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Short-Term PTH(1-34) Therapy in Children to Correct Severe Hypocalcemia and Hyperphosphatemia due to Hypoparathyroidism: Two Case Studies

 Kristen Hook,4 Youngki Kim,5 and Anna Petryk3 1St John’s Medical College, Bangalore, India 2Pediatric Endocrinology, Park Nicollet, Minneapolis, MN, USA 3Pediatric Endocrinology, University of Minnesota

Short-Term PTH(1-34) Therapy in Children to Correct Severe Hypocalcemia and Hyperphosphatemia due to Hypoparathyroidism: Two Case Studies

The standard treatment of hypoparathyroidism is to control hypocalcemia using calcitriol and calcium supplementation. However, in severe cases this approach is insufficient, and the risks of intravenous (i.v.) calcium administration and prolonged hospitalization must be considered. While the use of recombinant human parathyroid hormone 1-34 [rhPTH(1-34)] for long-term control of...

Frontal White Matter Alterations in Short-Term Medicated Panic Disorder Patients without Comorbid Conditions: A Diffusion Tensor Imaging Study

The frontal cortex might play an important role in the fear network, and white matter (WM) integrity could be related to the pathophysiology of panic disorder (PD). A few studies have investigated alterations of WM integrity in PD. The aim of this study was to determine frontal WM integrity differences between patients with PD without comorbid conditions and healthy control (HC...

Angiotensin II receptor blocker pretreatment of rats undergoing sudden renal ablation

Background. Subtotal nephrectomy (N) in rats results in progressive hypertension, proteinuria and renal lesions. Renin–angiotensin system blockade initiated at N prevents these changes; treatments failing to reduce hypertension and proteinuria do not.

Gene Expression Differences in Skin Fibroblasts in Identical Twins Discordant for Type 1 Diabetes

M. Luiza Caramori Youngki Kim Jason H. Moore Stephen S. Rich Josyf C. Mychaleckyj Nobuaki Kikyo Michael Mauer Clinical studies suggest metabolic memory to hyperglycemia. We tested whether diabetes

Pneumococcal Peptidoglycan-Polysaccharides Regulate Toll-Like Receptor 2 in the Mouse Middle Ear Epithelial Cells

• Google ScholarSearch for Katsuhiro Toyama in:Nature Research journals • PubMed • Google ScholarSearch for Youngki Kim in:Nature Research journals • PubMed • Google ScholarSearch for Patricia Ferrieri

Podocyte Detachment and Reduced Glomerular Capillary Endothelial Fenestration in Human Type 1 Diabetic Nephropathy

The aim of this study was to investigate the structural characteristics of podocytes and endothelial cells in diabetic nephropathy. We studied 18 patients with type 1 diabetes (seven normoalbuminuric, six microalbuminuric, and five proteinuric), and six normal control subjects. Groups were not different for age. Type 1 diabetic groups were not different for diabetes duration or...

Cellular basis of diabetic nephropathy: IV Antioxidant enzyme mRNA expression levels in skin fibroblasts of type 1 diabetic sibling pairs

Background. Blunted cultured skin fibroblast (SF) antioxidant enzyme responses to hyperglycaemia are associated with diabetic nephropathy risk. The present study explores whether this association is, at least in part, genetically determined. Methods. We measured glomerular structure and SF mRNA expression for catalase and glutathione peroxidase in 21 sibling pairs concordant for...

Diabetic Nephropathy Is Associated With Gene Expression Levels of Oxidative Phosphorylation and Related Pathways

The in vitro behavior of skin fibroblasts from patients with or without diabetic nephropathy is associated with diabetic nephropathy risk. Here we compared skin fibroblast gene expression profiles from two groups of type 1 diabetic patients: 20 with very fast (“fast-track”) versus 20 with very slow (“slow-track”) rates of development of diabetic nephropathy lesions. Gene...

Pneumococcus Activation of the 5-Lipoxygenase Pathway and Production of Glycoproteins in the Middle Ear of Rats

Pneumococcal otitis media is associated with the production of potent inflammatory mediators (leukotrienes), but the mechanism by which pneumococcus induces production of leukotrienes in the middle ear is poorly understood. In this study, up-regulation of 2 genes that govern the lipoxygenase pathway, cPLA2 and 5-LOX, was observed in rats following inoculation of pneumococcus into...

Induction of Mucin Gene Expression in Middle Ear of Rats by Tumor Necrosis Factor—α: Potential Cause for Mucoid Otitis Media

Mucoid otitis media (MOM) is characterized by viscous fluid, high in mucin concentration, which accumulates in the middle ear cavity. Recent studies suggest that initial infection in the middle ear cleft may be key to the development of MOM. However, factors of the initial infection attributed to the stimulation of mucin production are not clearly understood. This study...

Cellular Basis of Diabetic Nephropathy: 1. Study Design and Renal Structural-Functional Relationships in Patients With Long-Standing Type 1 Diabetes

M. Luiza Caramori Youngki Kim Chunmei Huang Alfred J. Fish Stephen S. Rich Michael E. Miller Greg Russell Michael Mauer - This study was designed to elucidate the cellular basis of risk of or

Cellular Basis of Diabetic Nephropathy: II. The Transforming Growth Factor-β System and Diabetic Nephropathy Lesions in Type 1 Diabetes

Transforming growth factor-β (TGF-β) may be critical in the development of diabetic nephropathy (DN), and genetic predisposition is an important determinant of DN risk. We evaluated mRNA expression levels of TGF-β system components in cultured skin fibroblasts (SFs) from type 1 diabetic patients with fast versus slow development of DN. A total of 125 long-standing type 1 diabetic...