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40 papers found.
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pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG

Plasmacytoid dendritic cells (pDCs) express high levels of the toll-like receptors (TLRs) TLR7 and TLR9. In response to TLR7 and TLR9 ligands, pDCs are primary producers of type I interferons. Our previous study demonstrated that pDCs activated by the TLR7 ligand imiquimod (IMQ) and the TLR9 ligand CpG A can kill breast cancer cells in vitro and inhibit tumor growth in vivo...

Creating single Majorana type topological zero mode in superfluids of cold fermionic atoms

We explore the topological phase, which involves Majorana type topological zero mode fermions (MTZFs) at the edge, using d–wave superfluid with Rashba spin-orbit coupling (SOC) interactions. The self-Hermitian of this MTZF( γ † (k)=γ(k)) is similar to that of the Majorana fermions (MFs) ( γ † =γ). We show that, to realize a single MTZF at each edge in superfluid with d–wave...

Guards at the gate: physiological and pathological roles of tissue-resident innate lymphoid cells in the lung

necrosis factor; TSLP, thymic stromal lymphopoietin; VCAM-1, vascular cell adhesion molecule-1 COMPLIANCE WITH ETHICS GUIDELINES Hang Cheng, Chengyan Jin, Jing Wu, Shan Zhu, Yong-Jun Liu, and Jingtao Chen

Structural and functional analyses of human DDX41 DEAD domain

. Yan Jiang, Yanping Zhu, Weicheng Qiu, Yong-Jun Liu, Genhong Cheng, Zhi-Jie Liu, Songying Ouyang declare that they have no conflict of interest. This article does not contain any studies with human or

Structural Characterisation of Asphaltenes during Residue Hydrotreatment with Light Cycle Oil as an Additive

668, Xiamen, Fujian 361021, China Received 23 January 2015; Accepted 5 March 2015 Academic Editor: Tomokazu Yoshimura Copyright © 2015 Yong-Jun Liu and Zhi-Feng Li. This is an open access article

Structural Characterisation of Asphaltenes during Residue Hydrotreatment with Light Cycle Oil as an Additive

668, Xiamen, Fujian 361021, China Received 23 January 2015; Accepted 5 March 2015 Academic Editor: Tomokazu Yoshimura Copyright © 2015 Yong-Jun Liu and Zhi-Feng Li. This is an open access article

Mensenchymal stem cells can delay radiation-induced crypt death: impact on intestinal CD44+ fragments

Intestinal stem cells are primitive cells found within the intestinal epithelium that play a central role in maintaining epithelial homeostasis through self-renewal and commitment into functional epithelial cells. Several markers are available to identify intestinal stem cells, such as Lgr5, CD24 and EphB2, which can be used to sort intestinal stem cells from mammalian gut. Here...

Very-long-range disynaptic V1 connections through layer 6 pyramidal neurons revealed by transneuronal tracing with rabies virus

Very-long-range disynaptic V1 connections through layer 6 pyramidal neurons revealed by transneuronal tracing with rabies virus Yong-Jun Liu, Miguel Arreola, Cassandra M Coleman, David C Lyon

Regulation of TLR7/9 signaling in plasmacytoid dendritic cells

Plasmacytoid dendritic cells (pDCs), also known as type I interferon (IFN)-producing cells, are specialized immune cells characterized by their extraordinary capabilities of mounting rapid and massive type I IFN response to nucleic acids derived from virus, bacteria or dead cells. PDCs selectively express endosomal Toll-like receptor (TLR) 7 and TLR9, which sense viral RNA and...

Death receptor 6 is a novel plasmacytoid dendritic cell-specific receptor and modulates type I interferon production

Plumas, Laurence Chaperot, Yong-jun Liu and Liguo Zhang declare that they have no conflict of interest. Human buffy coats from normal healthy volunteers were obtained from China Red Cross. PBMCs were

Recent advances in the role of toll-like receptors and TLR agonists in immunotherapy for human glioma

Gliomas are extremely aggressive brain tumors with a very poor prognosis. One of the more promising strategies for the treatment of human gliomas is targeted immunotherapy where antigens that are unique to the tumors are exploited to generate vaccines. The approach, however, is complicated by the fact that human gliomas escape immune surveillance by creating an immune suppressed...

Dendritic Cells Regulate Treg-Th17 Axis in Obstructive Phase of Bile Duct Injury in Murine Biliary Atresia

Several cell types are considered to be effector cells in bile duct injury in rhesus rotavirus (RRV)-induced experimental biliary atresia (BA). Here, we identified an increased T helper 17 (Th17) cell population in a BA mode. By depleting the Th17 cells, the BA symptoms (onset of jaundice, acholic stools and retarded growth) were attenuated and the survival rate was improved...

The interaction between the helicase DHX33 and IPS-1 as a novel pathway to sense double-stranded RNA and RNA viruses in myeloid dendritic cells

Institute, Dallas, TX, USALeiyun Weng, Yong-Jun Liu & Zhiqiang Zhang AuthorsSearch for Ying Liu in:Nature Research journals • PubMed • Google ScholarSearch for Ning Lu in:Nature Research journals • PubMed ... journals • PubMed • Google ScholarSearch for Yong-Jun Liu in:Nature Research journals • PubMed • Google ScholarSearch for Zhiqiang Zhang in:Nature Research journals • PubMed • Google Scholar Competing

Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice

The role of plasmacytoid dendritic cells (pDC) in human immunodeficiency virus type 1 (HIV-1) infection and pathogenesis remains unclear. HIV-1 infection in the humanized mouse model leads to persistent HIV-1 infection and immunopathogenesis, including type I interferons (IFN-I) induction, immune-activation and depletion of human leukocytes, including CD4 T cells. We developed a...

Bifunctional fused polypeptide inhibits the growth and metastasis of breast cancer

- deda ropF open access to scientific and medical research O r i g i n a l r e s e a r c h Yong-Jun liu 1–3 1Medical Molecular Diagnostics Key laboratory of guangdong, 2Department of Biochemistry and