita Mehlawat in:Nature

Rational design of drug-like compounds targeting Mycobacterium marinum MelF protein

analysis. Data curation: Renu Dharra, Yogesh Singh, Promod K. Mehta. Formal analysis: Renu Dharra, Yogesh Singh, Rani Gupta, Mahesh Kulharia, Promod K. Mehta. Funding acquisition: Amit K. Pandey, Mahesh ... Kulharia, Promod K. Mehta. Investigation: Renu Dharra, Sakshi Talwar, Rani Gupta, Amit K. Pandey, Mahesh Kulharia, Promod K. Mehta. Methodology: Renu Dharra, Sakshi Talwar, Yogesh Singh, Rani Gupta

LeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer Cells

LeftyA, a cytokine regulating stemness and embryonic differentiation, down-regulates cell proliferation and migration. Cell proliferation and motility require actin reorganization, which is under control of ras-related C3 botulinum toxin substrate 1 (Rac1) and p21 protein-activated kinase 1 (PAK1). The present study explored whether LeftyA modifies actin cytoskeleton, shape and...

Identifying influential metrics in the combined metrics approach of fault prediction

Fault prediction is a pre-eminent area of empirical software engineering which has witnessed a huge surge over the last couple of decades. In the development of a fault prediction model, combination of metrics results in better explanatory power of the model. Since the metrics used in combination are often correlated, and do not have an additive effect, the impact of a metric on...

Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy

Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requires prior cellular uptake of glucose. Here we show that both human and murine endometrial epithelial cells express the high affinity Na...

Blunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit Gαi2

Putative functions of the heterotrimeric G-protein subunit Gαi2-dependent signaling include ion channel regulation, cell differentiation, proliferation and apoptosis. Erythrocytes may, similar to apoptosis of nucleated cells, undergo eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine (PS) exposure. Eryptosis may be triggered by...

An Important Role of Prostanoid Receptor EP2 in Host Resistance to Mycobacterium tuberculosis Infection in Mice

Mycobacterium tuberculosis, the causative agent of tuberculosis, resides and replicates within susceptible hosts by inhibiting host antimicrobial mechanisms. Prostaglandin E2 (PGE2), produced by M. tuberculosis–infected macrophages, exerts a variety of immunomodulatory functions via 4 receptors (EP1–EP4), each mediating distinct PGE2 functions. Here, we show that M. tuberculosis...

T Cells from Programmed Death-1 Deficient Mice Respond Poorly to Mycobacterium tuberculosis Infection

Background Programmed Death-1 (PD-1; CD279) receptor molecule is widely believed to be a negative regulator predominantly expressed by exhausted/activated mouse T cells. Upon interaction with its ligands, PD-L1 and PD-L2, PD-1 inhibits activation of T cells and cytokine production, which has been documented in various viral and fungal infections as well as in vitro studies...

Early Secreted Antigen ESAT-6 of Mycobacterium tuberculosis Promotes Protective T Helper 17 Cell Responses in a Toll-Like Receptor-2-dependent Manner

Despite its relatively poor efficacy, Bacillus Calmette-Guérin (BCG) has been used as a tuberculosis (TB) vaccine since its development in 1921. BCG induces robust T helper 1 (Th1) immune responses but, for many individuals, this is not sufficient for host resistance against Mycobacterium tuberculosis (M. tb) infection. Here we provide evidence that early secreted antigenic...

Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss

Decidualization renders the endometrium transiently receptive to an implanting blastocyst although the underlying mechanisms remain incompletely understood. Here we show that human endometrial stromal cells (HESCs) rapidly release IL-33, a key regulator of innate immune responses, upon decidualization. In parallel, differentiating HESCs upregulate the IL-33 transmembrane receptor...