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Excitation Mechanism of Surface Plasmon Polaritons for Surface Plasmon Sensor With 1D Metal Grating Structure for High Refractive Index Medium

The excitation mechanism of surface plasmon polaritons (SPPs) in a surface plasmon sensor with a one-dimensional (1D) Au diffraction grating on a glass substrate is studied herein. The sensitivity of the sensor for application to a refractometer is also characterized. The SPPs are excited at the following two types of interface: one between the Au grating and the glass substrate...

Vasodilator-stimulated phosphoprotein (VASP) is not a major mediator of platelet aggregation, thrombogenesis, haemostasis, and antiplatelet effect of prasugrel in rats

Ito Kousaku Ohno Yuka Morikawa Atsuyuki Tomizawa Makoto Mizuno Atsuhiro Sugidachi Published: xx xx xxxx Vasodilator-stimulated phosphoprotein (VASP) is a member of actin regulatory proteins implicated

Correction to: Generation and characterization of tissue-type plasminogen activator transgenic rats

In the original publication of the article, the sentence in “Result” section have been incorrectly published as: “Three lines of tPA Tg rats were generated and analyzed by Southern blotting to confirm the presence of the transgene in genomic DNA. When rat DNA was digested with EcoRI and hybridized to the tPA probe described in “Materials and methods”, a 1.0 kb band was detected...

Generation and characterization of tissue-type plasminogen activator transgenic rats

To address a species difference in the responsiveness to human recombinant tissue-type plasminogen activator (rt-PA) between rats and humans, tPA transgenic (Tg) rats were generated and characterized. In the rats, transcriptional regulation of tPA was designed under the control of the endogenous tPA promoter. There were no significant differences in hematological parameters...

Mechanisms of damage formation in glass in the process of femtosecond laser drilling

The development of femtosecond lasers has renovated micromachining technology, enabling the microdrilling of transparent materials at high speed. Although effective, this technique is still imperfect because irregular microscopic damage occurs during processing. Several factors in the formation of damage induced by a single laser pulse have been suggested; however, the entire...

Number of infection events per cell during HIV-1 cell-free infection

HIV-1 accumulates changes in its genome through both recombination and mutation during the course of infection. For recombination to occur, a single cell must be infected by two HIV strains. These coinfection events were experimentally demonstrated to occur more frequently than would be expected for independent infection events and do not follow a random distribution. Previous...

JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma

Background While treatment failure in cases of head and neck squamous cell carcinoma (HNSCC) frequently takes the form of locoregional recurrences and distant metastasis, our understanding of the mechanisms of metastasis in HNSCC is limited. We initially performed the upstream and key nodes analysis together with whole gene microarray analysis characterized by distant metastatic...

Pretreatment neutrophil-to-lymphocyte ratio predicts the prognosis in patients with metastatic prostate cancer

Background The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response in critical care patients, has been suggested as an independent prognostic factor for several solid malignancies. We investigated the utility of pretreatment NLR as a prognosticator in patients who presented with metastatic prostate cancer. Methods We first investigated the...

Bone management in Japanese patients with prostate cancer: hormonal therapy leads to an increase in the FRAX score

Background Osteoporosis is a common consequence of androgen deprivation therapy (ADT) for prostate cancer. Up to 20 % of men on ADT have suffered from fractures within 5 years. The WHO Fracture Risk Assessment Tool (FRAX) has been utilized to predict the 10-year probability of major osteoporotic and hip fracture. However, to date, no large studies assessing the utility of the...

Neutrophil-to-lymphocyte ratio is a prognostic marker in bladder cancer patients after radical cystectomy

Background There is no reliable biomarker for predicting the prognosis of patients who undergo radical cystectomy for bladder cancer. Recent studies have shown that the neutrophil-to-lymphocyte ratio (NLR) could function as a useful prognostic factor in several types of malignancies. This study aimed to assess the usefulness of NLR in bladder cancer. Methods A total of 74...

Gibberellin deficiency pleiotropically induces culm bending in sorghum: an insight into sorghum semi-dwarf breeding

AffiliationsBioscience and Biotechnology Center, Nagoya University, Furo-cho, Nagoya, Aichi 464-8601, JapanReynante L. Ordonio, Yusuke Ito, Asako Hatakeyama, Kozue Ohmae-Shinohara, Hidemi Kitano, Makoto Matsuoka & Takashi ... Research journals • PubMed • Google ScholarSearch for Yusuke Ito in:Nature Research journals • PubMed • Google ScholarSearch for Asako Hatakeyama in:Nature Research journals • PubMed • Google ScholarSearch

Peroxisome Proliferator–Activated Receptor (PPAR)α Activation Increases Adiponectin Receptors and Reduces Obesity-Related Inflammation in Adipose Tissue: Comparison of Activation of PPARα, PPARγ, and Their Combination

We examined the effects of activation of peroxisome proliferator–activated receptor (PPAR)α, PPARγ, and both of them in combination in obese diabetic KKAy mice and investigated the mechanisms by which they improve insulin sensitivity. PPARα activation by its agonist, Wy-14,643, as well as PPARγ activation by its agonist, rosiglitazone, markedly improved insulin sensitivity...