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Metabopolis: scalable network layout for biological pathway diagrams in urban map style

Biological pathways represent chains of molecular interactions in biological systems that jointly form complex dynamic networks. The network structure changes from the significance of biological experiments and layout algorithms often sacrifice low-level details to maintain high-level information, which complicates the entire image to large biochemical systems such as human...

The interaction of clenbuterol hydrochloride with bovine hemoglobin using spectroscopic techniques and molecular modeling methods

The interaction of clenbuterol hydrochloride (CL) to bovine hemoglobin (BHb) under physiological conditions was investigated by using UV-vis absorption, fluorescence, circular dichroism (CD) and molecular modeling. The fluorescence intensity of BHb decreased regularly with the gradual increasing concentration of CL. It is observed that there was a prominent interaction between CL...

The interaction of clenbuterol hydrochloride with bovine hemoglobin using spectroscopic techniques and molecular modeling methods

The interaction of clenbuterol hydrochloride (CL) to bovine hemoglobin (BHb) under physiological conditions was investigated by using UV-vis absorption, fluorescence, circular dichroism (CD) and molecular modeling. The fluorescence intensity of BHb decreased regularly with the gradual increasing concentration of CL. It is observed that there was a prominent interaction between CL...

The interaction of clenbuterol hydrochloride with bovine hemoglobin using spectroscopic techniques and molecular modeling methods

The interaction of clenbuterol hydrochloride (CL) to bovine hemoglobin (BHb) under physiological conditions was investigated by using UV-vis absorption, fluorescence, circular dichroism (CD) and molecular modeling. The fluorescence intensity of BHb decreased regularly with the gradual increasing concentration of CL. It is observed that there was a prominent interaction between CL...

CEA: Combination-based gene set functional enrichment analysis

, 100049, ChinaDuanchen Sun, Yinliang Liu & Ling-Yun Wu AuthorsSearch for Duanchen Sun in:Nature Research journals • PubMed • Google Scholar Search for Yinliang Liu in:Nature Research journals • PubMed ... • Google Scholar Search for Xiang-Sun Zhang in:Nature Research journals • PubMed • Google Scholar Search for Ling-Yun Wu in:Nature Research journals • PubMed • Google Scholar Contributions L.Y.W. and

Porphyromonas gingivalis-Induced MIF Regulates Intercellular Adhesion Molecule-1 Expression in EA.hy926 Cells and Monocyte-Endothelial Cell Adhesion Through the Receptors CD74 and CXCR4

Abstract Porphyromonas gingivalis (P. gingivalis) is an important pathogen that contributes to periodontal disease and causes infections that promote the progression of atherosclerosis. Our previous studies showed that macrophage migration inhibitory factor (MIF) facilitates monocyte adhesion to endothelial cells by regulating the expression of intercellular adhesion molecule-1...

A Facile Synthesis of Highly Nitrogen-Doped Carbon Dots for Imaging and Detection in Biological Samples

A facile, green, and high-output hydrothermal synthesis was proposed for the fabrication of highly fluorescent nitrogen-doped carbon quantum dots (N-doped CDs). The nitrogen content in N-doped CDs reached 19.2% and demonstrated strong blue fluorescence emission was obtained with fluorescence quantum yield (QY) of up to 32.9%, which exhibit high fluorescence quantum yield, high...

Prolyl isomerase Pin1: a promoter of cancer and a target for therapy

University. No.1, Tiansheng Road, Beibei District, 400715, Chongqing, ChinaYang Chen, Hong-ying Yang, Yu-yun Wu & Ying-bin YangDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical ... Scholar Search for Yu-yun Wu in:Nature Research journals • PubMed • Google Scholar Search for Shi-ming Yang in:Nature Research journals • PubMed • Google Scholar Search for Ying-bin Yang in:Nature

Recombinant milk fat globule-EGF factor-8 reduces apoptosis via integrin β3/FAK/PI3K/AKT signaling pathway in rats after traumatic brain injury

Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing, 210008, Jiangsu Province, PR ChinaYong-Yue Gao, Zong Zhuang, Yue Lu, Ling-Yun Wu, Xiang-Sheng Zhang, Wei Li & Chun-Hua ... journals • PubMed • Google Scholar Search for Yue Lu in:Nature Research journals • PubMed • Google Scholar Search for Ling-Yun Wu in:Nature Research journals • PubMed • Google Scholar Search for Zhen-nan

NetGen: a novel network-based probabilistic generative model for gene set functional enrichment analysis

High-throughput experimental techniques have been dramatically improved and widely applied in the past decades. However, biological interpretation of the high-throughput experimental results, such as differential expression gene sets derived from microarray or RNA-seq experiments, is still a challenging task. Gene Ontology (GO) is commonly used in the functional enrichment...

