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Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells

for each MGMT assay are indicated with an asterisk ? ?; those that were not significantly different are marked ?ns?. (DOCX) Author Contributions Conceptualization: Zachary D. Nagel, Leona D. Samson ... . Funding acquisition: Leona D. Samson. Investigation: Zachary D. Nagel, Andrew A. Beharry, Patrizia Mazzucato, Gaspar J. Kitange. Methodology: Zachary D. Nagel, Andrew A. Beharry, Leona D. Samson

Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response

Common alkylating antitumor drugs, such as temozolomide, trigger their cytotoxicity by methylating the O6-position of guanosine in DNA. However, the therapeutic effect of these drugs is dampened by elevated levels of the DNA repair enzyme, O6-methylguanine DNA methyltransferase (MGMT), which directly reverses this alkylation. As a result, assessing MGMT levels in patient samples...