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Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH2 on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism

Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH2 on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism Yonggang Zhang,1 Tingrui Ge,1 Ping Xiang,1 ... Editor who approved publication: Dr Anastasios Lymperopoulos Yonggang Zhang,1 Tingrui Ge,1 Ping Xiang,1 Haibing Mao,1 Shumin Tang,1 Aimin Li,2 Lin Lin,3 Yinting Wei4 1Department of

Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis

Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis Dan Liu,1,* Xiaodan Li,2,* Yonggang Zhang,3 Joey Sum-Wing Kwong,4,5 Ling Li,6

Comparison of porous and nano zinc oxide for replacing high-dose dietary regular zinc oxide in weaning piglets

. 31501965) and National Key Research and Development Program of China (2016YFD0501201). Author Yonggang Zhang is employed by Animine Co., Ltd. Animine Co., Ltd provided porous ZnO (HiZox) for this study and ... . Resources: Yonggang Zhang. Supervision: Hengjia Ni, Bin Zhang, Yulong Yin. Writing ± original draft: Lina Long, Hengjia Ni, Yulong Yin. Writing ± review & editing: Hengjia Ni. 11 / 14 12 / 14 31. Zou Y

Plasma Level of Placenta-Derived Macrophage-Stimulating Protein -Chain in Preeclampsia before 20 Weeks of Pregnancy

Object This study aimed to investigate the diagnostic value of placenta-derived macrophage-stimulating protein α-chain (MSP-α) before the 20th week of gestation for the early diagnosis of preeclampsia (PE). Methods and Materials Two parts of this nested case-control study were simultaneously executed, and 1500 pregnant women were recruited. A total of 124 pregnant women were...

The efficacy of negative pressure wound therapy in treating sacroiliac joint tuberculosis with a chronic sinus tract: a case series

Objective Tuberculous sacroiliitis with abscess accounts for approximately 50 % of all sacroiliac joint tuberculosis cases. Tuberculous abscesses spread into the sacroiliac joint capsule, subcutaneous tissue, and the skin, and finally becomes a skin sinus. As there are no previous reports about sacroiliac joint tuberculosis with a chronic sinus, we evaluated its clinical...

CRISPR-CAS9 D10A nickase target-specific fluorescent labeling of double strand DNA for whole genome mapping and structural variation analysis

We have developed a new, sequence-specific DNA labeling strategy that will dramatically improve DNA mapping in complex and structurally variant genomic regions, as well as facilitate high-throughput automated whole-genome mapping. The method uses the Cas9 D10A protein, which contains a nuclease disabling mutation in one of the two nuclease domains of Cas9, to create a guide RNA...

Corrigendum: Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing

Zhang Jonathan Karn Wenhui Hu Kamel Khalili RepoRts “KK, WH, RK, and YZ are named inventors on patents that cover the viral gene editing technology that is the subject of this published journal article

TRAIL Is Decreased Before 20 Weeks Gestation in Women with Hypertensive Disorders of Pregnancy

Objective The present study evaluated maternal plasma protein profiles before the onset of hypertensive disorders of pregnancy (HDP) to assess the relationship between maternal plasma tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and HDP before 20 weeks gestation and to evaluate the discriminatory performance of plasma TRAIL levels for HDP. Methods A 2-phase...

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing

Chen, Tracy Fischer, Alessandro Napoli, Yonggang Zhang, Wenhui Hu & Kamel KhaliliComprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor ... , Philadelphia, PA 19140 USARafal Kaminski, Yilan Chen, Tracy Fischer, Ellen Tedaldi, Alessandro Napoli, Yonggang Zhang, Wenhui Hu & Kamel KhaliliDepartment of Medicine, Temple HIV Program, Lewis Katz School of

A Sarsa(λ) Algorithm Based on Double-Layer Fuzzy Reasoning

Solving reinforcement learning problems in continuous space with function approximation is currently a research hotspot of machine learning. When dealing with the continuous space problems, the classic Q-iteration algorithms based on lookup table or function approximation converge slowly and are difficult to derive a continuous policy. To overcome the above weaknesses, we propose...

CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs

Current antiretroviral therapy does not eliminate the integrated and transcriptionally silent HIV-1 provirus in latently infected cells. Recently, a “shock and kill” strategy has been extensively explored to eradicate the HIV-1 latent reservoirs for a permanent cure of AIDS. The therapeutic efficacy of currently used agents remains disappointing because of low efficiency, non...

New Algorithms for Bidirectional Singleton Arc Consistency

September 2013 Academic Editor: William Guo Copyright © 2013 Yonggang Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

BMI and Coronary Heart Disease Risk Among Low-Income and Underinsured Diabetic Patients

OBJECTIVE The association between obesity and coronary heart disease (CHD) risk remains debatable, and no studies have assessed this association among diabetic patients. The aim of our study was to investigate the association between BMI and CHD risk among patients with type 2 diabetes.

Structural and optical characterizations of InPBi thin films grown by molecular beam epitaxy

InPBi thin films have been grown on InP by gas source molecular beam epitaxy. A maximum Bi composition of 2.4% is determined by Rutherford backscattering spectrometry. X-ray diffraction measurements show good structural quality for Bi composition up to 1.4% and a partially relaxed structure for higher Bi contents. The bandgap was measured by optical absorption, and the bandgap...

Porous Ti6Al4V Scaffold Directly Fabricated by Sintering: Preparation and In Vivo Experiment

The interface between the implant and host bone plays a key role in maintaining primary and long-term stability of the implants. Surface modification of implant can enhance bone ingrowth and increase bone formation to create firm osseointegration between the implant and host bone and reduce the risk of implant losing. This paper mainly focuses on the fabricating of 3-dimensiona...

Selected Lactic Acid-Producing Bacterial Isolates with the Capacity to Reduce Salmonella Translocation and Virulence Gene Expression in Chickens

Background Probiotics have been used to control Salmonella colonization/infection in chickens. Yet the mechanisms of probiotic effects are not fully understood. This study has characterized our previously-selected lactic acid-producing bacterial (LAB) isolates for controlling Salmonella infection in chickens, particularly the mechanism underlying the control. Methodology...

A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation

MicroRNAs (miRNAs) have been implicated in DNA repair pathways through transcriptional responses to DNA damaging agents or through predicted miRNA regulation of DNA repair genes. We hypothesized that additional DNA damage regulating miRNAs could be identified by screening a library of 810 miRNA mimetics for the ability to alter cellular sensitivity to ionizing radiation (IR). A...