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Effects of Meshed p-type Contact Structure on the Light Extraction Effect for Deep Ultraviolet Flip-Chip Light-Emitting Diodes

In this work, flip-chip AlGaN-based deep ultraviolet light-emitting diodes (DUV LEDs) with various meshed contact structures are systematically investigated via three-dimensional finite-difference time-domain (3D FDTD) method. It is observed that both transverse electric (TE)- and transverse magnetic (TM)-polarized light extraction efficiencies (LEEs) are sensitive to the spacing...

Nearly Efficiency-Droop-Free AlGaN-Based Ultraviolet Light-Emitting Diodes with a Specifically Designed Superlattice p-Type Electron Blocking Layer for High Mg Doping Efficiency

This work reports a nearly efficiency-droop-free AlGaN-based deep ultraviolet light-emitting diode (DUV LED) emitting in the peak wavelength of 270 nm. The DUV LED utilizes a specifically designed superlattice p-type electron blocking layer (p-EBL). The superlattice p-EBL enables a high hole concentration in the p-EBL which correspondingly increases the hole injection efficiency...

A Time-Frequency Research for Ultrasonic Guided Wave Generated from the Debonding Based on a Novel Time-Frequency Analysis Technique

Carbon fibre composites have a promising application in the future of the vehicle, because of their high strength and light weight. Debonding is a major defect of the carbon fibre composite. The time-frequency analysis is fundamental to identify the defect on ultrasonic nondestructive evaluation and testing. In order to obtain the instantaneous frequency and the peak time of...

A Time-Frequency Research for Ultrasonic Guided Wave Generated from the Debonding Based on a Novel Time-Frequency Analysis Technique

Carbon fibre composites have a promising application in the future of the vehicle, because of their high strength and light weight. Debonding is a major defect of the carbon fibre composite. The time-frequency analysis is fundamental to identify the defect on ultrasonic nondestructive evaluation and testing. In order to obtain the instantaneous frequency and the peak time of...

Modeling the leaf angle dynamics in rice plant

The leaf angle between stem and sheath (SSA) is an important rice morphological trait. The objective of this study was to develop and validate a dynamic SSA model under different nitrogen (N) rates for selected rice cultivars. The time-course data of SSA were collected in three years, and a dynamic SSA model was developed for different main stem leaf ranks under different N rates...

The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells

Reprogrammed metabolism and redox homeostasis are potential targets of cancer therapy. Our previous study demonstrated that the kidney form of glutaminase (GLS1) is highly expressed in hepatocellular carcinoma (HCC) cells and can be used as a target for effective anticancer therapy. Dihydroartemisinin (DHA) increases intracellular reactive oxygen species (ROS) levels leading to...

A three-terminal ultraviolet photodetector constructed on a barrier-modulated triple-layer architecture

Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, People’s Republic of ChinaDaqian Ye, Zengxia Mei, Huili Liang, Lishu liu, Yonghui Zhang, Junqiang Li ... Huili Liang in:Nature Research journals • PubMed • Google ScholarSearch for Lishu liu in:Nature Research journals • PubMed • Google ScholarSearch for Yonghui Zhang in:Nature Research journals • PubMed

Determining structural ensembles of flexible multi-domain proteins using small-angle X-ray scattering and molecular dynamics simulations

for the Doctoral Program of Higher Education (Grant 20113402120013), and the Fundamental Research Funds for the Central Universities (WK2070000020). Yonghui Zhang, Bin Wen, Junhui Peng, Xiaobing Zuo

Application of the analytic hierarchy approach to the risk assessment of Zika virus disease transmission in Guangdong Province, China

Background An international spread of Zika virus (ZIKV) infection has attracted global attention in 2015. The infection also affected Guangdong province, which is located in southern China. Multiple factors, including frequent communication with South America and Southeast Asia, suitable climate (sub-tropical) for the habitat of Aedes species, may increase the risk of ZIKV...

Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity

Zoledronate is a bisphosphonate that is widely used in the treatment of metabolic bone diseases. However, zoledronate induces significant nephrotoxicity associated with acute tubular necrosis and renal fibrosis when administered intravenously. There is speculation that zoledronate-induced nephrotoxicity may result from its pharmacological activity as an inhibitor of the...

Antioxidant Lignans and Neolignans from Acorus tatarinowii

in:Nature Research journals • PubMed • Google ScholarSearch for Guang Du in:Nature Research journals • PubMed • Google ScholarSearch for Yonghui Zhang in:Nature Research journals • PubMed • Google Scholar ... authors reviewed the manuscript. Competing interests The authors declare no competing financial interests. Corresponding authors Correspondence to Guang Du or Yonghui Zhang. Supplementary information

Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales)

ScholarSearch for Yonghui Zhang in:Nature Research journals • PubMed • Google Scholar Contributions C.C. and Q.T. contributed equally to this work. C.C. and H.Z. performed the main experiments, analyzed the data ... declare no competing financial interests. Corresponding authors Correspondence to Jianping Wang or Yanyan Wang or Yonghui Zhang. Supplementary information PDF files1.Supplementary Information

Identification of ULK1 as a novel biomarker involved in miR-4487 and miR-595 regulation in neuroblastoma SH-SY5Y cell autophagy

Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, ChinaYi Chen, Shuya Wang, Lan Zhang, Tao Xie, Sicheng Song, Yonghui Zhang, Liang Ouyang & Bo LiuNorthwestern University, Feinberg School of ... • Google ScholarSearch for Yonghui Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Liang Ouyang in:Nature Research journals • PubMed • Google ScholarSearch for Bo Liu in:Nature Research

The diminishing socioeconomic disparity in obesity in a Chinese population with rapid economic development: analysis of serial cross-sectional health survey data 2002–2010

Background Social changes and economic development are associated with obesity epidemic. This study is to investigate the trends of socio-economic disparity in obesity from 2002 to 2010 in a Chinese population experiencing the world’s fastest economic development. Methods Four standardized surveys were conducted in a population of 85 million residents in Guangdong, China between...

A large temperature fluctuation may trigger an epidemic erythromelalgia outbreak in China

, 4111, AustraliaShannon RutherfordQueensland University of Technology, Brisbane, AustraliaShilu Tong AuthorsSearch for Tao Liu in:Nature Research journals • PubMed • Google ScholarSearch for Yonghui Zhang

Protective effect of exclusive breastfeeding against hand, foot and mouth disease

Background Infants who are exclusively breastfed receive natural protection against some infectious agents. This study examined whether there was protective effect of exclusive breastfeeding on the occurrence of hand, foot and mouth disease, which was an emerging infectious disease among children in China. Methods A community-based case–control study was carried out among...

A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/β-catenin signaling

Aberrant activation of Wnt signaling pathway is crucial for the onset and progression of human colorectal cancer (CRC). Owing to the persistent dependence on Wnt signaling for growth and survival, inhibition of this pathway is an attractive approach for new therapies. 11α, 12α-epoxyleukamenin E (EPLE) is a novel ent-kaurane diterpenoid that we previously isolated from Salvia...

Salidroside Stimulates Mitochondrial Biogenesis and Protects against H2O2-Induced Endothelial Dysfunction

 Gao Xu,1,2 Yonghui Zhang,1,2 and Si Jin1,2 1Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2The Key Laboratory of Drug Target

Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China

Background An influenza H3N2 epidemic occurred throughout Southern China in 2012. Methods We analyzed the hemagglutinin (HA) and neuraminidase (NA) genes of influenza H3N2 strains isolated between 2011–2012 from Guangdong. Mutation sites, evolutionary selection, antigenic sites, and N-glycosylation within these strains were analyzed. Results The 2011–2012 Guangdong strains...