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Evaluating risk factors of radiation pneumonitis after stereotactic body radiation therapy in lung tumor: Meta-analysis of 9 observational studies

) Acknowledgments Author Contributions Conceptualization: Hongda Lu. Data curation: Zhang Lei. Formal analysis: Hongbin Wu. Writing ? original draft: Chi Lu. Writing ? review & editing: Chi Lu. We thank the

Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer

Hippo pathway is involved in tumorigenesis, and its regulation in cytosol has been extensively studied, but its regulatory mechanisms in the nuclear are not clear. In the current study, using a FBS-inducing model following serum starvation, we identified KDM3A, a demethylase of histone H3K9me1/2, as a positive regulator for hippo target genes. KDM3A promotes gene expression...

Study on Maneuvering Target On-axis Tracking Algorithm of Modified Current Statistical Model

Aiming at the model adaptability and the filter precision on the maneuvering target on-axis tracking, The paper put forward a filter algorithm based on modified current statistical model. The algorithm can enhance the model adaptability to the weak and non-maneuvering maneuvering target. The method uses Unscented Kalman Filter to obtain the importance density function of each...

Spreading inequality: neural computations underlying paying-it-forward reciprocity

People tend to pay the generosity they receive from a person forward to someone else even if they have no chance to reciprocate directly. This phenomenon, known as paying-it-forward (PIF) reciprocity, crucially contributes to the maintenance of a cooperative human society by passing kindness among strangers and has been widely studied in evolutionary biology. To further examine...

Application of intelligent anchor cable axial force monitoring system in foundation pit support engineering

Using the self-developed intelligent anchor (cable) axial force monitoring system, real-time on-line monitoring of the axial force of the prestressed anchor and anchor cable in the foundation pit support structure system is realized. The system has automatic acquisition, wireless transmission, real-time monitoring and other advantages. Through actual engineering application and...

STUDY ON A STEP-ADVANCED FILTER MONITOR FOR CONTINUOUS RADON PROGENY MEASUREMENT

Traditional fixed-filter radon progeny monitors are usually clogged with the loading of dust and cannot be used for radon progeny continuous measurement for long period. To solve this problem, a step-advanced filter (SAF) monitor for radon progeny measurement was developed. This monitor automatically roll and stop the filter at each interview. Radon progeny is collected on a...

Assessing the Associations of Blood Metabolites With Osteoporosis: A Mendelian Randomization Study

Osteoporosis is a metabolic bone disease. The effect of blood metabolites on the development of osteoporosis remains elusive.

The Nutrient and Metabolite Profile of 3 Complementary Legume Foods with Potential to Improve Gut Health in Rural Malawian Children

Background: Environmental enteric dysfunction (EED), frequently seen in rural Malawian children, causes chronic inflammation and increases the risk of stunting. Legumes may be beneficial for improving nutrition and reducing the risk of developing EED in weaning children.

The spray characteristic of gas-liquid coaxial swirl injector by experiment

Using the laser phase Doppler particle analyzer (PDPA), the spray characteristics of gas-liquid coaxial swirl injector were studied. The Sauter mean diameter (SMD), axial velocity and size data rate were measured under different gas injecting pressure drop and liquid injecting pressure drop. Comparing to a single liquid injection, SMD with gas presence is obviously improved. So...

Focus on peritoneal dialysis training: working to decrease peritonitis rates

Patient training has widely been considered to be one of the most critical factors for achieving optimal peritoneal dialysis clinical outcomes, including avoidance of peritonitis. However, research in this important area has been remarkably scant to date. This article will critically review the clinical evidence underpinning PD patient training and will specifically focus on four...

Influenza virus infections in the tropics during the first year of life

Pediatric influenza virus infections in the tropics, particularly during infancy, are not well described. We identified influenza virus infections among infants with non-dengue acute undifferentiated febrile illnesses in San Pablo, Laguna, Philippines, as part of an ongoing clinical study of dengue virus infections during infancy. We found that 31% of infants with non-dengue...

Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy

Autophagy is an evolutionarily conserved cellular process that primarily participates in lysosome-mediated protein degradation. Although autophagy is a cytoplasmic event, how epigenetic pathways are involved in the regulation of autophagy remains incompletely understood. Here, we found that H2B monoubiquitination (H2Bub1) is down-regulated in cells under starvation conditions and...

From the Cover: Autophagy Induction Contributes to Cadmium Toxicity in Mesenchymal Stem Cells via AMPK/FOXO3a/BECN1 Signaling

Mesenchymal stem cells (MSCs) are a valuable in vitro model for investigating the bone toxicity of cadmium (Cd). Autophagy has been proposed to play a pivotal role in Cd-mediated toxicity. The FOXO family proteins are important transcription factors that are essential to autophagy induction. This study investigated the role of autophagy in Cd-induced skeleton damage and its...