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FMISO accumulation in tumor is dependent on glutathione conjugation capacity in addition to hypoxic state

, Japan 2 & Yoichi Shimizu 3 Graduate School of Medicine, Hokkaido University , Sapporo 060-8638 , Japan 4 Central Institute of Isotope Science, Hokkaido University , Sapporo 060-0815 , Japan 5 Faculty of ... whether FMISO is metabolized to amino-FMISO-GS within tumor cells and how amino-FMISO-GS contributes to FMISO accumulation in hypoxic cells. We also evaluated the relationship - Yukiko Masaki and Yoichi

Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent “Pimonidazole” in Hypoxia

Hypoxia, or low oxygen concentration, is a key factor promoting tumor progression and angiogenesis and resistance of cancer to radiotherapy and chemotherapy. 2-Nitroimidazole-based agents have been widely used in pathological and nuclear medicine examinations to detect hypoxic regions in tumors; in particular, pimonidazole is used for histochemical staining of hypoxic regions. It...

Dynamic PET evaluation of elevated FLT level after sorafenib treatment in mice bearing human renal cell carcinoma xenograft

). Yoichi Shimizu: Ph. D. (Pharmaceutical Sciences), Assistant Professor. Ken-ichi Nishijima: Ph. D. (Pharmaceutical Sciences). Naoki Kubo: Ph. D. (Medical Science), (Specially Appointed) Associate Professor

Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice

Obesity was reported to cause kidney injury by excessive accumulation of sphingolipids such as sphingomyelin and ceramide. Sphingomyelin synthase 2 (SMS2) is an important enzyme for hepatic sphingolipid homeostasis and its dysfunction is considered to result in fatty liver disease. The expression of SMS2 is also high in the kidneys. However, the contribution of SMS2 on renal...