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Is Sleep Quality More Important than Sleep Duration for Public Health?

publication August, 2016 Address correspondence to: Yu Sun Bin, Clinical and Population Perinatal Health Research, Level 2 , Building 52 , Royal North Shore Hospital, Sydney, NSW , Australia; Tel: + 61 2 9462

Genetic variants of PPAR-gamma coactivator 1B augment NLRP3-mediated inflammation in gouty arthritis

Ting-Jui Chen 0 4 7 Yu-Sun Chang 5 7 Der-Yuan Chen 6 7 Shuen-Iu Hung 0 7 0 Institute of Pharmacology, Program in Molecular Medicine, School of Medicine, National Yang-Ming University , Taipei 1

The effects of both single-locus and multi-locus interaction on the clinical manifestations of IgA nephropathy in Southern Han Chinese

Background Immunoglobulin A nephropathy (IgAN) is one of the most common types of glomerulonephritis throughout the world. It is considered to be a complex disease, to which both genetic and environmental factors contribute. Our previous study has shown a potential interaction of C1GALT1−330G/T and IL5RA31 + 197A/G on the susceptibility of IgAN in Southern Han Chinese. However...

Sleeping at the Limits: The Changing Prevalence of Short and Long Sleep Durations in 10 Countries

Yu Sun Bin Nathaniel S. Marshall Nick Glozier nick.glozier@sydney Short (6 hours) and long (>9 hours) sleep durations are risk factors for mortality and morbidity. To investigate whether the ... , University of Sydney, Sydney, Australia (Yu Sun Bin, Nathanial S. Marshall, Nick Glozier); Brain & Mind Research Institute, University of Sydney, Sydney, Australia (Yu Sun Bin, Nick Glozier); Discipline of

Inferring microRNA–mRNA causal regulatory relationships from expression data

Motivation: microRNAs (miRNAs) are known to play an essential role in the post-transcriptional gene regulation in plants and animals. Currently, several computational approaches have been developed with a shared aim to elucidate miRNA–mRNA regulatory relationships. Although these existing computational methods discover the statistical relationships, such as correlations and...

An experimental research into endostatin microbubble combined with focused ultrasound for anti-tumor angiogenesis in colon cancer

Objective: to evaluate the therapeutic effect of targeted endostatin-loaded microbubbles, combined with improved, focused, directional ultrasound radiation for inhibition of subcutaneous translocation in situ colon tumor angiogenesis in colon cancer. Methods: 65 BALB/c nude mice with subcutaneous translocation in situ colon tumors were randomly divided into five groups. Group A...

Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death

Chemopreventive agents generate oxidative stress, which culminates in cell death and may be part of a general mechanism of chemoprevention. The redox-responsive cyclooxygenase (COX)-2, overexpressed during carcinogenesis, has been a target for cancer prevention. To assess the potential link between chemopreventive agents, oxidative stress and COX-2, we studied the chemopreventive...

The discovery of transcriptional modules by a two-stage matrix decomposition approach

Huai Li 0 Yu Sun 0 Ming Zhan 0 0 Bioinformatics Unit, Branch of Research Resources, National Institute on Aging , NIH, Baltimore, MD 21224 , USA Motivation: We address the problem of identifying

Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect

Non-steroidal anti-inflammatory drugs such as sulindac are promising chemoprevention agents against colon cancer, but their weak potency and side effects limit their use for both chemoprevention and chemotherapy. Here, we evaluated the effect of a new sulindac derivative, phospho-sulindac or OXT-922, on the growth of human cancer cell lines and its mechanism of action. OXT-922...

BZS1, a B-box Protein, Promotes Photomorphogenesis Downstream of Both Brassinosteroid and Light Signaling Pathways

Photomorphogenesis is controlled by multiple signaling pathways, including the light and brassinosteroid (BR) pathways. BR signaling activates the BZR1 transcription factor, which is required for suppressing photomorphogenesis in the dark. We identified a suppressor of the BR hypersensitive mutant bzr1–1D and named it bzr1–1D suppressor1-Dominant (bzs1–D). The bzs1–D mutation was...

A gender-specific association of CNV at 6p21.3 with NPC susceptibility†

Copy number variations (CNVs), a major source of human genetic polymorphism, have been suggested to have an important role in genetic susceptibility to common diseases such as cancer, immune diseases and neurological disorders. Nasopharyngeal carcinoma (NPC) is a multifactorial tumor closely associated with genetic background and with a male preponderance over female (3:1...

Ferrophilic Characteristics of Vibrio vulnificus and Potential Usefulness of Iron Chelation Therapy

We determined the ferrophilic characteristics of Vibrio vulnificus to evaluate the potential usefulness of iron chelation therapy for the prevention of V. vulnificus infection. Readily available non–transferrin-bound iron (NTBI) is required for the initiation of V. vulnificus growth under in vitro iron-limited conditions and human ex vivo conditions. NTBI aided efficient...

TUMOR MODELS (IN VIVO/IN VITRO)

Science is based on the experimental method since the time of Galileo and Descartes. Even the most brilliant theories and hypothesis must be experimentally verified. The general theory of relativity gained its magnificence only after the solar eclipse of 1919 confirmed the deflection of light experimentally. From that moment, the theory that the space-time bends became reality...

TUMOUR BIOLOGY

DIG (Desmoplastic Infantile Ganglioglioma) is a rare intracranial neoplasm classified as WHO grade I tumor under neuronal and mixed neuronal glial tumors (under 2007 World Health Organization brain tumor classification). It is usually considered to have a good prognosis but 40% of the cases require additional medical, radiation and/or further surgical intervention and 15% of...

LOW GRADE GLIOMAS

. LG-024. TARGETING BRAF MUTANTS FOR PEDIATRIC LOW-GRADE ASTROCYTOMAS Yu Sun, Sara Buhrlage, Catherine Pilarz, John Alberta, Charles Stiles, and Nathanael Gray; Dana-Farber Cancer Institute, Boston, MA

CELL BIOLOGY AND SIGNALING

Ikaros, a DNA-binding protein also known as Ikaros family zinc finger protein 1 (IKZF1), was initially shown to function critically in hematopoietic differentiation. Deletion or mutation of Ikaros has been associated with lymphoblastic, as well as acute and chronic myelogenous leukemias demonstrating that Ikaros can act as a tumor suppressor. Ikaros is predominantly expressed in...