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Search: authors:"Yutaka Eguchi"

11 papers found.
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MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells

Regulation of cell death is potentially a powerful treatment modality for intractable diseases such as neurodegenerative diseases. Although there have been many reports about the possible involvement of various types of cell death in neurodegenerative diseases, it is still unclear exactly how neurons die in patients with these diseases, thus treatment strategies based on cell...

Bcl2 Deficiency Activates FoxO through Akt Inactivation and Accelerates Osteoblast Differentiation

Osteoblast apoptosis plays an important role in bone development and maintenance, and is in part responsible for osteoporosis in sex steroid deficiency, glucocorticoid excess, and aging. Although Bcl2 subfamily proteins, including Bcl2 and Bcl-XL, inhibit apoptosis, the physiological significance of Bcl2 in osteoblast differentiation has not been fully elucidated. To investigate...

Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus

• Google ScholarSearch for Yutaka Eguchi in:Nature Research journals • PubMed • Google ScholarSearch for Kazuhiro Oka in:Nature Research journals • PubMed • Google ScholarSearch for Hiroshi Maegawa in:Nature

A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis

Satoshi Gando 0 Daizoh Saitoh Hiroyasu Ishikura Masashi Ueyama Yasuhiro Otomo Shigeto Oda Shigeki Kushimoto Katsuhisa Tanjoh Toshihiko Mayumi Toshiaki Ikeda Toshiaki Iba Yutaka Eguchi Kohji Okamoto

Efficacy of a Novel Class of RNA Interference Therapeutic Agents

RNA interference (RNAi) is being widely used in functional gene research and is an important tool for drug discovery. However, canonical double-stranded short interfering RNAs are unstable and induce undesirable adverse effects, and thus there is no currently RNAi-based therapy in the clinic. We have developed a novel class of RNAi agents, and evaluated their effectiveness in...

Capillary Endothelial Thrombomodulin Expression and Fibrin Deposition in Rats with Continuous and Bolus Lipopolysaccharide Administration

Medical Sciences, Kyoto University, Kyoto, JapanToshinari Toba, Tatsuo Nakamura & Yasuhiko Shimizu AuthorsSearch for Yasuji Terada in:Nature Research journals • PubMed • Google ScholarSearch for Yutaka ... Eguchi in:Nature Research journals • PubMed • Google ScholarSearch for Shuichi Nosaka in:Nature Research journals • PubMed • Google ScholarSearch for Toshinari Toba in:Nature Research journals • PubMed

Expression of HLA-DR and urokinase-type plasminogen activator in stage IV gastric cancer

Background. Some patients with stage IV gastric cancer have a long survival. Host immune response and proteolytic activity in the primary tumor may be associated with outcome in these patients. The purpose of this study was to assess prognostic factors in patients with stage IV far advanced gastric cancer. Methods. Findings in 26 patients who underwent resection of stage IV...

Evidence against a functional site for Bcl-2 downstream of caspase cascade in preventing apoptosis

Apoptotic cell death is driven by ICE family proteases (caspases) and negatively regulated by Bcl-2 family proteins. Although it has been shown that Bcl-2 exerts anti-apoptotic activity by blocking a step(s) leading to the activation of caspases, a role for Bcl-2 and Bcl-xL downstream of the caspase cascade has remained unclear. Here, we show that purified active caspase-3 (CPP32...