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Topological evolution of coexpression networks by new gene integration maintains the hierarchical and modular structures in human ancestors

We analyze the global structure and evolution of human gene coexpression networks driven by new gene integration. When the Pearson correlation coefficient is greater than or equal to 0.5, we find that the coexpression network consists of 334 small components and one “giant” connected subnet comprising of 6317 interacting genes. This network shows the properties of power-law...

BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine

Germ-line or somatic inactivation of BRCA1 is a defining feature for a portion of human breast cancers. Here we evaluated the anti-proliferative activity of 198 FDA-approved and experimental drugs against four BRCA1-mutant (HCC1937, MDA-MB-436, SUM1315MO2, and SUM149PT) and four BRCA1-wild-type (MDA-MB-231, SUM229PE, MCF10A, and MCF7) breast cancer cell lines. We found that all...

TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli

, Helsinki, FinlandPauliina M. Munne, Yuexi Gu, Manuela Tumiati, Sonja Koopal, Sanna Uusivirta & Sergey G. KuznetsovBiocenter Oulu and Department of Medical Biochemistry and Molecular Biology, Faculty of ... Sawicki AuthorsSearch for Pauliina M. Munne in:Nature Research journals • PubMed • Google ScholarSearch for Yuexi Gu in:Nature Research journals • PubMed • Google ScholarSearch for Manuela Tumiati in:Nature