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CELL BIOLOGY AND SIGNALING

Ikaros, a DNA-binding protein also known as Ikaros family zinc finger protein 1 (IKZF1), was initially shown to function critically in hematopoietic differentiation. Deletion or mutation of Ikaros has been associated with lymphoblastic, as well as acute and chronic myelogenous leukemias demonstrating that Ikaros can act as a tumor suppressor. Ikaros is predominantly expressed in...

LOW GRADE GLIOMAS

. LG-024. TARGETING BRAF MUTANTS FOR PEDIATRIC LOW-GRADE ASTROCYTOMAS Yu Sun, Sara Buhrlage, Catherine Pilarz, John Alberta, Charles Stiles, and Nathanael Gray; Dana-Farber Cancer Institute, Boston, MA

TUMOUR BIOLOGY

DIG (Desmoplastic Infantile Ganglioglioma) is a rare intracranial neoplasm classified as WHO grade I tumor under neuronal and mixed neuronal glial tumors (under 2007 World Health Organization brain tumor classification). It is usually considered to have a good prognosis but 40% of the cases require additional medical, radiation and/or further surgical intervention and 15% of...

TUMOR MODELS (IN VIVO/IN VITRO)

Science is based on the experimental method since the time of Galileo and Descartes. Even the most brilliant theories and hypothesis must be experimentally verified. The general theory of relativity gained its magnificence only after the solar eclipse of 1919 confirmed the deflection of light experimentally. From that moment, the theory that the space-time bends became reality...

Erratum: Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone

-Xiang Su Yu Sun Wen-Sen Liu Zhuang Wang Cheng-Yu Wang Zhao-Yang Bu Zhen-Dong Guo Liu-Bo Zhang Wei-Min Nie Chang-Qing Bai Chun-Hua Sun Xiao-Ping An Pei-Song Xu Xiang-Li-Lan Zhang Yong Huang Zhi-Qiang Mi

Induction of inducible nitric oxide synthase by Epstein-Barr virus B95-8-derived LMP1 in Balb/3T3 cells promotes stress-induced cell death and impairs LMP1-mediated transformation

The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) causes cellular transformation and activation of several intracellular signaling events. In this report, we show that BLMP1 (encoded by the LMP1 gene derived from the B95-8 strain of EBV) triggers the expression of inducible nitric oxide synthase (iNOS) in Balb/3T3 fibroblasts. Intriguingly, NLMP1, a natural...

Functional characterization of Trip10 in cancer cell growth and survival

Background The Cdc42-interacting protein-4, Trip10 (also known as CIP4), is a multi-domain adaptor protein involved in diverse cellular processes, which functions in a tissue-specific and cell lineage-specific manner. We previously found that Trip10 is highly expressed in estrogen receptor-expressing (ER+) breast cancer cells. Estrogen receptor depletion reduced Trip10 expression...

Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone

Laboratory of Pathogen and Biosecurity, Beijing 100071, ChinaYi-Gang Tong, Long Liang, Hong-Guang Ren, Hang Fan, Yuan Jin, Yue Teng, Yi Hu, Yong-Qiang Deng, Yu Sun, Zhuang Wang, Chun-Hua Sun, Xiao-Ping An ... 100071, China.Yi-Gang Tong, Yi Hu, Yong-Qiang Deng, Yu Sun, Zhuang Wang, Chun-Hua Sun & Jia-Fu JiangKey Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130122, China.Jun Qian

Electroporation-mediated and EBV LMP1-regulated gene therapy in a syngenic mouse tumor model

Latent membrane protein 1 (LMP1) is an Epstein–Barr virus (EBV)-encoded oncogene expressed in EBV-associated nasopharyngeal carcinoma (NPC). Previous studies indicate that a strategy combining LMP1-mediated NF-κB activation and the HSV thymidine kinase/Ganciclovir (HSVtk/GCV) prodrug system leads to regression of tumor growth in nude mice. To improve the efficacy of this strategy...

Transcriptome coexpression map of human embryonic stem cells

Background Human embryonic stem (ES) cells hold great promise for medicine and science. The transcriptome of human ES cells has been studied in detail in recent years. However, no systematic analysis has yet addressed whether gene expression in human ES cells may be regulated in chromosomal domains, and no chromosomal domains of coexpression have been identified. Results We...

