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A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis

Satoshi Gando 0 Daizoh Saitoh Hiroyasu Ishikura Masashi Ueyama Yasuhiro Otomo Shigeto Oda Shigeki Kushimoto Katsuhisa Tanjoh Toshihiko Mayumi Toshiaki Ikeda Toshiaki Iba Yutaka Eguchi Kohji Okamoto

A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis

To test the hypothesis that the administration of antithrombin concentrate improves disseminated intravascular coagulation (DIC), resulting in recovery from DIC and better outcomes in patients with sepsis, we conducted a prospective, randomized controlled multicenter trial at 13 critical care centers in tertiary care hospitals. We enrolled 60 DIC patients with sepsis and...