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32 papers found.
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Genomic alterations of ground-glass nodular lung adenocarcinoma

Shim 3 HoYun Lee 4 Kyung Soo Lee 4 Yoon-La Choi 5 Woong-Yang Park 1 D. Neil Hayes 6 Sang-Won Um 0 0 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center

Unforeseen clonal evolution of tumor cell population in recurrent and metastatic dermatofibrosarcoma protuberans

. Data curation: Sang Yun Ha, Ji-Young Song, Yu Jin Kim, Eun Hee Lee, Jeeyun Lee, Yoon-La Choi. Formal analysis: Ensel Oh, Mi Jeong Kwon, Ji-Young Song, Jong-Sun Choi, Yoon-La Choi. Funding acquisition ... : Yoon-La Choi, Young Kee Shin. Investigation: Hae Min Jeong. Project administration: Ensel Oh, Young Kee Shin. Resources: Sang Yun Ha. Supervision: Young Kee Shin. Validation: Hae Min Jeong, Mi Jeong

Multi-omics profiling of younger Asian breast cancers reveals distinctive molecular signatures

Breast cancer (BC) in the Asia Pacific regions is enriched in younger patients and rapidly rising in incidence yet its molecular bases remain poorly characterized. Here we analyze the whole exomes and transcriptomes of 187 primary tumors from a Korean BC cohort (SMC) enriched in pre-menopausal patients and perform systematic comparison with a primarily Caucasian and post...

MMP11 and CD2 as novel prognostic factors in hormone receptor-negative, HER2-positive breast cancer

previous study. We then analyzed the association between their expression, measured by quantitative real-time reverse transcription-PCR in formalinJinil Han and Yoon-La Choi have contributed equally to this

Comparison of Accuracy of Whole-Exome Sequencing with Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tissue Samples

Formalin fixing with paraffin embedding (FFPE) has been a standard sample preparation method for decades, and archival FFPE samples are still very useful resources. Nonetheless, the use of FFPE samples in cancer genome analysis using next-generation sequencing, which is a powerful technique for the identification of genomic alterations at the nucleotide level, has been...

The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor�positive breast cancer by expansion of stem-like cancer cells

Introduction The forkhead transcription factor FOXM1 coordinates expression of cell cycle�related genes and plays a pivotal role in tumorigenesis and cancer progression. We previously showed that FOXM1 acts downstream of 14-3-3? signaling, the elevation of which correlates with a more aggressive tumor phenotype. However, the role that FOXM1 might play in engendering resistance to...

A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2− early breast cancer

• PubMed • Google ScholarSearch for Byung-Ho Nam in:Nature Research journals • PubMed • Google ScholarSearch for Seok Jin Nam in:Nature Research journals • PubMed • Google ScholarSearch for Yoon-La Choi

CD24 Overexpression Is Associated with Poor Prognosis in Luminal A and Triple-Negative Breast Cancer

CD24 is associated with unfavourable prognoses in various cancers, but the prevalence of CD24 expression and its influence on clinical outcome in subtypes of breast cancers remain unclear. CD24 expression was analyzed by immunohistochemistry in 747 breast cancer tissues, and DNA methylation and histone modification status in the promoter region of CD24 were assessed using...

Targeted Inhibition of FAK, PYK2 and BCL-XL Synergistically Enhances Apoptosis in Ovarian Clear Cell Carcinoma Cell Lines

Ovarian clear cell carcinoma (OCCC) displays a higher resistance to first line chemotherapy, requiring the development of new therapeutics. We previously identified a frequent chromosomal gain at 8q24 that harbors the focal-adhesion kinase (FAK) gene; the potential of this gene as a therapeutic target remains to be evaluated in OCCCs. We first examined the dependence of OCCCs on...

Prevalence and detection of low-allele-fraction variants in clinical cancer samples

Author notes Hyun-Tae Shin, Yoon-La Choi, Jae Won Yun and Nayoung K.D. Kim contributed equally to this work. AffiliationsSamsung Genome Institute, Samsung Medical Center, Seoul, 06351, KoreaHyun-Tae Shin ... ParkSamsung Advanced Institute of Health Science and Technology, Sungkyunkwan University, Seoul, 06351, KoreaHyun-Tae Shin, Yoon-La Choi, Jae Won Yun, Jae-Yong Nam, Chung Lee, Daeun Ryu & Woong-Yang

Genetic Aberrations in Imatinib-Resistant Dermatofibrosarcoma Protuberans Revealed by Whole Genome Sequencing

Dermatofibrosarcoma protuberans (DFSP) is a very rare soft tissue sarcoma. DFSP often reveals a specific chromosome translocation, t(17;22)(q22;q13), which results in the fusion of collagen 1 alpha 1 (COL1A1) gene and platelet-derived growth factor-B (PDGFB) gene. The COL1A1-PDGFB fusion protein activates the PDGFB receptor and resultant constitutive activation of PDGFR receptor...

