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Predictive Value of Stemness Factor Sox2 in Gastric Cancer Is Associated with Tumor Location and Stage

Cancer stem cells (CSCs) are thought to be the "root" of cancer. Although stemness-related factors ALDH1A1 and Sox2 have been used as markers to identify gastric CSCs, the expression pattern and significance of these factors in gastric cancer have not been sufficiently demonstrated. In this study, the expressions of ALDH1A1 and Sox2 were detected by immunohistochemistry in 122...

Gomisin A is a Novel Isoform-Specific Probe for the Selective Sensing of Human Cytochrome P450 3A4 in Liver Microsomes and Living Cells

Nearly half of prescription medicines are metabolized by human cytochrome P450 (CYP) 3A. CYP3A4 and 3A5 are two major isoforms of human CYP3A and share most of the substrate spectrum. A very limited previous study distinguished the activity of CYP3A4 and CYP3A5, identifying the challenge in predicting CYP3A-mediated drug clearance and drug–drug interaction. In the present study...

Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways

Office of Guizhou Province, China (LH-2014-7566). npg Author contribution Xu-qiang NIE, Ferid MURAD, Yu-qi HE, and Ka BIAN designed the research; Xu-qiang NIE, Huai-hong CHEN, and Jian-yong ZHANG ... conducted experiments; Xu-qiang NIE, Jian-wen YANG, and Hui-jun PAN performed data analysis; Xu-qiang NIE, Wen-xia SONG, Ferid MURAD, Yu-qi HE, and Ka BIAN wrote the manuscript. npg 1 Fu J , Prasad HC

Functional and structural properties of a novel cellulosome-like multienzyme complex: efficient glycoside hydrolysis of water-insoluble 7-xylosyl-10-deacetylpaclitaxel

, Chinese Academy of Sciences, Dalian 116023, ChinaTong-Yi Dou, Hong-Wei Luan, Guang-Bo Ge, Yu-Qi He, Pan Cui, Jia-Yue Wang & Ling YangUniversity of Chinese Academy of Sciences, Beijing 100049, ChinaTong-Yi ... for Han-Fa Zou in:Nature Research journals • PubMed • Google ScholarSearch for Yu-Qi He in:Nature Research journals • PubMed • Google ScholarSearch for Pan Cui in:Nature Research journals • PubMed

Characterization of nuciferine metabolism by P450 enzymes and uridine diphosphate glucuronosyltransferases in liver microsomes from humans and animals

and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme. Cancer Res Author contribution 1994; 54: 4026–35. Yan-liu LU, Yu-qi HE and Guang JI designed the research. 15 Liu HX ... , He YQ, Hu Y, Liu Y, Zhang JW, Li W, et al. Determination of Yan-liu LU and Yu-qi HE performed the main experiments UDP-glucuronosyltransferase UGT2B7 activity in human liver microand wrote the paper