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Knockdown of TRIM65 inhibits autophagy and cisplatin resistance in A549/DDP cells by regulating miR-138-5p/ATG7

Cisplatin resistance is the main cause of treatment failure in patients with non-small-cell lung cancer (NSCLC). Autophagy is a key mechanism of resistance to chemotherapy. Given that tripartite motif (TRIM)-containing proteins are involved in the regulation of autophagy and chemoresistance, we aimed to study the functions of TRIM protein members in autophagy-mediated...

Production of \(Z_c(3900\) ) and \(Z_c(4020)\) in \(B_c\) decay

In the present work, we propose to search the charmonium-like states \(Z_c(3900\)) and \(Z_c(4020)\) in the \(B_c\) decay. In an effective Lagrangian approach, the branching ratios of \(B_c^+ \rightarrow Z_c(3900)^+ \pi ^0\) and \(B_c^+\rightarrow Z_c (4020)^+ \pi ^0\) are estimated to be of order of \(10^{-4}\) and \(10^{-7}\), respectively. The large production rate of \(Z_c...

Fasting apolipoprotein B48 is associated with large artery atherosclerotic stroke: a case-control study

reasonable request. Author Contributions Yong Chen designed, sponsored and guided this study. Jing Tian and Hong Chen measured the plasma ApoB48 levels, collected the clinic data and analyzed the results ... . Ping Liu and Chun Wang evaluated the stroke subtypes separately and help to collect the clinical data and plasma. Jing Tian, Hong Chen and Yong Chen analyzed the data and wrote the manuscript. Ping Liu

Numerical Contour Integral Methods for Free-Boundary Partial Differential Equations Arising in American Volatility Options Pricing

Yong Chen; moc.361@999861gnoynehc Received 15 May 2018; Revised 15 October 2018; Accepted 16 October 2018; Published 4 November 2018 Academic Editor: Yong Zhou Copyright © 2018 Yong Chen and Jianjun

Novel polyclonal antibody-based rapid gold sandwich immunochromatographic strip for detecting the major royal jelly protein 1 (MRJP1) in honey

: Lirong Shen. Project administration: Lirong Shen. Resources: Yifan Zhang. Validation: Yong Chen. Writing ? original draft: Yifan Zhang. Writing ? review & editing: Yifan Zhang. 13 / 15 14 / 15 1

Optimal Control, Safety Technology, and Electromagnetic Compatibility in the Driving System of Electric Vehicle

Engineering, Chongqing Jiaotong University, Chongqing, 400074, China Correspondence should be addressed to Yong Chen; nc.ude.ctseu@dcnehcy Received 9 December 2018; Accepted 9 December 2018; Published 24 ... December 2018 Copyright © 2018 Yong Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction

Optimal Control, Safety Technology, and Electromagnetic Compatibility in the Driving System of Electric Vehicle

Engineering, Chongqing Jiaotong University, Chongqing, 400074, China Correspondence should be addressed to Yong Chen; nc.ude.ctseu@dcnehcy Received 9 December 2018; Accepted 9 December 2018; Published 24 ... December 2018 Copyright © 2018 Yong Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction

miR-10b suppresses cell invasion and metastasis through targeting HOXA3 regulated by FAK/YAP signaling pathway in clear-cell renal cell carcinoma

MicroRNAs have been related to tumor progression in diverse human cancers including clear-cell renal cell carcinoma (ccRCC). Previous study has suggested the important regulation function of miR-10b in ccRCC. However, the direct target of miR-10b in ccRCC and the related molecular mechanisms has not yet been revealed. miR-10b and HOXA3 was detected by qRT-PCR. MTT, colony...

Recovery Performance of Ge-Doped Vertical GaN Schottky Barrier Diodes

Vertical GaN Schottky barrier diodes (SBDs) were fabricated on Ge-doped free-standing GaN substrates. The crystal quality of the SBDs was characterized by cathode luminescence measurement, and the dislocation density was determined to be ~ 1.3 × 106 cm− 2. With the electrical performance measurements conducted, the SBDs show a low turn-on voltage Von (0.70~0.78 V) and high...

Differentiation of human induced pluripotent stem cells into Leydig-like cells with molecular compounds

Scientific Research, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaXianwu Chen, Chao Li, Yong Chen, Leikai Ma, Renshan Ge & Xiaoling ... Research journals • PubMed • Google Scholar Search for Yong Chen in:Nature Research journals • PubMed • Google Scholar Search for Haitao Xi in:Nature Research journals • PubMed • Google Scholar Search for

Simulation and Experimental Study on Vibration and Sound Radiation Control with Piezoelectric Actuators

FEM/BEM is adopted to model the interaction between the fluid and structures. In the modeling, modal truncation and inertial coupling are applied to sufficiently reduce the coupled model order. This approach is adopted for the purpose of constructing a modal model in the time domain. Active vibration control is realized with piezoelectric actuators and an adaptive method. In the...

Simulation and Experimental Study on Vibration and Sound Radiation Control with Piezoelectric Actuators

FEM/BEM is adopted to model the interaction between the fluid and structures. In the modeling, modal truncation and inertial coupling are applied to sufficiently reduce the coupled model order. This approach is adopted for the purpose of constructing a modal model in the time domain. Active vibration control is realized with piezoelectric actuators and an adaptive method. In the...

Rapid detection of colistin resistance protein MCR-1 by LC–MS/MS

BackgroundColistin (polymyxin E) and polymixin B are important bactericidal antibiotics used in the treatment of serious infections caused by multi-drug resistant Gram-negative organisms. Transferrable plasmid-mediated colistin resistance, conferred by the product of the mcr-1 gene, has emerged as a global healthcare threat. Consequently, the rapid detection of the MCR-1 protein...

Rapid detection of colistin resistance protein MCR-1 by LC–MS/MS

Colistin (polymyxin E) and polymixin B are important bactericidal antibiotics used in the treatment of serious infections caused by multi-drug resistant Gram-negative organisms. Transferrable plasmid-mediated colistin resistance, conferred by the product of the mcr-1 gene, has emerged as a global healthcare threat. Consequently, the rapid detection of the MCR-1 protein in...

$$Z_c(3900)/Z_c(3885)$$ as a virtual state from $$\pi J/\psi -\bar{D}^*D$$πJ/ψ-D¯∗D interaction

Eur. Phys. J. C Zc(3900)/Zc(3885) as a virtual state from π J/ψ − D¯ ∗ D interaction Jun He 1 Dian-Yong Chen 0 0 School of Physics, Southeast University , Nanjing 210094 , China 1 Department of

Bovine milk-derived exosomes enhance goblet cell activity and prevent the development of experimental necrotizing enterocolitis

Li, Alison Hock, Richard Y. Wu, Carol Lee, Agostino Pierro. Data curation: Bo Li, Alison Hock, Richard Y. Wu, Adam Minich, Steven R. Botts, Carol Lee, Lina Antounians, Hiromu Miyake, Yuhki Koike, Yong ... Chen. Formal analysis: Bo Li, Richard Y. Wu. Funding acquisition: Agostino Pierro. Methodology: Bo Li, Alison Hock. Supervision: Augusto Zani, Philip M. Sherman, Agostino Pierro. Writing ? original

Researches on Damage Evolution and Acoustic Emission Characteristics of Rocks

Cao Copyright © 2018 Yong Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any

Visualized Emotion Ontology: a model for representing visual cues of emotions

R01LM011829, and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number R01AI130460. Dr. Yong Chen was supported in part by the following NIH grants