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Search: authors:"Yuri Yamaguchi"

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Utility of Ki67 labeling index, cyclin D1 expression, and ER-activity level in postmenopausal ER-positive and HER2-negative breast cancer with neoadjuvant chemo-endocrine therapy

: Sasagu Kurozumi, Yuri Yamaguchi, Hiroshi Matsumoto, Masafumi Kurosumi, Kenichi Inoue. 10 / 13 Data curation: Sasagu Kurozumi, Hiroshi Matsumoto, Kenichi Inoue. Formal analysis: Sasagu Kurozumi, Yuri ... Yamaguchi, Masafumi Kurosumi. Investigation: Sasagu Kurozumi, Yuri Yamaguchi, Masafumi Kurosumi, Shin-ichi Hayashi, Kenichi Inoue. Methodology: Sasagu Kurozumi, Yuri Yamaguchi, Masafumi Kurosumi, Shin-ichi

Contribution of Estrone Sulfate to Cell Proliferation in Aromatase Inhibitor (AI) -Resistant, Hormone Receptor-Positive Breast Cancer

Aromatase inhibitors (AIs) effectively treat hormone receptor-positive postmenopausal breast cancer, but some patients do not respond to treatment or experience recurrence. Mechanisms of AI resistance include ligand-independent activation of the estrogen receptor (ER) and signaling via other growth factor receptors; however, these do not account for all forms of resistance. Here...

Detection of Estrogen-Independent Growth-Stimulating Activity in Breast Cancer Tissues: Implication for Tumor Aggressiveness

Estrogen and various growth factors affecting tumor behavior are present in the breast cancer microenvironment, but their comprehensive effects and signal crosstalks are different in each case. However, there is no system to evaluate the factors, detected in individual breast cancer cases, that regulate ER activity and tumor progression. In this study, we analyzed the effects of...