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Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-κB/TNF-α Signaling Pathway

Yanli Wang,1 Yuqing Zhang,1 Yu Zhang,1 Wenping Xie,1 Bing Yan,1 Feng Liu,1 Hon-Kan Yip,5 Xi-yong Yu,6 and Yangxin Li1 1Institute for Cardiovascular Science & Department of Cardiovascular Surgery, First

circ-Sirt1 controls NF-κB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells

NF-κB-mediated inflammatory phenotypic switching of vascular smooth muscle cells (VSMCs) plays a central role in atherosclerosis and neointimal formation. However, little is known about the roles of circRNAs in the regulation of NF-κB signaling. Here, we identify the involvement of circ-Sirt1 that was one of transcripts of SIRT1 host gene in VSMC inflammatory response and...

Grinding Chatter Detection and Identification Based on BEMD and LSSVM

University, China, in 1997. His research interests include on reliability and mechanism. Chun-Shao Huang, born in 1976, is currently an engineer at Hangzhou Hangji Machine Tool Co., Ltd., China. Yong-Yu Yi

Hydroxyl super rotors from vacuum ultraviolet photodissociation of water

Hydroxyl radicals (OH) play a central role in the interstellar medium. Here, we observe highly rotationally excited OH radicals with energies above the bond dissociation energy, termed OH “super rotors”, from the vacuum ultraviolet photodissociation of water. The most highly excited OH(X) super rotors identified at 115.2 nm photolysis have an internal energy of 4.86 eV. A...

Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies

, Feng Dong, Michael B. Otteneder. Data curation: Nicole A. Kratochwil, Stephen R. Dueker, Dieter Muri, Claudia Senn, HyeJin Yoon, Byung-Yong Yu, Gwan-Ho Lee, Feng Dong, Michael B. Otteneder. Formal ... analysis: Nicole A. Kratochwil, Stephen R. Dueker, Dieter Muri, Claudia Senn, HyeJin Yoon, Byung-Yong Yu, Gwan-Ho Lee, Michael B. Otteneder. Investigation: Stephen R. Dueker, Feng Dong. Methodology

Degradation Data-Driven Remaining Useful Life Estimation in the Absence of Prior Degradation Knowledge

to Changhua Hu; moc.anis@uer_hch Received 6 August 2017; Accepted 23 October 2017; Published 3 December 2017 Academic Editor: Chunhui Zhao Copyright © 2017 Yong Yu et al. This is an open access

Functional characterization of common BCL11B gene desert variants suggests a lymphocyte-mediated association of BCL11B with aortic stiffness

in:Nature Research journals • PubMed • Google Scholar Search for Yong Yu in:Nature Research journals • PubMed • Google Scholar Search for Pentao Liu in:Nature Research journals • PubMed • Google Scholar

Differential diagnosis between benign and malignant pleural effusion with dual-energy spectral CT

Conceptualization: Xirong Zhang, Taiping He, Ming Zhang. Data curation: Yong Yu, Chunling Ma, Yuxin Lei. Formal analysis: Haifeng Duan. Investigation: Zhanli Ren. Methodology: Xirong Zhang. Resources: Zhanli Ren

High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidation

Francisco, CA, 94143, USAHarrison Liu AuthorsSearch for Yong Yu in:Nature Research journals • PubMed • Google Scholar Search for Ayse Sena Mutlu in:Nature Research journals • PubMed • Google Scholar Search

Investigation of a real-time location system of corneal astigmatic axis

Background To construct a real-time computerized location system (RCLS) to analyze and display the axis of corneal astigmatism and to compare its accuracy with the Scheimpflug method. Methods Fifty-seven eyes of 39 volunteers with corneal astigmatism more than 1.00 diopter (D) were recruited. The RCLS was composed of a circular light-emitting diode (LED) light source, surgical...

