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Search: authors:"Yung-Yee Chang"

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High frequency of SPG4 in Taiwanese families with autosomal dominant hereditary spastic paraplegia

Background Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative diseases characterized by progressive spasticity and weakness of the lower limbs. SPG4, SPG3A and SPG31 are the three leading causes of autosomal dominant (AD) HSPs. Methods A total of 20 unrelated AD-HSP families were recruited for clinical and genetic assessment. Detection of mutations in SPG4...