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Search: authors:"Yuexi Gu"

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BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine

Germ-line or somatic inactivation of BRCA1 is a defining feature for a portion of human breast cancers. Here we evaluated the anti-proliferative activity of 198 FDA-approved and experimental drugs against four BRCA1-mutant (HCC1937, MDA-MB-436, SUM1315MO2, and SUM149PT) and four BRCA1-wild-type (MDA-MB-231, SUM229PE, MCF10A, and MCF7) breast cancer cell lines. We found that all...

TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli

, Helsinki, FinlandPauliina M. Munne, Yuexi Gu, Manuela Tumiati, Sonja Koopal, Sanna Uusivirta & Sergey G. KuznetsovBiocenter Oulu and Department of Medical Biochemistry and Molecular Biology, Faculty of ... Sawicki AuthorsSearch for Pauliina M. Munne in:Nature Research journals • PubMed • Google ScholarSearch for Yuexi Gu in:Nature Research journals • PubMed • Google ScholarSearch for Manuela Tumiati in:Nature