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Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) patients with sensitive epidermal growth factor receptor (EGFR) mutations are successfully treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs); however, resistance to treatment inevitably occurs. Given lipid metabolic reprogramming is widely known as a hallmark of cancer and intimately linked with EGFR-stimulated cancer growth. Activation...

Risk Factors for Sepsis Based on Sepsis-3 Criteria after Orthotopic Liver Transplantation

interest in this work. Authors’ Contributions Yanling Wang and Yu Gu contributed equally to this study. Conceived and designed the experiments: Fei Huang, Dezhao Liu, and Zheng Zhang. Performed the ... experiments: Yanling Wang, Yu Gu, Fei Huang, Dezhao Liu, Zheng Zhang, Niman Zhou, Jiani Liang, and Changyin Lu. Analyzed the data: Yanling Wang and Yu Gu. Wrote the paper: Yanling Wang. Guided the study and

Risk stratification based on components of the complete blood count in patients with acute coronary syndrome: A classification and regression tree analysis

Bai, Yu Peng & Zheng Zhang AuthorsSearch for Xiaowei Niu in:Nature Research journals • PubMed • Google Scholar Search for Guoyong Liu in:Nature Research journals • PubMed • Google Scholar Search for ... • Google Scholar Search for Yu Peng in:Nature Research journals • PubMed • Google Scholar Search for Zheng Zhang in:Nature Research journals • PubMed • Google Scholar Contributions X.N., G.L., and Z.Z

Effects of transcriptional mode on promoter substitution and tandem engineering for the production of epothilones in Myxococcus xanthus

Promoter optimization is an economical and effective approach to overexpress heterologous genes and improve the biosynthesis of valuable products. In this study, we swapped the original promoter of the epothilone biosynthetic gene cluster in Myxococcus xanthus with two endogenous strong promoters P pilA and P groEL1 , respectively, which, however, decreased the epothilone...

Biocompatible 5-Aminolevulinic Acid/Au Nanoparticle-Loaded Ethosomal Vesicles for In Vitro Transdermal Synergistic Photodynamic/Photothermal Therapy of Hypertrophic Scars

Biocompatible 5-aminolevulinic acid/Au nanoparticle-loaded ethosomal vesicle (A/A-ES) is prepared via ultrasonication for synergistic transdermal photodynamic/photothermal therapy (PDT/PTT) of hypertrophic scar (HS). Utilizing ultrasonication, Au nanoparticles (AuNPs) are synthesized and simultaneously loaded in ethosomal vesicles (ES) without any toxic agents, and 5...

Aberrant Expression of miR-362 Promotes Lung Cancer Metastasis through Downregulation of Sema3A

’ Contributions Dan Luo, Zheng Zhang, and Zhi-Nan Chen conceived and designed the experiments. Dan Luo and Zhao Zhang performed the experiments. Dan Luo and Jian Cui analyzed the data. Jia-Yue Li, Lin Yuan, and ... . Wen-Pu Shi and Xi-Wen Dong revised the manuscript. Dan Luo, Zheng Zhang, and Zhao Zhang contributed equally to this work. Funding This study was supported by the Natural Science Foundation of China

Genetic dissection of main and epistatic effects of QTL based on augmented triple test cross design

. Formal analysis: Xueli Zhang, Congwei Sun, Xiong Yuan. Investigation: Xueli Zhang, Congwei Sun, Zheng Zhang, Zhijun Dai, Yuan Chen, Xiong Yuan. Methodology: Congwei Sun, Zheng Zhang, Zhijun Dai, Yuan

Paneth cells: the hub for sensing and regulating intestinal flora

The complex interplay between symbiotic bacteria and host immunity plays a key role in shaping intestinal homeostasis and maintaining host health. Paneth cells, as one of the major producers of antimicrobial peptides in the intestine under steady-state conditions, play a vital role in regulating intestinal flora. Many studies on inflammatory bowel disease (IBD)-associated genes...

Simulating Study on Drive System Performance for Hybrid Electric Bus Based on ADVISOR

Hybrid electric bus has a number of advantages when compared with ordinary passenger cars, but in the dynamic matching and the vehicle performance are difficult to detect, thus limits its development process. In this paper, combined with the actual models, the hybrid electric bus module parameters were modified in the software of ADVISOR (Advanced Vehicle Simulator), main...

A novel injectable calcium phosphate-based nanocomposite for the augmentation of cannulated pedicle-screw fixation

A novel injectable calcium phosphate-based nanocomposite for the augmentation of cannulated pedicle-screw fixation Haolin Sun,1,* Chun Liu,2,* Huiling Liu,2,* Yanjie Bai,3 Zheng Zhang,1 Xuwen Li,1

Quantitative proteomics in A30P*A53T α-synuclein transgenic mice reveals upregulation of Sel1l

He, Zheng Zhang, Zexi Lv, Hongwei Cai, Bo Tian. Validation: Fengjuan Jiao, Zheng Zhang, Zexi Lv. Visualization: Qingzhi Wang. Writing ± original draft: Jianguo Yan. Writing ± review & editing: Bo

Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice

Magnesium (Mg2+) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel involved in cellular and systemic Mg2+ homeostasis. Abnormal expression of TRPM7 is found in numerous cancers, including colon, implicating TRPM7 in this process. To establish...

The effects of kisspeptin-10 on serum metabolism and myocardium in rats

Kisspeptin is a peptide encoded by the Kiss 1 gene and is also called metastin. Previous studies have generally focused on several functions of this peptide, including metastasis, puberty, vasoconstriction and reproduction. However, few studies have focused on the cardiac functions of kisspeptin. In the present study, cardiac histomorphology was observed via TEM (transmission...

Outdoor Air Quality Level Inference via Surveillance Cameras

© 2016 Zheng Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided

Ectodomain Architecture Affects Sequence and Functional Evolution of Vertebrate Toll-like Receptors

. 2014CB542400) and National Natural Science Foundation of China (No. 81570454). Author information Author notesJinlan Wang & Zheng Zhang These authors contributed equally to this work. AffiliationsInstitute ... , Johnson City, TN 37614, USADeling Yin AuthorsSearch for Jinlan Wang in:Nature Research journals • PubMed • Google ScholarSearch for Zheng Zhang in:Nature Research journals • PubMed • Google ScholarSearch

Cyclooxygenase-2 expression is positively associated with lymph node metastasis in nasopharyngeal carcinoma

Background Accumulating evidence has demonstrated that cyclooxygenase-2 (COX-2) is involved in head and neck cancers, especially in nasopharyngeal carcinoma (NPC). However, the association between COX-2 expression and lymph node metastasis in NPC remains uncertain. This systematic review and meta-analysis meta-analysis investigated the relationship between COX-2 expression and...

In Vitro Anti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

Trans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), and sebacic acid (SEA) are the three major fatty acids in royal jelly (RJ). Previous studies have revealed several pharmacological activities of 10-H2DA and 10-HDAA, although the anti-inflammatory effects and underlying mechanisms by which SEA acts are poorly understood. In the present study, we...