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Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults

Elevated serum or plasma Transforming Growth Factor-β1 (TGF-β1) levels have been linked to cancer and other diseases in numerous studies; however, very few studies have reported an association between circulating TGF-β1 and lifestyle factors in healthy people. We examined the association between serum TGF-β1 levels and gender, age, body mass index (BMI), smoking, and drinking in...

Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults

Elevated serum or plasma Transforming Growth Factor-β1 (TGF-β1) levels have been linked to cancer and other diseases in numerous studies; however, very few studies have reported an association between circulating TGF-β1 and lifestyle factors in healthy people. We examined the association between serum TGF-β1 levels and gender, age, body mass index (BMI), smoking, and drinking in...

Expression of Angiotensin II Receptor-1 in Human Articular Chondrocytes

Background. Besides its involvement in the cardiovascular system, the renin-angiotensin-aldosterone (RAS) system has also been suggested to play an important role in inflammation. To explore the role of this system in cartilage damage in arthritis, we investigated the expression of angiotensin II receptors in chondrocytes. Methods. Articular cartilage was obtained from patients...

Prevalence of non-alcoholic fatty liver disease in children and relationship to metabolic syndrome, insulin resistance, and waist circumference

ObjectivesTo investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) in children and its relationship to metabolic syndrome, insulin resistance, and waist circumference (WC).MethodsThis was a population-based cross-sectional, case–control study. Cases were selected among students of a primary and junior high school, respectively, and age- and sex-matched control...

Effect of anakinra on arthropathy in CINCA/NOMID syndrome

CINCA/NOMID is an autoinflammatory disorder characterized by the triad of neonatal onset of cutaneous symptoms, chronic meningitis, and recurrent fever and it presents with distinctive osteoarthropathy, synovitis mainly of the large joints and overgrowth of epimetaphyseal cartilage, particularly of the long bones. The cartilage overgrowth eventually causes osseous overgrowth and...

Marital status and mortality among Japanese men and women: the Japan Collaborative Cohort Study

Background Several studies have indicated a significant association between marital status and mortality risks. However, most of these studies have compared married and unmarried people without differentiating among single, divorced and widowed status. Moreover, gender differences in mortality rates associated with marital status have not been sufficiently clarified. With...

A scoring system to predict renal outcome in IgA nephropathy: from a nationwide prospective study

Background. Immunoglobulin A (IgA) nephropathy is the most common form of glomerulonephritis in the world, and a substantial number of patients develop end-stage renal disease (ESRD). Although there are several prognostic indicators, it remains difficult to predict the renal outcome in individual patients. Methods. A prospective cohort study was conducted in 97 clinical units in...

ANTIBODY ISOTYPE RESPONSES TO PARAMYOSIN, A VACCINE CANDIDATE FOR SCHISTOSOMIASIS, AND THEIR CORRELATIONS WITH RESISTANCE AND FIBROSIS IN PATIENTS INFECTED WITH SCHISTOSOMA JAPONICUM IN LEYTE, THE PHILIPPINES

We examined whether antibody isotype responses to paramyosin (PM), a vaccine candidate for schistosomiasis, are associated with age-dependent resistance and pathology in liver fibrosis using human sera collected from 139 individuals infected with Schistosoma japonicum in Leyte, The Philippines. We report that IgA and IgG3 responses to PM showed a positive correlation with age and...

A Prospective Cohort Study of Shift Work and Risk of Ischemic Heart Disease in Japanese Male Workers

. Haruo Mikami, Chiba Cancer Center; Dr. Yutaka Inaba, Juntendo University School of Medicine; Dr. Yoshiharu Hoshiyama, University of Human Arts and Sciences; Dr. Hiroshi Suzuki, Niigata University School

Occupational and Environmental Factors and Idiopathic Pulmonary Fibrosis in Japan

YOSHIHIRO MIYAKE 3 SATOSHI SASAKI 1 TETSUJI YOKOYAMA 0 6 7 KINGO CHIDA ARATA AZUMA TAKAFUMI SUDA SHOJI KUDOH NAOMASA SAKAMOTO 5 KAZUSHI OKAMOTO 4 GEN KOBASHI 9 MASAKAZU WASHIO 8 YUTAKA INABA 2 HEIZO

Smoking Cessation and Mortality from Cardiovascular Disease among Japanese Men and Women: The JACC Study

, University of Tsukuba; Dr. Haruo Mikami, Chiba Cancer Center; Dr. Shuji Hashimoto, Fujita Health University School of Medicine; Dr. Yutaka Inaba, Juntendo University School of Medicine; Dr. Yoshiharu Hoshiyama

Relative Motion in Stochastic Velocity and Force Fields

Fundamental Fokker-Planck equations for the probability distribution function P(ξ,t) for the relative distance ξ of two test particles are derived exactly for Gaussian random velocity and force fields. The present formulation clarifies the validity of previous approximate theories on the relative diffusion in random fields. That is, almost all previous results are justified in...

Phase Diagrams of Noise Induced Transitions: Exact Results for a Class of External Coloured Noise

By using the formula for the steady state probability distribution of fluctuation in a nonlinear systems under the influence of two-level Markovian noise, the existence of phase transitions of such a system with the variation of intensity and correlation time of the noise is shown. Explicit results for the Verhulst model and a model for population genetics are given and compared...