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Laparoscopic Surgery for Ovarian Cyst Infection with Avoidance of Ureteral Injury and Uterine Perforation following Intrauterine Insemination after Abdominal Modified Radical Trachelectomy

Iijima, Shigenori Hayashi, Yusuke Kobayashi, Kosuke Tsuji, Eiichiro Tominaga, Kouji Banno, and Daisuke Aoki Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582

Laparoscopic Surgery for Ovarian Cyst Infection with Avoidance of Ureteral Injury and Uterine Perforation following Intrauterine Insemination after Abdominal Modified Radical Trachelectomy

Iijima, Shigenori Hayashi, Yusuke Kobayashi, Kosuke Tsuji, Eiichiro Tominaga, Kouji Banno, and Daisuke Aoki Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582

Complexity of the Multi-Service Center Problem

The multi-service center problem is a variant of facility location problems. In the problem, we consider locating p facilities on a graph, each of which provides distinct service required by all vertices. Each vertex incurs the cost determined by the sum of the weighted distances to the p facilities. The aim of the problem is to minimize the maximum cost among all vertices. This...

The Directed Disjoint Shortest Paths Problem

:1603.08073 , 2016 . Richard M. Karp . On the computational complexity of combinatorial problems . Networks , 5 : 45 - 68 , 1975 . Ken-ichi Kawarabayashi , Yusuke Kobayashi, and Bruce Reed . The disjoint paths

C-Terminal Region of Sulfite Reductase Is Important to Localize to Chloroplast Nucleoids in Land Plants

Chloroplast (cp) DNA is compacted into cpDNA-protein complexes, called cp nucleoids. An abundant and extensively studied component of cp nucleoids is the bifunctional protein sulfite reductase (SiR). The preconceived role of SiR as the core cp nucleoid protein, however, is becoming less likely because of the recent findings that SiRs do not associate with cp nucleoids in some...

Development of a Heat-Shock Inducible Gene Expression System in the Red Alga Cyanidioschyzon merolae

The cell of the unicellular red alga Cyanidioschyzon merolae contains a single chloroplast and mitochondrion, the division of which is tightly synchronized by a light/dark cycle. The genome content is extremely simple, with a low level of genetic redundancy, in photosynthetic eukaryotes. In addition, transient transformation and stable transformation by homologous recombination...

Eukaryotic Components Remodeled Chloroplast Nucleoid Organization during the Green Plant Evolution

Chloroplast (cp) DNA is thought to originate from the ancestral endosymbiont genome and is compacted to form nucleoprotein complexes, cp nucleoids. The structure of cp nucleoids is ubiquitously observed in diverse plants from unicellular algae to flowering plants and is believed to be a multifunctional platform for various processes, including cpDNA replication, repair...

Effects of tolvaptan in patients with chronic kidney disease and chronic heart failure

Background Tolvaptan, a vasopressin V2 receptor blocker, has a diuretic effect for patients with heart failure. However, there were a few data concerning the effects of tolvaptan in patients with chronic kidney disease (CKD). Methods We retrospectively analyzed 21 patients with chronic heart failure and CKD. Tolvaptan was co-administered with other diuretics in-use, every day. We...

Characterization of HAF-4- and HAF-9-localizing organelles as distinct organelles in Caenorhabditis elegans intestinal cells

Background The intestinal cells of Caenorhabditis elegans are filled with heterogeneous granular organelles that are associated with specific organ functions. The best studied of these organelles are lipid droplets and acidified gut granules associated with GLO-1, a homolog of the small GTPase Rab38. In this study, we characterized a subset of the intestinal granules in which HAF...

Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer

The goals of drug repositioning are to find a new pharmacological effect of a drug for which human safety and pharmacokinetics are established and to expand the therapeutic range of the drug to another disease. Such drug discovery can be performed at low cost and in the short term based on the results of previous clinical trials. New drugs for gynecologic tumors may be found by...

