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CD146: a potential therapeutic target for systemic sclerosis

, Xiaofeng Zeng and Xiyun Yan designed the experiments. Lingling Zhang, Yongting Luo, Xiao Teng, Zhenzhen Wu and Fei Wang performed all the experiments, analyzed and interpreted the data, Mengtao Li, Dong Xu ... , Qian Wang collected patients materials, Lingling Zhang, Yongting Luo, Jing Feng, Xiaofeng Zeng and Xiyun Yan wrote the manuscript, which all authors edited and approved. Lingling Zhang, Yongting Luo

CD146 is essential for PDGFRβ-induced pericyte recruitment

. Jianan Chen and Yongting Luo have contributed equally to this work. Electronic supplementary material The online version of this article (doi:10.1007/s13238-017-0484-5) contains supplementary material

CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis

, ChinaHuiwen Yan, Zhaoqing Wang, Tao Tu, Hongxia Duan, Yongting Luo, Jing Feng & Xiyun YanState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101 ... Tao Tu in:Nature Research journals • PubMed • Google Scholar Search for Hongxia Duan in:Nature Research journals • PubMed • Google Scholar Search for Yongting Luo in:Nature Research journals • PubMed

CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development

Angiogenesis, a process that newly-formed blood vessels sprout from pre-existing ones, is vital for vertebrate development and adult homeostasis. Previous studies have demonstrated that the neuronal guidance molecule netrin-1 participates in angiogenesis and morphogenesis of the vascular system. Netrin-1 exhibits dual activities in angiogenesis: either promoting or inhibiting...

CD146 Deletion in the Nervous System Impairs Appetite, Locomotor Activity and Spatial Learning in Mice

Cell adhesion molecules (CAMs) are crucial effectors for the development and maintenance of the nervous system. Mutations in human CAM genes are linked to brain disorders and psychological diseases, and CAM knockout mice always exhibit similar behavioral abnormalities. CD146 is a CAM of the immunoglobulin superfamily that interacts with Neurite Outgrowth Factor and involved in...

Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice

, Hongxia Duan, Xuan Jiang, Tao Tu, Di Lu, Yongting Luo, Ping Wang, Lina Song, Jing Feng, Dongling Yang and Xiyun Yan declare that they have no conflict of interest. All institutional and national guidelines