Evaluation of Human Leukocyte Antigen-A (HLA-A), Other Non-HLA Markers on Chromosome 6p21 and Risk of Nasopharyngeal Carcinoma

Background The association between human leukocyte antigen (HLA) genes (located in the Major Histocompatibility Complex [MHC] region of chromosome 6p21) and NPC has been known for some time. Recently, two genome-wide association studies (GWAS) conducted in Taiwan and China confirmed that the strongest evidence for NPC association was mapped to the MHC region. It is still unclear...

Effects of coffee and caffeine on bladder dysfunction in streptozotocin-induced diabetic rats

Aim:To explore the effects and mechanisms of caffeine and coffee on bladder dysfunction in streptozotocin-induced diabetic rats.Methods:Sprague-Dawley male rats were divided randomly into 4 groups: control, diabetes mellitus (DM), DM with coffee treatment, and DM with caffeine treatment. The diabetic rat was induced by intraperitoneal injection of streptozotocin (60 mg/kg). After...

Secretome-Based Identification of ULBP2 as a Novel Serum Marker for Pancreatic Cancer Detection

Background To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for PC detection because its mRNA level was also found to be significantly...

Genetic Polymorphisms of a Novel Vascular Susceptibility Gene, Ninjurin2 (NINJ2), Are Associated with a Decreased Risk of Alzheimer's Disease

Background Accumulated evidences have shown that vascular risk factors, e.g., hypertension, diabetes mellitus and hyperlipidemia, may be related to the risk of dementia. This study investigated the association between genetic polymorphisms of a vascular susceptibility gene, Ninjurin2 (NINJ2), and the risk of dementia, which has not been explored previously. Methods A total of 275...

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress. We modified the use of antibody arrays to provide a quantitative assessment of factors secreted by senescent cells. We show that human cells induced to senesce by genotoxic stress secrete myriad factors associated with...

Triglyceride Levels Are Closely Associated with Mild Declines in Estimated Glomerular Filtration Rates in Middle-Aged and Elderly Chinese with Normal Serum Lipid Levels

Objective To investigate the relationship between lipid profiles [including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C)] and a mild decline in the estimated glomerular filtration rate (eGFR) in subjects with normal serum lipid levels. Design and Methods In this study, we included 2647...

Ferrophilic Characteristics of Vibrio vulnificus and Potential Usefulness of Iron Chelation Therapy

We determined the ferrophilic characteristics of Vibrio vulnificus to evaluate the potential usefulness of iron chelation therapy for the prevention of V. vulnificus infection. Readily available non–transferrin-bound iron (NTBI) is required for the initiation of V. vulnificus growth under in vitro iron-limited conditions and human ex vivo conditions. NTBI aided efficient...

Molecular cloning, expression and characterization of the zebrafish bram1 gene, a BMP receptor-associated molecule

SummaryWe have identified a cDNA clone encoding BMP receptor-associated molecule 1 (BRAM1) from the zebrafish expressed sequence tag (EST) database. The 2606 bp full-length bram1 cDNA was cloned, and further confirmed by nucleotide sequencing. The zebrafish sequence encodes a protein of 195 amino acids with an evolutionarily conserved MYND domain, which displays ∼ ∼98% homology...

Serum Uric Acid and Non-Alcoholic Fatty Liver Disease in Non-Diabetic Chinese Men

Disease in Non-Diabetic Chinese Men Yuanliang Xie Mengjie Wang Youjie Zhang Shijun Zhang Aihua Tan Yong Gao Zhengjia Liang Deyi Shi Zhang Huang Haiying Zhang Xiaobo Yang Zheng Lu Chunlei Wu Ming Liao Yu ... Sun Xue Qin Yanling Hu Li Li Tao Peng Zhixian Li Xiaoli Yang Zengnan Mo Melania Manco, Scientific Directorate, Bambino Hospital, Italy Increased serum uric acid (SUA) levels may be involved in the

Immobilization of enzyme and antibody on ALD-HfO2-EIS structure by NH3 plasma treatment

Thin hafnium oxide layers deposited by an atomic layer deposition system were investigated as the sensing membrane of the electrolyte-insulator-semiconductor structure. Moreover, a post-remote NH3 plasma treatment was proposed to replace the complicated silanization procedure for enzyme immobilization. Compared to conventional methods using chemical procedures, remote NH3 plasma...