Edge-disjoint Odd Cycles in 4-edge-connected Graphs

Finding edge-disjoint odd cycles is one of the most important problems in graph theory, graph algorithm and combinatorial optimization. In fact, it is closely related to the well-known max-cut problem. One of the difficulties of this problem is that the Erd�s-P�sa property does not hold for odd cycles in general. Motivated by this fact, we prove that for any positive integer k...

Linear min-max relation between the treewidth of H-minor-free graphs and its largest grid

A key theorem in algorithmic graph-minor theory is a min-max relation between the treewidth of a graph and its largest grid minor. This min-max relation is a keystone of the Graph Minor Theory of Robertson and Seymour, which ultimately proves Wagner's Conjecture about the structure of minor-closed graph properties. In 2008, Demaine and Hajiaghayi proved a remarkable linear min...

Algae Sense Exact Temperatures: Small Heat Shock Proteins Are Expressed at the Survival Threshold Temperature in Cyanidioschyzon merolae and Chlamydomonas reinhardtii

The primitive red alga Cyanidioschyzon merolae inhabits acidic hot springs and shows robust resistance to heat shock treatments up to 63 °C. Microarray analysis was performed to identify the key genes underlying the high temperature tolerance of this organism. Among the upregulated genes that were identified, we focused on two small heat shock proteins (sHSPs) that belong to a...

Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model

Background The metabolic preference of malignant glioma for glycolysis as an energy source is a potential therapeutic target. As a result of the cellular heterogeneity of these tumors, however, the relation between glycolytic preference, tumor formation, and tumor cell clonogenicity has remained unknown. To address this issue, we analyzed the metabolic profiles of isogenic glioma...

Efficacy of cyclosporine combination therapy for new-onset minimal change nephrotic syndrome in adults

Background Cyclosporine and prednisolone combination therapy has been used in the treatment of minimal change nephrotic syndrome (MCNS). However, few studies have evaluated the efficacy of cyclosporine combined with intravenous methylprednisolone pulse therapy (MPT) as a first-line treatment for new-onset MCNS. We conducted a retrospective clinical study to evaluate the efficacy...

Hereditary Endometrial Cancer: Lynch Syndrome

Kouji Banno Iori Kisu Megumi Yanokura Kiyoko Umene Yuya Nogami Kosuke Tsuji Kenta Masuda Arisa Ueki Yusuke Kobayashi Wataru Yamagami Nobuyuki Susumu Daisuke Aoki Lynch syndrome (hereditary

Endometrial Cancer and Hypermethylation: Regulation of DNA and MicroRNA by Epigenetics

Endometrial cancer is the seventh most common cancer in women worldwide. Therefore elucidation of the pathogenesis and development of effective treatment for endometrial cancer are important. However, several aspects of the mechanism of carcinogenesis in the endometrium remain unclear. Associations with genetic variation and mutations of cancer-related genes have been shown, but...

Two RNA editing sites with cis-acting elements of moderate sequence identity are recognized by an identical site-recognition protein in tobacco chloroplasts

The chloroplast genome of higher plants contains 20–40 C-to-U RNA editing sites, whose number and locations are diversified among plant species. Biochemical analyses using in vitro RNA editing systems with chloroplast extracts have suggested that there is one-to-one recognition between proteinous site recognition factors and their respective RNA editing sites, but their rigidness...

Relationship between silent brain infarction and chronic kidney disease

Background. The presence of silent brain infarction (SBI) increases the risk of symptomatic stroke and dementia. The association between SBI and chronic kidney disease (CKD) has not been clarified. Moreover, little is known about what factors are related to SBI in CKD patients and whether the prevalence of SBI differs in CKD stage or cause of CKD. Methods. This is a cross...

Hypertension - experimental models

Introduction and Aims: Whereas ACE2 deletion worsens kidney injury; its amplification ameliorates diabetic nephropathy. We previously showed that circulating ACE2 activity is increased in male diabetic NOD mice. The effect of gonadectomy in diabetic ACE2 knockout (ACE2KO) male mice has not been previously studied. Methods: We study the effect of ACE2 deletion on systolic blood...