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Secondary findings in 421 whole exome-sequenced Chinese children

Variants with known or possible pathogenicity located in genes that are unrelated to primary disease conditions are defined as secondary findings. Secondary findings are not the primary targets of whole exome and genome sequencing (WES/WGS) assay but can be of great practical value in early disease prevention and intervention. The driving force for this study was to investigate...

Conversion of human adipose-derived stem cells into functional and expandable endothelial-like cells for cell-based therapies

umbilical vein endothelial cells iPSCs Induced pluripotent stem cells KDR Kinase insert domain receptor PSCs Pluripotent stem cells SB SB431542 Fuyi Cheng, Yujing Zhang, Yuan Wang and Hongxin Deng

Differential Expression of TXNIP Isoforms in the Peripheral Leukocytes of Patients with Acute Myocardial Infarction

2018 Academic Editor: Taina K. Lajunen Copyright © 2018 Yujing Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

Serum EBV EA-IgA and VCA-IgA antibodies can be used for risk group stratification and prognostic prediction in extranodal NK/T cell lymphoma: 24-year experience at a single institution

, People's Republic of China 2 Yujing Zhang 3 Department of Radiation Oncology, Sun Yat-sen University Cancer Center , Guangzhou 510060, Guangdong , People's Republic of China 4 Department of Molecular

Cr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes

Hexavalent Chromium [Cr(VI)], which can be found of various uses in industries such as metallurgy and textile dying, can cause a number of human disease including inflammation and cancer. Unlike previous research that focused on Cr(VI)-induced oxidative damage and apoptosis, this study placed emphasis on premature senescence that can be induced by low-dose and long-term Cr(VI...

Chemically Inhomogeneous RE-Fe-B Permanent Magnets with High Figure of Merit: Solution to Global Rare Earth Criticality

University, Hangzhou 310027, ChinaJiaying Jin, Tianyu Ma, Yujing Zhang, Guohua Bai & Mi Yan AuthorsSearch for Jiaying Jin in:Nature Research journals • PubMed • Google ScholarSearch for Tianyu Ma in:Nature ... Research journals • PubMed • Google ScholarSearch for Yujing Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Guohua Bai in:Nature Research journals • PubMed • Google ScholarSearch for

Multi-susceptibile Single-Phased Ceramics with Both Considerable Magnetic and Dielectric Properties by Selectively Doping

and Engineering, Zhejiang University, Hangzhou 310027, P.R. ChinaChuyang Liu, Yujing Zhang, Jingguo Jia, Qiang Sui, Ning Ma & Piyi Du AuthorsSearch for Chuyang Liu in:Nature Research journals • PubMed ... • Google ScholarSearch for Yujing Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Jingguo Jia in:Nature Research journals • PubMed • Google ScholarSearch for Qiang Sui in:Nature

miR-124-3p functions as a tumor suppressor in breast cancer by targeting CBL

Background The origin and development of breast cancer remain complex and obscure. Recently, microRNA (miRNA) has been identified as an important regulator of the initiation and progression of breast cancer, and some studies have shown the essential role of miR-124-3p as a tumor suppressor in breast tumorigenesis. However, the detailed role of miR-124-3p in breast cancer remains...

Consolidation Radiotherapy in Stage IE- IIE, Non-Bulky Primary Gastric Diffuse Large B-Cell Lymphoma with Post-Chemotherapy Complete Remission

Background To investigate the effects of consolidation radiation in patients with stage IE-IIE, non-bulky primary gastric diffuse large B-cell lymphoma (DLBCL). Methods A cohort consisted of 71 consecutive patients with stage IE-IIE, non-bulky primary gastric DLBCL was retrospectively analyzed. All of them had been in complete remission after receiving at least four cycles of...

Identification and Characterization of 293T Cell-Derived Exosomes by Profiling the Protein, mRNA and MicroRNA Components

Cell-derived exosomes are leading candidates for in vivo drug delivery carriers. In particular, exosomes derived from 293T cells are used most frequently, although exosome dosing has varied greatly among studies. Considering their biological origin, it is crucial to characterize the molecular composition of exosomes if large doses are to be administered in clinical settings. In...

miR-93 functions as an oncomiR for the downregulation of PDCD4 in gastric carcinoma

Programmed cell death 4 (PDCD4), as a tumor suppressor gene, is frequently reduced in a variety of tumors, including gastric cancer. Previous findings have indicated that PDCD4 participates in tumorigenesis through the regulation of apoptosis, but the molecular basis of this process has not been fully elucidated, and no studies have shown the upstream regulation of this gene in...

Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression

the interface between the maternal and fetal environments, facilitates the exchange of gases, nutrients, and waste products between the mother and baby and also acts as a Jing Li and Yujing Zhang have ... , 31200969, 81101330, 31271378, and 81250044), and the Research Fund for the Doctoral Program of Higher Education of China (20120091120044). Jing Li, Yujing Zhang, Dameng Li, Yuchen Liu, Danping Chu, Xiaohong

Rapid generation of functional hepatocyte-like cells from human adipose-derived stem cells

Background Liver disease is a major cause of death worldwide. Orthotropic liver transplantation (OLT) represents the only effective treatment for patients with liver failure, but the increasing demand for organs is unfortunately so great that its application is limited. Hepatocyte transplantation is a promising alternative to OLT for the treatment of some liver-based metabolic...

Rapid generation of functional hepatocyte-like cells from human adipose-derived stem cells

Liver disease is a major cause of death worldwide. Orthotropic liver transplantation (OLT) represents the only effective treatment for patients with liver failure, but the increasing demand for organs is unfortunately so great that its application is limited. Hepatocyte transplantation is a promising alternative to OLT for the treatment of some liver-based metabolic disorders or...

Rapid and high-efficiency generation of mature functional hepatocyte-like cells from adipose-derived stem cells by a three-step protocol

The generation of functional hepatocytes is a major challenge for regenerative medicine and drug discovery. Here we show a method that facilitates generation of induced functional hepatocytes (iHeps) from adipose-derived stem cells (ADSCs) within 9 days. iHeps express hepatocytic gene programs and display functions characteristic of mature hepatocytes, including cytochrome P450...

MicroRNA-495 induces breast cancer cell migration by targeting JAM-A

. COMPLIANCE WITH ETHICS GUIDELINES Minghui Cao, Weiwei Nie, Jing Li, Yujing Zhang, Xin Yan, Xiaoxiang Guan, Xi Chen, Ke Zen, Chen-Yu Zhang, Xiaohong Jiang and Dongxia Hou declare that they have no conflict of

Rhein Protects Pancreatic β-Cells From Dynamin-Related Protein-1–Mediated Mitochondrial Fission and Cell Apoptosis Under Hyperglycemia

Jing Liu Zhaohong Chen Yujing Zhang Mingchao Zhang Xiaodong Zhu Yun Fan Shaolin Shi Ke Zen kzen@nju Zhihong Liu Rhein, an anthraquinone compound isolated from rhubarb, has been shown to improve

miR-16 promotes the apoptosis of human cancer cells by targeting FEAT

cells. This study may provide a potential novel target for future cancer therapy. Authors’ contributions Conception and design: Guangxin Zhou, Xi Chen, Yujing Zhang; Development of methodology: Hongwei ... the manuscript: Guangxin Zhou, Xi Chen, Yujing Zhang; Ke Zen, Chen-Yu Zhang, Wen-xian Guan; Study supervision: Guangxin Zhou, Xi Chen, Yujing Zhang. All authors read and approved the final manuscript

Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

Yuda Chen Zhanzhao Yang Ling Jin Waner Jiang Chenfei Tian Geyu Zhou Ke Zen Junfeng Zhang Yujing Zhang Jing Li Chen-Yu Zhang OPEN Cell-derived exosomes have been demonstrated to be efficient carriers of

Pitfalls in Experimental Designs for Characterizing the Transcriptional, Methylational and Copy Number Changes of Oncogenes and Tumor Suppressor Genes

discussions. This work rests almost entirely on open source software and data. Contributors are gratefully acknowledged. Conceived and designed the experiments: ZG Yuannv Zhang. Analyzed the data: JX Yujing ... Zhang YQ Yuannv Zhang. Contributed reagents/ materials/analysis tools: JX DY LQ WZ CW. Wrote the paper: Yuannv Zhang ZG. 1. Weinberg RA ( 1994 ) Oncogenes and tumor suppressor genes . CA Cancer J Clin 44