Quantitative CT Variables Enabling Response Prediction in Neoadjuvant Therapy with EGFR-TKIs: Are They Different from Those in Neoadjuvant Concurrent Chemoradiotherapy?

Background and Purpose To correlate changes of various CT parameters after the neoadjuvant treatment in patients with lung adenocarcinoma with pathologic responses, focused on their relationship with different therapeutic options, particularly of EGFR-TKI and concurrent chemoradiation therapy (CCRT) settings. Materials and Methods We reviewed pre-operative CT images of primary...

CDK4 Amplification Predicts Recurrence of Well-Differentiated Liposarcoma of the Abdomen

Background The absence of CDK4 amplification in liposarcomas is associated with favorable prognosis. We aimed to identify the factors associated with tumor recurrence in patients with well-differentiated (WD) and dedifferentiated (DD) liposarcomas. Methods From 2000 to 2010, surgical resections for 101 WD and DD liposarcomas were performed. Cases in which complete surgical...

EGFR Mutation Testing in Patients with Advanced Non-Small Cell Lung Cancer: A Comprehensive Evaluation of Real-World Practice in an East Asian Tertiary Hospital

-La Choi Jong-Mu Sun Juhee Cho Sanjay Rampal Joungho Han Bhash Parasuraman Eliseo Guallar Genehee Lee Jeeyun Lee Young Mog Shim Balraj Mittal, Sanjay Gandhi Medical Institute, India Introduction

Aberrant CDK4 Amplification in Refractory Rhabdomyosarcoma as Identified by Genomic Profiling

Yoon-La Choi in:Nature Research journals • PubMed • Google Scholar Contributions J.L. and Y.C. conceived the idea and designed the study. S.P. and J.L. collected and analyzed data, and S.P. and I.D ... the manuscript. Competing interests The authors declare no competing financial interests. Corresponding authors Correspondence to Jeeyun Lee or Yoon-La Choi. Supplementary information PDF files1

Molecular profiles of EGFR, K-ras, c-met, and FGFR in pulmonary pleomorphic carcinoma, a rare lung malignancy

Background Pulmonary pleomorphic carcinoma (PPC) is a rare type of lung cancer characterized by the poor response to conventional chemotherapy and subsequent disappointing outcomes. Therefore, it is paramount to delineate the molecular characteristics of this disease entity. Methods In this study, we retrospectively examined the surgical specimens of 61 patients who underwent...

Favorable response to doxorubicin combination chemotherapy does not yield good clinical outcome in patients with metastatic breast cancer with triple-negative phenotype

Background We analyzed the responses to first line treatment and clinical outcomes of metastatic breast cancer patients treated with palliative doxorubicin/cyclophosphamide (AC) according to molecular cancer subtype. Methods A retrospective analysis was performed for 110 metastatic breast cancer patients selected on the basis of palliative AC treatment and the availability of...

Liposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy

Background Prognosis and optimal treatment strategies of liposarcoma have not been fully defined. The purpose of this study is to define the distinctive clinical features of liposarcomas by assessing prognostic factors. Methods Between January 1995 and May 2008, 94 liposarcoma patients who underwent surgical resection with curative intent were reviewed. Results Fifty patients (53...

Comparative Profiling of Primary Colorectal Carcinomas and Liver Metastases Identifies LEF1 as a Prognostic Biomarker

Purpose We sought to identify genes of clinical significance to predict survival and the risk for colorectal liver metastasis (CLM), the most common site of metastasis from colorectal cancer (CRC). Patients and Methods We profiled gene expression in 31 specimens from primary CRC and 32 unmatched specimens of CLM, and performed Significance Analysis of Microarrays (SAM) to...

Low SP1 Expression Differentially Affects Intestinal-Type Compared with Diffuse-Type Gastric Adenocarcinoma

Specificity protein 1 (SP1) is an essential transcription factor that regulates multiple cancer-related genes. Because aberrant expression of SP1 is related to cancer development and progression, we focused on SP1 expression in gastric carcinoma and its correlation with disease outcomes. Although patient survival decreased as SP1 expression increased (P<0.05) in diffuse-type...