Dominant and recessive imprinting of exosomes from parent cells

Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University , Suzhou, Jiangsu 215123 , China 1 Xi-Yong Yu is at the Key Laboratory of Molecular Clinical Pharmacology and

Understanding seed-mediated growth of gold nanoclusters at molecular level

University of Singapore, 4 Engineering Drive 4, Singapore, 117585, SingaporeQiaofeng Yao, Xun Yuan, Yong Yu, David Tai Leong & Jianping XieDepartment of Chemistry, University of California, Riverside, CA ... for Victor Fung in:Nature Research journals • PubMed • Google Scholar Search for Yong Yu in:Nature Research journals • PubMed • Google Scholar Search for David Tai Leong in:Nature Research journals

48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse

Background and Aims. We aimed to ascertain the feasibility and safety of NA cessation, the status of patients after cessation, and the predictive factors for relapse and subsequent retreatment. Methods. A total of 92 patients were enrolled in this prospective study. Patients were monitored every month for the first 3 months after cessation and every 3 months thereafter. Results...

Comparison between toric and spherical phakic intraocular lenses combined with astigmatic keratotomy for high myopic astigmatism

Background To compare the outcomes of a toric phakic intraocular lens (PIOL) and a spherical PIOL combined with astigmatic keratotomy (AK) for the correction of high myopic astigmatism. Methods This study enrolled patients with high myopic astigmatism, including 30 eyes (22 patients) that received a toric PIOL implantation (TICL group), and 32 eyes (24 patients) that received...

Metabolomic mechanisms of gypenoside against liver fibrosis in rats: An integrative analysis of proteomics and metabolomics data

Aims To investigate mechanisms and altered pathways of gypenoside against carbon tetrachloride (CCl4)-induced liver fibrosis based on integrative analysis of proteomics and metabolomics data. Methods CCl4-induced liver fibrosis rats were administrated gypenoside. The anti-fibrosis effects were evaluated by histomorphology and liver hydroxyproline (Hyp) content. Protein profiling...

Diversity of bacterial dimethylsulfoniopropionate degradation genes in surface seawater of Arctic Kongsfjorden

information AffiliationsKey Laboratory for Polar Science of State Oceanic Administration, Polar Research Institute of China, Shanghai 200136, ChinaYin-Xin Zeng, Zong-Yun Qiao, Yong Yu, Hui-Rong Li & Wei Luo ... AuthorsSearch for Yin-Xin Zeng in:Nature Research journals • PubMed • Google ScholarSearch for Zong-Yun Qiao in:Nature Research journals • PubMed • Google ScholarSearch for Yong Yu in:Nature Research journals

Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration

, U1601227 to Dr. Xi-Yong Yu.), the National Institutes of Health grants HL107957, HL110740, HL136025, and HL130042 (to Dr. Yigang Wang), the Science and Technology Programs of Guangdong Province (No ... . 2014A050503047 to Dr. Xiyong Yu and Dr . Yigang Wang , 2015B020225006 to Dr. Xi-Yong Yu), Guangzhou Science and Technology Program (No. 201604010087 to Dr . Xi-Yong Yu.), and the American Heart Association

Benefits of Levothyroxine Replacement Therapy on Nonalcoholic Fatty Liver Disease in Subclinical Hypothyroidism Patients

Objectives. To evaluate the effect of levothyroxine (LT4) replacement therapy on nonalcoholic fatty liver disease (NAFLD) in subclinical hypothyroidism (SCH) patients. Methods. This study was a post hoc analysis of a randomized controlled trial and involved 33 significant and 330 mild SCH patients. All of the significant SCH patients received LT4 supplement. The mild SCH patients...

Improving Image Quality of Bronchial Arteries with Virtual Monochromatic Spectral CT Images

Objective To evaluate the clinical value of using monochromatic images in spectral CT pulmonary angiography to improve image quality of bronchial arteries. Methods We retrospectively analyzed the chest CT images of 38 patients who underwent contrast-enhanced spectral CT. These images included a set of 140kVp polychromatic images and the default 70keV monochromatic images. Using...