The Influence of Short-Range Correlation on the Phonon Confinement of a Single ZnO Nanowire

Plenty of researches have been performed to probe the diverse properties of ZnO nanowires, but only a few have focused on the physical properties of a single nanowire since to analyze the optical confinement and their correlation lengths along a single nanowire is difficult. In this study, a single ZnO nanowire was synthesized using a Ti-assisted chemical vapor deposition (CVD...

Association of rs662799 in APOA5 with CAD in Chinese Han population

CAD (Coronary Artery Disease) is a complex disease that influenced by various environmental and genetic factors. Previous studies have found many single nucleotide polymorphisms (SNPs) associated with the risk of CAD occurrence. However, the results are inconsistent. In this study, we aim to investigate genetic etiology in Chinese Han population by analysis of 7 SNPs in lipid...

SHMF: Interest Prediction Model with Social Hub Matrix Factorization

With the development of social networks, microblog has become the major social communication tool. There is a lot of valuable information such as personal preference, public opinion, and marketing in microblog. Consequently, research on user interest prediction in microblog has a positive practical significance. In fact, how to extract information associated with user interest...

SHMF: Interest Prediction Model with Social Hub Matrix Factorization

With the development of social networks, microblog has become the major social communication tool. There is a lot of valuable information such as personal preference, public opinion, and marketing in microblog. Consequently, research on user interest prediction in microblog has a positive practical significance. In fact, how to extract information associated with user interest...

SHMF: Interest Prediction Model with Social Hub Matrix Factorization

With the development of social networks, microblog has become the major social communication tool. There is a lot of valuable information such as personal preference, public opinion, and marketing in microblog. Consequently, research on user interest prediction in microblog has a positive practical significance. In fact, how to extract information associated with user interest...

Trichostatin A reverses the chemoresistance of lung cancer with high IGFBP2 expression through enhancing autophagy

Geriatric Medicine, HuaDong Hospital Affiliated with FuDan University, Shanghai, ChinaDongfang Tang, Yun Wu & Wen GaoDepartment of Thoracic Surgery, Shanghai Chest Hospital Affiliated with Shanghai Jiaotong ... for Yun Wu in:Nature Research journals • PubMed • Google Scholar Search for Yang Yang in:Nature Research journals • PubMed • Google Scholar Search for Yifeng Sun in:Nature Research journals • PubMed

High-throughput sequencing of microbial community diversity in soil, grapes, leaves, grape juice and wine of grapevine from China

. Funding acquisition: Yun Wu. Investigation: Yun Wu, Wan Zou, Wei Wang. Methodology: Yu-jie Wei, Jie Xue. Project administration: Yun Wu, Jie Xue. Resources: Jie Xue. Software: Yin-zhuo Yan. Supervision ... : Yun Wu, Jie Xue. Validation: Ge Tian, Li-ye Wang. Visualization: Wan Zou, Wen-rui Ma. Writing ± original draft: Yu-jie Wei. Writing ± review & editing: Yu-jie Wei. 14 / 17 15 / 17 16 / 17 1

The influence of physical activity, sedentary behavior on health-related quality of life among the general population of children and adolescents: A systematic review

Wu. Data curation: Li Hui Han. Formal analysis: Xiu Yun Wu. Methodology: Xiu Yun Wu. Supervision: Xiu Yun Wu. Writing ± original draft: Xiu Yun Wu. Writing ± review & editing: Xiu Yun Wu, Li Hui ... Table. Literature search strategies for the databases of MEDLINE, EMBASE and PSYCINFO (Table A-Table C). (DOC) 23 / 29 S2 Table. PRISMA checklist. (DOC) Author Contributions Conceptualization: Xiu Yun

Determinants of Thermostability in Serine Hydroxymethyltransferase Identified by Principal Component Analysis

Protein thermostability has received growing attention in recent years. Little is known about the determinants of thermal resistance in individual protein families. However, it is known that the mechanism is family-dependent and not identical for all proteins. We present a multivariate statistical analysis to find the determinants of thermostability in one protein family, the...