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Synthesis and Cytotoxicity of POSS Modified Single Walled Carbon Nanotubes

© 2015 Yuhua Xue and Hao Chen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium

Synthesis and Cytotoxicity of POSS Modified Single Walled Carbon Nanotubes

© 2015 Yuhua Xue and Hao Chen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium

Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription

The AF4/FMR2 proteins AFF1 and AFF4 act as a scaffold to assemble the Super Elongation Complex (SEC) that strongly activates transcriptional elongation of HIV-1 and cellular genes. Although they can dimerize, it is unclear whether the dimers exist and function within a SEC in vivo. Furthermore, it is unknown whether AFF1 and AFF4 function similarly in mediating SEC-dependent...

PAF-derived nitrogen-doped 3D Carbon Materials for Efficient Energy Conversion and Storage

Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 (USA)Zhonghua Xiang, Dan Wang, Yuhua Xue & Liming DaiState Key Lab of Organic–Inorganic Composites, Beijing University of ... Research journals • PubMed • Google ScholarSearch for Yuhua Xue in:Nature Research journals • PubMed • Google ScholarSearch for Liming Dai in:Nature Research journals • PubMed • Google ScholarSearch for Jian

A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb’s Release from 7SK snRNP

The latent reservoirs of HIV represent a major impediment to eradication of HIV/AIDS. To overcome this problem, agents that can activate latent HIV proviruses have been actively sought after, as they can potentially be used in combination with the highly active antiretroviral therapy (HAART) to eliminate the latent reservoirs. Although several chemical compounds have been shown...

Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

CDK9 is the kinase subunit of positive transcription elongation factor b (P-TEFb) that enables RNA polymerase (Pol) II's transition from promoter-proximal pausing to productive elongation. Although considerable interest exists in CDK9 as a therapeutic target, little progress has been made due to lack of highly selective inhibitors. Here, we describe the development of i-CDK9 as...

A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP

The 7SK snRNP represents a major reservoir of activity where P-TEFb, a general transcription factor key for RNA polymerase II elongation, can be withdrawn to promote gene expression, cell growth and development. Within this complex, 7SK snRNA is a central scaffold that coordinates key protein–protein interactions and maintains P-TEFb in an inactive state. Although the stability...