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Beyond Conventional Security in Sponge-Based Authenticated Encryption Modes

The Sponge function is known to achieve \(2^{c/2}\) security, where c is its capacity. This bound was carried over to its keyed variants, such as SpongeWrap, to achieve a \(\min \{2^{c/2},2^\kappa \}\) security bound, with \(\kappa \) the key length. Similarly, many CAESAR competition submissions were designed to comply with the classical \(2^{c/2}\) security bound. We show that...

Neurofilament heavy polypeptide protects against reduction in synaptopodin expression and prevents podocyte detachment

Podocytes are highly specialized cells that line the glomerulus of the kidney and play a role in filtration. Podocyte injury plays a critical role in the development of many kidney diseases, but the underlying mechanisms remain unclear. In this study, we identified that neurofilament heavy polypeptide (NEFH), an intermediate filament component, protects podocyte from injury. We...

PD-L1/PD-L2-expressing B-1 cells inhibit alloreactive T cells in mice

B cells constitute a complex system of antigen-presenting cells (APCs) and exist as distinct subsets that differ in their lineage affiliation, surface molecule expression, and biological function, thus potentially regulating the immune response. In this study, we investigated the immune-regulatory roles of murine B cell subsets as regulatory APCs targeting alloreactive T cells...

Diagnosis and treatment of eosinophilic esophagitis in clinical practice

esophageal cancer. Compliance with ethical standards Conflict of Interest: Yasuhiko Abe, Yu Sasaki, Makoto Yagi, Takao Yaoita, Shoichi Nishise, and Yoshiyuki Ueno have no conflict of interest. Human Rights

Rac1 in podocytes promotes glomerular repair and limits the formation of sclerosis

Rac1, a Rho family member, is ubiquitously expressed and participates in various biological processes. Rac1 expression is induced early in podocyte injury, but its role in repair is unclear. To investigate the role of Rac1 expression in podocytes under pathological conditions, we used podocyte-specific Rac1 conditional knock-out (cKO) mice administered adriamycin (ADR), which...

NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease

-RR12088, S10 RR12964 and S10 RR 026825) and technical assistance from Ms. Bridget McLaughlin and Mr. Jonathan Van Dyke. Author Contributions Yu Sasaki: performing experiments, analysis of data, preparing

Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte

Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, JapanEriko Tanaka AuthorsSearch for Yu Sasaki in:Nature Research journals • PubMed • Google ScholarSearch for Teruo Hidaka

Impact of preoperative ultrasonography findings on the patency rate of vascular access in Japanese hemodialysis patients

Background Although ultrasonography before a vascular access (VA) operation has become popular in recent years, benchmarks for the diameter or blood flow of arteries or veins are not defined in Japan. The objective of the present study is to analyze the relationship between preoperative US findings and the patency rate of VA in Japanese hemodialysis patients. Methods 139 patients...

Podocin is translocated to cytoplasm in puromycin aminonucleoside nephrosis rats and in poor-prognosis patients with IgA nephropathy

Podocytes serve as the final barrier to urinary protein loss through a highly specialized structure called a slit membrane and maintain foot process and glomerular basement membranes. Podocyte injury results in progressive glomerular damage and accelerates sclerotic changes, although the exact mechanism of podocyte injury is still obscure. We focus on the staining gap (podocin...

Characteristics of Small Bowel Polyps Detected in Cowden Syndrome by Capsule Endoscopy

Cowden syndrome is an uncommon, autosomal dominant disease characterized by multiple hamartomas and hyperplastic lesions in the skin, mucous membrane, brain, breast, thyroid, and gastrointestinal tract. About 30% of Cowden syndrome cases are reportedly complicated by malignant diseases. Hamartomatous polyps occur throughout the gastrointestinal tract, the most common sites being...

Significance of Urinary Full-Length Megalin in Patients with IgA Nephropathy

Background and Objectives Megalin is highly expressed at the apical membranes of proximal tubular epithelial cells. A urinary full-length megalin (C-megalin) assay is linked to the severity of diabetic nephropathy in type 2 diabetes. This study examined the relationship between levels of urinary C-megalin and histological findings in adult patients with IgA nephropathy (IgAN...

Delayed Neurologic Deficit due to Foraminal Stenosis following Osteoporotic Late Collapse of a Lumbar Spine Vertebral Body

, M. Gotoh, and M. Pirpiris Copyright © 2013 Yu Sasaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution

Notch2 activation ameliorates nephrosis

Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, JapanEriko Tanaka, Katsuhiko Asanuma, Eunhee Kim, Yu Sasaki, Juan Alejandro Oliva Trejo ... Asanuma in:Nature Research journals • PubMed • Google ScholarSearch for Eunhee Kim in:Nature Research journals • PubMed • Google ScholarSearch for Yu Sasaki in:Nature Research journals • PubMed • Google