Advanced search    

Search: authors:"Yusuke Tanaka"

13 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Structural basis of the correct subunit assembly, aggregation, and intracellular degradation of nylon hydrolase

Nylon hydrolase (NylC) is initially expressed as an inactive precursor (36 kDa). The precursor is cleaved autocatalytically at Asn266/Thr267 to generate an active enzyme composed of an α subunit (27 kDa) and a β subunit (9 kDa). Four αβ heterodimers (molecules A-D) form a doughnut-shaped quaternary structure. In this study, the thermostability of the parental NylC was altered by...

A phase I/II study of GLIF combination chemotherapy for taxane/platinum-refractory/resistant endometrial cancer (GOGO-EM2)

PurposeDevelopment of new treatment strategies for endometrial cancer that has become refractory or resistant to taxane/platinum is a critical need. The present study was a phase I/II study of gemcitabine, levofolinate, irinotecan, and 5-fluorouracil (5-FU) (GLIF) combination chemotherapy to determine optimal dosages, safety, and efficacy.MethodsTaxane/platinum-resistant or...

FGF23 modulates the effects of erythropoietin on gene expression in renal epithelial cells

Shuto Yamamoto,1 Sou Kobayashi,1 Takurou Yano,1 Yusuke Tanaka,1 Kouji Okuda,1 Tomohiro Sonou,1 Tomohiro Shoshihara,1 Yuko Iwashita,1 Yu Iwashita,1 Kouichi Tatsuta,1 Ryo Matoba,2 Shigeo Negi,1 Takashi

Analysis of Heart Transplant Survival Data Using Generalized Additive Models

Copyright © 2013 Masaaki Tsujitani and Yusuke Tanaka. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction

Analysis of Heart Transplant Survival Data Using Generalized Additive Models

Copyright © 2013 Masaaki Tsujitani and Yusuke Tanaka. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction

Four-dimensional variational ocean reanalysis: a 30-year high-resolution dataset in the western North Pacific (FORA-WNP30)

We produced a four-dimensional variational ocean re-analysis for the Western North Pacific over 30 years (FORA-WNP30). It is the first-ever dataset covering the western North Pacific over 3 decades at eddy-resolving resolution. The four-dimensional variational analysis scheme version of the Meteorological Research Institute Multivariate Ocean Variational Estimation system (MOVE...

Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial–mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease of unknown cause. IPF has a distinct histopathological pattern of usual interstitial pneumonia in which fibroblastic foci (FF) represent the leading edge of fibrotic destruction of the lung. Currently there are three major hypotheses for how FF are generated: (1) from resident fibroblasts, (2...

Survival Data Analysis with Time-Dependent Covariates Using Generalized Additive Models

We discuss a flexible method for modeling survival data using penalized smoothing splines when the values of covariates change for the duration of the study. The Cox proportional hazards model has been widely used for the analysis of treatment and prognostic effects with censored survival data. However, a number of theoretical problems with respect to the baseline survival...

A novel device for cleaning the camera port during laparoscopic surgery

of great help, with little expense, for all of laparoscopic surgeons. Disclosures Drs. Eiji Kobayashi, Mamoru Kakuda, Yusuke Tanaka, Akiko Morimoto, Tomomi Egawa-Takata, Shinya Matsuzaki, Toshihiro

Challenges in Diagnosis of Pseudo Vasa Previa

Vasa previa is a rare but clinically important obstetrical complication that can be associated with a low-lying placenta or placenta previa. We aim to convey the challenges in diagnosing this condition by presenting 2 cases of pseudo vasa previa diagnosed antenatally as vasa previa using standard and color Doppler ultrasonography. Both patients were falsely diagnosed; only a low...

Challenges in Diagnosis of Pseudo Vasa Previa

Vasa previa is a rare but clinically important obstetrical complication that can be associated with a low-lying placenta or placenta previa. We aim to convey the challenges in diagnosing this condition by presenting 2 cases of pseudo vasa previa diagnosed antenatally as vasa previa using standard and color Doppler ultrasonography. Both patients were falsely diagnosed; only a low...

Development of an efficient strategy to improve HPV immunization coverage in Japan

Background In Japan, new HPV immunizations have dropped dramatically after repeated adverse media reports and a June 2013 temporary suspension of the government’s recommendation for the vaccine. The aim of the present study was to develop an efficient strategy to improve HPV immunization coverage across Japan. Methods We conducted an internet survey in Japan of mothers of 12–16...

Molecular breeding for transgenic rice with low-phytic-acid phenotype through manipulating myo-inositol 3-phosphate synthase gene

In most plant seeds, phosphorus is stored primarily as myo-inositol 1,2,3,4,5,6-hexakisphosphate (InsP6; phytic acid). Reducing the phytic acid content of seeds is a major breeding target, both to increase the availability of mineral nutrients and to decrease the environmental load of phosphorus. The first step in phytic acid biosynthesis and inositol metabolism is catalyzed by...