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12 papers found.
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Ser96Ala genetic variant of the human histidine-rich calcium-binding protein is a genetic predictor of recurrence after catheter ablation in patients with paroxysmal atrial fibrillation

Ser96Ala in a larger sample of cases and controls. 10 / 12 Author Contributions Conceptualization: Yukiko Nakano, Hidenori Ochi. Investigation: Michitaka Amioka, Yuko Onohara, Akinori Sairaku, Takehito

Maintenance of low inflammation level by the ZFHX3 SNP rs2106261 minor allele contributes to reduced atrial fibrillation recurrence after pulmonary vein isolation

Conceptualization: Shunsuke Tomomori, Yukiko Nakano. Data curation: Shunsuke Tomomori, Yukiko Nakano, Hidenori Ochi, Yuko Onohara. Formal analysis: Shunsuke Tomomori, Yukiko Nakano. Funding acquisition: Shunsuke ... Tomomori, Yukiko Nakano. 8 / 11 Investigation: Shunsuke Tomomori, Yukiko Nakano, Akinori Sairaku, Takehito Tokuyama, Chikaaki Motoda, Hiroya Matsumura, Michitaka Amioka, Naoya Hironobe, Yousaku Ookubo

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

PurposeThe purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction.MethodsThis was a single-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 37 patients with borderline or stage 1 hypertension were randomized...

Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

Background Alcohol consumption and oxidative stress are well-known risk factors for developing atrial fibrillation (AF). Single nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genes encoding enzymes of alcohol and reactive aldehyde metabolism, respectively, are prevalent among East Asians. Here, we examined whether these SNPs...

Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese

Background Alcohol consumption and oxidative stress are well-known risk factors for developing atrial fibrillation (AF). Single nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genes encoding enzymes of alcohol and reactive aldehyde metabolism, respectively, are prevalent among East Asians. Here, we examined whether these SNPs...

Rolling Circle Translation of Circular RNA in Living Human Cells

-8602, JapanNaoko Abe & Hiroshi AbeFaculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, JapanNaoko Abe, Yukiko Nakano, Hideto Maruyama, Satoshi Shuto ... , Akira Matsuda & Hiroshi AbeNano Medical Engineering laboratory, RIKEN, 2-1 Hirosawa, Wako-Shi, Saitama 351-0198, JapanNaoko Abe, Mizuki Nishihara, Yukiko Nakano, Aya Shibata, Hideto Maruyama, Yoshihiro

Fluorosed Mouse Ameloblasts Have Increased SATB1 Retention and Gαq Activity

Dental fluorosis is characterized by subsurface hypomineralization and increased porosity of enamel, associated with a delay in the removal of enamel matrix proteins. To investigate the effects of fluoride on ameloblasts, A/J mice were given 50 ppm sodium fluoride in drinking water for four weeks, resulting serum fluoride levels of 4.5 µM, a four-fold increase over control mice...

ZG16p, an animal homolog of β-prism fold plant lectins, interacts with heparan sulfate proteoglycans in pancreatic zymogen granules

ZG16p is a soluble 16 kDa pancreatic protein having structural similarities with plant β-prism fold lectins such as the banana lectin BanLec and the jackfruit lectin jacalin. ZG16p is postulated to be involved in the formation of zymogen granules by interacting with proteoglycans (PGs) localized in pancreatic exocrine granule membranes, but direct evidence was lacking. We...

Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris

Nakano Keiji Matsuda Tomohiko Kisaka Yasuki Kihara We aimed to evaluate whether there was a difference in the arterial stiffness assessed by the cardio-ankle vascular index (CAVI) between patients with

Impact of aldosterone-producing adenoma on cardiac structures in echocardiography

BackgroundPrimary aldosteronism (PA) is a most common cause of secondary hypertension. In PA, left ventricular hypertrophy (LVH) is more progressive than in any other cause of hypertension. Aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) are major subtypes of PA. However there is little information concerned with differences of cardiac structures...

The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties

Dental caries and pulpitis are the most common bacterial infections in humans. However, the immune responses against bacterial stimulation in dental pulp that is bounded by special hard tissues are poorly understood. We examined the initial immune responses in mouse dental pulp after cusp trimming and acid treatment. Using fluorescence immunohistochemistry, two distinct cell...

A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation

Unexplained cardiac arrest (UCA) with documented ventricular fibrillation (VF) is a major cause of sudden cardiac death. Abnormal sympathetic innervations have been shown to be a trigger of ventricular fibrillation. Further, adequate expression of SEMA3A was reported to be critical for normal patterning of cardiac sympathetic innervation. We investigated the relevance of the...