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72 papers found.
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A high-throughput screen identifies small molecule modulators of alternative splicing by targeting RNA G-quadruplexes

RNA secondary structures have been increasingly recognized to play an important regulatory role in post-transcriptional gene regulation. We recently showed that RNA G-quadruplexes, which serve as cis-elements to recruit splicing factors, play a critical role in regulating alternative splicing during the epithelial-mesenchymal transition. In this study, we performed a high...

Fault Ride Through Strategy for Offshore Wind Farm Integration System via MMC-HVDC

When offshore wind power is transmitted to ac grid through MMC-HVDC, the current and voltage will be quite different from those in traditional ac grid during grid side fault. This paper sets up an offshore wind farm integration system via MMC-HVDC and designs control strategies for each unit in the system. The fault ride through strategy of the system is proposed and its...

Fault Ride Through Strategy for Offshore Wind Farm Integration System via MMC-HVDC

When offshore wind power is transmitted to ac grid through MMC-HVDC, the current and voltage will be quite different from those in traditional ac grid during grid side fault. This paper sets up an offshore wind farm integration system via MMC-HVDC and designs control strategies for each unit in the system. The fault ride through strategy of the system is proposed and its...

A Novel Medical Freehand Sketch 3D Model Retrieval Method by Dimensionality Reduction and Feature Vector Transformation

, China Received 28 December 2015; Revised 14 April 2016; Accepted 26 April 2016 Academic Editor: Syoji Kobashi Copyright © 2016 Zhang Jing and Kang Bao Sheng. This is an open access article distributed

A Novel Medical Freehand Sketch 3D Model Retrieval Method by Dimensionality Reduction and Feature Vector Transformation

, China Received 28 December 2015; Revised 14 April 2016; Accepted 26 April 2016 Academic Editor: Syoji Kobashi Copyright © 2016 Zhang Jing and Kang Bao Sheng. This is an open access article distributed

Real-Time Multifault Rush Repairing Strategy Based on Utility Theory and Multiagent System in Distribution Networks

The problem of multifault rush repair in distribution networks (DNs) is a multiobjective dynamic combinatorial problem with topology constraints. The problem consists of archiving an optimal faults’ allocation strategy to squads and an admissible multifault rush repairing strategy with coordinating switch operations. In this article, the utility theory is introduced to solve the...

Real-Time Multifault Rush Repairing Strategy Based on Utility Theory and Multiagent System in Distribution Networks

The problem of multifault rush repair in distribution networks (DNs) is a multiobjective dynamic combinatorial problem with topology constraints. The problem consists of archiving an optimal faults’ allocation strategy to squads and an admissible multifault rush repairing strategy with coordinating switch operations. In this article, the utility theory is introduced to solve the...

Multiple nucleic acid cleavage modes in divergent type III CRISPR systems

CRISPR-Cas is an RNA-guided adaptive immune system that protects bacteria and archaea from invading nucleic acids. Type III systems (Cmr, Csm) have been shown to cleave RNA targets in vitro and some are capable of transcription-dependent DNA targeting. The crenarchaeon Sulfolobus solfataricus has two divergent subtypes of the type III system (Sso-IIID and a Cmr7-containing...

Outpatient parenteral antibiotic therapy (OPAT) in Asia: missing an opportunity

Objectives: Healthcare facilities internationally have grown outpatient parenteral antibiotic administration services for the last few decades. The literature contains publications from dozens of countries describing systematized processes with specialist oversight and their levels of service provision and outcomes. Such descriptions are absent in the majority of Asian countries...

Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation

The apoptosis of glomerular mesangial cells (GMCs) is considered to be an important contributor to the initiation and development of rat Thy-1 nephritis (Thy-1N) and is accompanied by sublytic C5b-9 deposition. However, the mechanism by which sublytic C5b-9 triggers GMC apoptosis has not been elucidated. In this study, functional and histological examinations were performed on...

LARVA: an integrative framework for large-scale analysis of recurrent variants in noncoding annotations

In cancer research, background models for mutation rates have been extensively calibrated in coding regions, leading to the identification of many driver genes, recurrently mutated more than expected. Noncoding regions are also associated with disease; however, background models for them have not been investigated in as much detail. This is partially due to limited noncoding...

Chronic Co-species Housing Mice and Rats Increased the Competitiveness of Male Mice

Rats are predators of mice in nature. Nevertheless, it is a common practice to house mice and rats in a same room in some laboratories. In this study, we investigated the behavioral and physiological responsively of mice in long-term co-species housing conditions. Twenty-four male mice were randomly assigned to their original raising room (control) or a rat room (co-species...

Simultaneous Determination of 10 Adulterants in Antihypertensive Functional Foods Using Multi-Walled Carbon Nanotubes-Dispersive Solid-Phase Extraction Coupled with High Performance Liquid Chromatography

Consumption of functional foods based on extracts from selected herbs to alleviate hypertension is an increasingly common practice in China. Adulteration of these foods with pharmaceuticals can significantly impact a consumer's health. To control the quality of the functional foods effectively, a method for the simultaneous determination of 10 common adulterants including...

Structural basis for single-stranded RNA recognition and cleavage by C3PO

Translin and translin-associated factor-x are highly conserved in eukaroytes; they can form heteromeric complexes (known as C3POs) and participate in various nucleic acid metabolism pathways. In humans and Drosophila, C3POs cleave the fragmented siRNA passenger strands and facilitate the activation of RNA-induced silencing complex, the effector complex of RNA interference (RNAi...

qDNAmod: a statistical model-based tool to reveal intercellular heterogeneity of DNA modification from SMRT sequencing data

In an isogenic cell population, phenotypic heterogeneity among individual cells is common and critical for survival of the population under different environment conditions. DNA modification is an important epigenetic factor that can regulate phenotypic heterogeneity. The single molecule real-time (SMRT) sequencing technology provides a unique platform for detecting a wide range...

Numerical Investigation on Jet Impingement Behaviors Affected by a Vertically Rotating Disk Suspended Close to the Surface

A simplified physical model is built up to study the swirl flow effect induced by a rotating disk on the jet impingement behaviors, which is adopted to simulate the grinding process. To solve the definition problem of the interface between a rotating disk and a stationary plate in the computational simulation, a tiny gap is set between the rotating disk and the stationary plate...