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Reduction of die roll height in duplex gears through a sheet-bulk metal forming method

In the existing shearing processes for fabricating parts such as duplex gears, die roll is difficult to avoid. Accordingly, a method based on sheet-bulk metal forming for fabricating a duplex gear with extremely small die roll in one stroke is proposed in the current work. The process could be divided into three stages according to the forming features: upsetting and shearing...

Modeling and experimental investigation of drilling into lunar soils

Dry drilling only with the assistance of an auger is a reliable and realistic approach to remove abundant soils from the side of a bit in the harsh, dry conditions on the Moon. Based on an elementary analysis, using Janssen’s model to reflect the coupling effect among the different components of the stress, the present paper models the conveying dynamics along the helical groove...

Dynamic Output Feedback Control of Discrete Markov Jump Systems based on Event-Triggered Mechanism

Academic Editor: Cui-Qin Ma Copyright © 2018 Zhen Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

†1, 2, Zhen Zhao†1, Abhay P Sagare†1, Yingxi Wu1, Min Wang1, Nelly Chuqui Owens1, Philip B Verghese3, Joachim Herz4, 5, 6, David M Holtzman7 and Berislav V Zlokovic1Email author †Contributed equally ... . Overall, the present data support that the LRP1/apoE pathway in pericytes has a potential to be explored as a therapeutic target for controlling Aβ clearance and levels in AD. Notes Qingyi Ma, Zhen Zhao

Economics, fundamentals, technology, finance, speculation and geopolitics of crude oil prices: an econometric analysis and forecast based on data from 1990 to 2017

It is of real and direct significance for China to cope with oil price fluctuations and ensure oil security. This paper aims to quantitatively analyze the specific contribution ratios of the complex factors influencing international crude oil prices and to establish crude oil price models to forecast long-term international crude oil prices. Six explanatory influential variables...

WOS-ELM-Based Double Redundancy Fault Diagnosis and Reconstruction for Aeroengine Sensor

In order to diagnose sensor fault of aeroengine more quickly and accurately, a double redundancy diagnosis approach based on Weighted Online Sequential Extreme Learning Machine (WOS-ELM) is proposed in this paper. WOS-ELM, which assigns different weights to old and new data, implements weighted dealing with the input data to get more precise training models. The proposed approach...

Improving deep convolutional neural networks with mixed maxout units

open access. The authors would like to thank all of the team members of D605 Laboratory. Author Contributions Conceptualization: Hui-zhen Zhao. Data curation: Hui-zhen Zhao, Fu-xian Liu. Formal ... analysis: Hui-zhen Zhao, Long-yue Li. Funding acquisition: Fu-xian Liu. Investigation: Hui-zhen Zhao. Methodology: Hui-zhen Zhao, Fu-xian Liu. Project administration: Hui-zhen Zhao. Resources: Hui-zhen

Antigen 85B peptidomic analysis allows species-specific mycobacterial identification

Background Nontuberculous mycobacteria (NTM)-mediated infections are a growing cause of worldwide morbidity, but lack of rapid diagnostics for specific NTM species can delay the initiation of appropriate treatment regimens. We thus examined whether mass spectrometry analysis of an abundantly secreted mycobacterial antigen could identify specific NTM species. Methods We analyzed...

Polyacrylamide-Phytic Acid-Polydopamine Conducting Porous Hydrogel for Efficient Removal of Water-Soluble Dyes

of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. ChinaLeijiao Li AuthorsSearch for Zhen Zhao in:Nature Research

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling

Pericytes regulate key neurovascular functions of the brain. Studies in pericyte-deficient transgenic mice with aberrant signaling between endothelial-derived platelet-derived growth factor BB (PDGF-BB) and platelet-derived growth factor receptor β (PDGFRβ) in pericytes have contributed to better understanding of the role of pericytes in the brain. Here, we studied PdgfrβF7/F7...

Burden of tuberculosis in Xinjiang between 2011 and 2015: A surveillance data-based study

manuscript. Author Contributions Conceptualization: Jinbao Liu, Weiming Tang. Data curation: Xiangyan He, Mingqin Cao, Zhen Zhao, Weiming Tang. Formal analysis: Xiangyan He, Mingqin Cao. Methodology ... : Xiangpin Du. Resources: Qifeng Li. Software: Zhen Zhao. Supervision: Jinbao Liu. Validation: Qifeng Li, Jinbao Liu. Writing ± original draft: Xiangyan He, Weiming Tang. Writing ± review & editing

Nicotinamide Administration Improves Remyelination after Stroke

of interest to declare. Authors? Contributions Congxiao Wang conducted all the experiments, integrated the data, edited the figures, and wrote the manuscript. Yi Zhang, Jie Ding, Zhen Zhao, Cheng

Nicotinamide Administration Improves Remyelination after Stroke

, edited the figures, and wrote the manuscript. Yi Zhang, Jie Ding, Zhen Zhao, Cheng Qian, and Ying Luan provided essential assistance. Gao-Jun Teng directed this study, designed the research, and gave key

Control of Cross Talk between Angiogenesis and Inflammation by Mesenchymal Stem Cells for the Treatment of Ocular Surface Diseases

, The College of Optometry, Tianjin 300384, China Received 11 November 2015; Accepted 29 February 2016 Academic Editor: Yingmei Feng Copyright © 2016 Fei Li and Shao-zhen Zhao. This is an open access

The pharmacokinetics and pharmacodynamics of alogliptin in children, adolescents, and adults with type 2 diabetes mellitus

simulations. Jie Liu contributed to data analysis and CSR development and review. Zhen Zhao and Jinhui Xie provided statistical support. Eric Schmidt provided support for PK/PD bioanalytical assays, reviewed ... . Compliance with ethical standards Disclosure of conflicts of interest Caroline Dudkowski, Zhen Zhao, Eric Schmidt, and Jinhui Xie are current employees at Takeda. Jie Liu is a current employee at Merck & Co

Lack of Effect of Vortioxetine on the Pharmacokinetics and Pharmacodynamics of Ethanol, Diazepam, and Lithium

by the Takeda Pharmaceutical Company Ltd and H. Lundbeck A/S. Conflicts of interest Grace Chen, George G. Nomikos, John Affinito, and Zhen Zhao are employees of Takeda Development Center Americas, Inc

Multi-actuated mechanism design considering structure flexibility using correlated performance reinforcing

Multi-actuated rigid-flexible dynamic system exists widely in precision machinery and electrical control fields. The performances, such as kinematic, dynamic, electrical, magnetic, and thermal performances, are correlated and difficult to trap precisely. Therefore, a multi-actuated mechanism design method considering structure flexibility using correlated performance reinforcing...

Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction

To explore the effect of T2DM on cerebral perfusion, and the relationship between cerebral perfusion changes and cognitive impairment as well as diabetic variables, by using a whole-brain arterial spin-labeling (ASL) MRI technique. This prospective study was approved by the local institutional review board and was performed between November 2012 and October 2013. All subjects...