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Combined small RNA and gene expression analysis revealed roles of miRNAs in maize response to rice black-streaked dwarf virus infection

• Google Scholar Search for Yuhan Zhao in:Nature Research journals • PubMed • Google Scholar Search for Zhaodong Meng in:Nature Research journals • PubMed • Google Scholar Search for Meng Zhao in:Nature

Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer

Over 80% of triple negative breast cancers express mutant p53. Mutant p53 often gains oncogenic function suggesting that triple negative breast cancers may be driven by p53 protein type. To determine the chromatin targets of this gain-of-function mutant p53 we used inducible knockdown of endogenous gain-of-function mtp53 in MDA-MB-468 cells in conjunction with stable isotope...

BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

Tumor suppressor p53 is the most frequently mutated gene in tumors. Many mutant p53 (mutp53) proteins promote tumorigenesis through the gain-of-function (GOF) mechanism. Mutp53 proteins often accumulate to high levels in tumors, which is critical for mutp53 GOF. Its underlying mechanism is poorly understood. Here, we found that BAG2, a protein of Bcl-2 associated athanogene (BAG...

Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis

Glutaminase (GLS) isoenzymes GLS1 and GLS2 are key enzymes for glutamine metabolism. Interestingly, GLS1 and GLS2 display contrasting functions in tumorigenesis with elusive mechanism; GLS1 promotes tumorigenesis, whereas GLS2 exhibits a tumor suppressive function. In this study, we found that GLS2 but not GLS1 binds to small GTPase Rac1 and inhibits its interaction with Rac1...

53BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-κB through miR-146a

p53-binding protein-1 (53BP1) plays a critical role in cell cycle checkpoint and DNA repair activities. Recently, 53BP1 was recognized as a potential tumor suppressor gene. In this study, we investigated its tumor suppressor function in breast cancer. In clinical samples, we observed a lower level of 53BP1 expression in the cancer lesions than in the matched non-tumor tissues...

Metadherin Mediates Lipopolysaccharide-Induced Migration and Invasion of Breast Cancer Cells

Background Breast cancer is the most prevalent cancer in women worldwide and metastatic breast cancer has very poor prognosis. Inflammation has been implicated in migration and metastasis of breast cancer, although the exact molecular mechanism remains elusive. Principal Findings We show that the pro-inflammatory endotoxin Lipopolysaccharide (LPS) upregulates the expression of...

LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers

, Xuetian Yue, Yuhan Zhao, Xiaoyan Li, Lihua Wu, Cen Zhang, Zhen Liu, Kevin Lin, Juan Liu, Zhiyuan Shen, Zhaohui Feng & Wenwei HuDepartment of Breast Surgery, Qilu Hospital, Shandong University, Ji'nan 250012 ... -Monette & Ken H. Young AuthorsSearch for Haiyang Yu in:Nature Research journals • PubMed • Google ScholarSearch for Xuetian Yue in:Nature Research journals • PubMed • Google ScholarSearch for Yuhan Zhao