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Triclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells

Wenpeng Zhang 1 Zhenqing Zhang 1 0 Department of Pharmacy, The 309th hospital of P la , Beijing, china 1 s tate Key l aboratory of Toxicology and Medical countermeasures, Beijing institute of Pharmacology

Reza Hasmath and Jennifer Y.J. Hsu, eds. NGO Governance and Management in China

. reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Zhenqing Zhang is an

Microbial communities in peatlands along a chronosequence on the Sanjiang Plain, China

sampling sites on the Sanjiang Plain. The map (including the inset map of china) was generated by Zhenqing Zhang using ArcGIS 10.0 ( Full size image ... Agroecology (2016ZKHT-05). Author information Author notes Xue Zhou and Zhenqing Zhang contributed equally to this work. AffiliationsKey Laboratory of Mollisols Agroecology, Northeast Institute of Geography

Fungal communities in ancient peatlands developed from different periods in the Sanjiang Plain, China

Contributions Conceptualization: Chunjie Tian. Data curation: Xue Zhou. Formal analysis: Lei Tian, Jianfeng Zhang. Funding acquisition: Chunjie Tian. Investigation: Zhenqing Zhang, Lina Ma. Methodology ... : Zhenqing Zhang, Shasha Luo. Software: Lei Tian. Supervision: Chunjie Tian. Writing ± original draft: Xue Zhou. Writing ± review & editing: Xue Zhou, Xiujun Li. 13 / 16 14 / 16 15 / 16 1. Yu Z , Beilman

Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection

Countermeasures, Beijing Institute of Pharmacology & Toxicology, 27 Tai-Ping Road, Beijing, 100850, ChinaChao Wang, Xue Li, Xifeng Jiang, Xiaoyu Xu, Wenqing Lai, Tianhong Zhang, Zhenqing Zhang & Keliang LiuKey ... • Google ScholarSearch for Wenqing Lai in:Nature Research journals • PubMed • Google ScholarSearch for Tianhong Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Zhenqing Zhang in:Nature

In Vitro Metabolic Stability of Exendin-4: Pharmacokinetics and Identification of Cleavage Products

The aim of this study was to investigate the metabolic stability and cleavage sites of exendin-4 in rat tissue homogenates, as well as to identify the types of proteases involved in exendin-4 degradation. The stability of exendin-4 in kidney and liver homogenates from rats was evaluated using liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) with...

Tandem MS can distinguish hyaluronic acid from N-acetylheparosan

Isobaric oligosaccharides enzymatically prepared from hyaluronic acid (HA) and N-acetylheparosan (NAH), were distinguished using tandem mass spectrometry. The only difference between the two series of oligosaccharides was the linkage pattern (in HA 1→3 and in NAH 1→4) between glucuronic acid and N-acetylglucosamine residues. Tandem mass spectrometry afforded spectra in which...

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

-Ping Road, Beijing, 100850, ChinaChao Wang, Tianhong Zhang, Zhenqing Zhang & Keliang LiuShanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 201508 ... • PubMed • Google ScholarSearch for Zhenqing Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Xiaoyan Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Jianqing Xu

Heparinase 1 selectivity for the 3,6-di-O-sulfo-2-deoxy-2-sulfamido-α-D-glucopyranose (1,4) 2-O-sulfo-α-L-idopyranosyluronic acid (GlcNS3S6S-IdoA2S) linkages

Porcine intestinal mucosa heparin was partially depolymerized by recombinant heparinase 1 (heparin lyase 1, originating from Flavobacterium heparinum and expressed in Escherichia coli) and then fractionated, leading to the isolation of 22 homogeneous oligosaccharides with sizes ranging from disaccharide to hexadecasaccharide. The purity of these oligosaccharides was determined by...

Chloroquine reduces arylsulphatase B activity and increases chondroitin-4-sulphate: implications for mechanisms of action and resistance

Background The receptors for adhesion of Plasmodium falciparum-infected red blood cells (RBC) in the placenta have been identified as chondroitin-4-sulphate (C4S) proteoglycans, and the more sulphate-rich chondroitin oligosaccharides have been reported to inhibit adhesion. Since the anti-malarial drug chloroquine accumulates in lysosomes and alters normal lysosomal processes, the...

Erratum to: Sequence analysis of alginate-derived oligosaccharides by negative-ion electrospray tandem mass spectrometry

J Am Soc Mass Spectrom MMM In the article, Sequence Analysis of Alginate-Derived Oligosaccharides by Negative-Ion Electrospray Tandem Mass Spectrometry, by Zhenqing Zhang, Guangli Yu, Xia Zhao

Sequence analysis of alginate-derived oligosaccharides by negative-ion electrospray tandem mass spectrometry

Negative-ion electrospray tandem mass spectrometry (ES-MS/MS) with collision-induced dissociation (CID) is attempted for sequence determination of alginate oligosaccharides, derived from polyanionic alginic acid, polymannuronate, and polyguluronate by partial depolymerization using either alginate lyase or mild acid hydrolysis. Sixteen homo- and hetero-oligomeric fragments were...

Multiple and multivalent interactions of novel anti-AIDS drug candidates, sulfated polymannuronate (SPMG)-derived oligosaccharides, with gp120 and their anti-HIV activities

Sulfated polymannuronate (SPMG), a novel anti-AIDS drug candidate, combats HIV-1 infection mainly by binding to gp120 protein with high affinity. To explore the structural basis of this anti-HIV-1 action, size-defined oligosaccharides were prepared by semi-synthesis or separated from native SPMG. In this study, a series of homogeneously sized SPMG fragments are evaluated for...