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Search: authors:"Yoshiki Nakashima"

4 papers found.
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Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA

Miyagi-Shiohira, Yoshiki Nakashima & Hirofumi NoguchiOkayama Saidaiji Hospital, Okayama, 704-8192, JapanNaoya KobayashiDivision of Pediatric Dentistry, Graduate School of Medical and Dental Science ... AuthorsSearch for Chika Miyagi-Shiohira in:Nature Research journals • PubMed • Google Scholar Search for Yoshiki Nakashima in:Nature Research journals • PubMed • Google Scholar Search for Naoya Kobayashi

Modified cell-permeable JNK inhibitors efficiently prevents islet apoptosis and improves the outcome of islet transplantation

Naoya Kobayashi Issei Saitoh Chika Miyagi-Shiohira Yoshiki Nakashima Nana Ebi Eri Hamada 0 & Masami Watanabe OPEN We previously reported that treatment with a JNK inhibitory peptide (11R-JNKI) prevents

RCAN-11R peptide provides immunosuppression for fully mismatched islet allografts in mice

Calcineurin inhibitors have been used for transplant therapy. However, the inhibition of calcineurin outside the immune system has a number of side effects. We previously developed a cell-permeable inhibitor of NFAT (nuclear factor of activated T cells) using the polyarginine peptide delivery system. This peptide (11R-VIVIT) selectively interferes with calcineurin-NFAT...

Stimulation of Osteoclast Formation by RANKL Requires Interferon Regulatory Factor-4 and Is Inhibited by Simvastatin in a Mouse Model of Bone Loss

Diseases of bone loss are a major public health problem. Here, we report the novel therapeutic action of simvastatin in osteoclastogenesis and osteoprotection, demonstrated by the ability of simvastatin to suppress osteoclast formation in vitro and in vivo. We found that in vitro, IRF4 expression is upregulated during osteoclast differentiation induced by RANKL (receptor...